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    Diabetes Type 2

    Agrawal, R., Zhuang, Y., Cummings, B. P., Stanhope, K. L., Graham, J. L., Havel, P. J., & Gomez-Pinilla, F. (2014)., Deterioration of plasticity and metabolic homeostasis in the brain of the UCD-T2DM rat model of naturally occurring type-2 diabetes., Biochimica Et Biophysica Acta, 1842(9), 1313-1323. doi:10.1016/j.bbadis.2014.05.007 [doi]

    General Studies

    Baranowski, M., Enns, J., Blewett, H., Yakandawala, U., Zahradka, P., & Taylor, C. G. (2012)., Dietary flaxseed oil reduces adipocyte size, adipose monocyte chemoattractant protein-1 levels and T-cell infiltration in obese, insulin-resistant rats., Cytokine, 59(2), 382-391. doi:10.1016/j.cyto.2012.04.004 [doi]
    Bhutta, H. Y., Rajpal, N., White, W., Freudenberg, J. M., Liu, Y., Way, J., . . . Chen, L. (2015)., Effect of roux-en-Y gastric bypass surgery on bile acid metabolism in normal and obese diabetic rats., PloS One, 10(3), e0122273. doi:10.1371/journal.pone.0122273 [doi]
    Blackler, R., Syer, S., Bolla, M., Ongini, E., & Wallace, J. L. (2012)., Gastrointestinal-sparing effects of novel NSAIDs in rats with compromised mucosal defence., PloS One, 7(4), e35196. doi:10.1371/journal.pone.0035196 [doi]
    Blanc, V., & Davidson, N. O. (2011)., Mouse and other rodent models of C to U RNA editing., Methods in Molecular Biology (Clifton, N.J.), 718, 121-135. doi:10.1007/978-1-61779-018-8_7 [doi]
    Boomhower, S. R., Rasmussen, E. B., & Doherty, T. S. (2013), Impulsive-choice patterns for food in genetically lean and obese zucker rats., Behavioural Brain Research, 241, 214-221. doi:10.1016/j.bbr.2012.12.013 [doi]
    Bruijnzeel, A. W., Corrie, L. W., Rogers, J. A., & Yamada, H. (2011)., Effects of insulin and leptin in the ventral tegmental area and arcuate hypothalamic nucleus on food intake and brain reward function in female rats., Behavioural Brain Research, 219(2), 254-264. doi:10.1016/j.bbr.2011.01.020 [doi]
    Buckley, J. L., & Rasmussen, E. B. (2012)., Obese and lean zucker rats demonstrate differential sensitivity to rates of food reinforcement in a choice procedure., Physiology & Behavior, 108, 19-27. doi:10.1016/j.physbeh.2012.10.001 [doi]
    Buckley, J. L., & Rasmussen, E. B. (2014)., Rimonabant's reductive effects on high densities of food reinforcement, but not palatability, in lean and obese zucker rats., Psychopharmacology, 231(10), 2159-2170. doi:10.1007/s00213-013-3366-4 [doi]
    Butcher, J. T., Goodwill, A. G., Stanley, S. C., & Frisbee, J. C. (2013)., Blunted temporal activity of microvascular perfusion heterogeneity in metabolic syndrome: A new attractor for peripheral vascular disease?, American Journal of Physiology.Heart and Circulatory Physiology, 304(4), H547-58. doi:10.1152/ajpheart.00805.2012 [doi]
    Butcher, J. T., Goodwill, A. G., Stanley, S. C., & Frisbee, J. C. (2013)., Differential impact of dilator stimuli on increased myogenic activation of cerebral and skeletal muscle resistance arterioles in obese zucker rats., Microcirculation (New York, N.Y.: 1994), 20(7), 579-589. doi:10.1111/micc.12056 [doi]
    Carrier, B., Wen, S., Zigouras, S., Browne, R. W., Li, Z., Patel, M. S., . . . Rideout, T. C. (2014)., Alpha-lipoic acid reduces LDL-particle number and PCSK9 concentrations in high-fat fed obese zucker rats., PloS One, 9(3), e90863. doi:10.1371/journal.pone.0090863 [doi]
    Casey, J. M., Banz, W. J., Krul, E. S., Butteiger, D. N., Goldstein, D. A., & Davis, J. E. (2013)., Effect of stearidonic acid-enriched soybean oil on fatty acid profile and metabolic parameters in lean and obese zucker rats., Lipids in Health and Disease, 12, 147-511X-12-147. doi:10.1186/1476-511X-12-147 [doi]
    Chantler, P. D., Shrader, C. D., Tabone, L. E., d'Audiffret, A. C., Huseynova, K., Brooks, S. D., . . . Frisbee, J. C. (2015)., Cerebral cortical microvascular rarefaction in metabolic syndrome is dependent on insulin resistance and loss of nitric oxide bioavailability., Microcirculation (New York, N.Y.: 1994), 22(6), 435-445. doi:10.1111/micc.12209 [doi]
    Chen, W., Howell, M. L., Li, Y., Li, R., & Chen, G. (2014), Vitamin A and feeding statuses modulate the insulin-regulated gene expression in zucker lean and fatty primary rat hepatocytes., PloS One, 9(8), e100868. doi:10.1371/journal.pone.0100868 [doi]
    Ciriello, J., & Moreau, J. M. (2012)., Leptin signaling in the nucleus of the solitary tract alters the cardiovascular responses to activation of the chemoreceptor reflex., American Journal of Physiology.Regulatory, Integrative and Comparative Physiology, 303(7), R727-36. doi:10.1152/ajpregu.00068.2012 [doi]
    Clemmer, J. S., Xiang, L., Lu, S., Mittwede, P. N., & Hester, R. L. (2014)., beta2-adrenergic regulation of stress hyperglycemia following hemorrhage in the obese zucker rat., Physiological Reports, 2(12), 10.14814/phy2.12215. Print 2014 Dec 1. doi:10.14814/phy2.12215 [doi]
    Davidson, E. P., Coppey, L. J., Holmes, A., Lupachyk, S., Dake, B. L., Oltman, C. L., . . . Yorek, M. A. (2014)., Characterization of diabetic neuropathy in the zucker diabetic sprague-dawley rat: A new animal model for type 2 diabetes., Journal of Diabetes Research, 2014, 714273. doi:10.1155/2014/714273 [doi]
    Davis, D. D., Ruiz, A. L., Yanes, L. L., Iliescu, R., Yuan, K., Moulana, M., . . . Reckelhoff, J. F. (2012)., Testosterone supplementation in male obese zucker rats reduces body weight and improves insulin sensitivity but increases blood pressure., Hypertension, 59(3), 726-731. doi:10.1161/HYPERTENSIONAHA.111.180943 [doi]
    DeClercq, V., Taylor, C. G., Wigle, J., Wright, B., Tworek, L., & Zahradka, P. (2012)., Conjugated linoleic acid improves blood pressure by increasing adiponectin and endothelial nitric oxide synthase activity., The Journal of Nutritional Biochemistry, 23(5), 487-493. doi:10.1016/j.jnutbio.2011.02.003 [doi]
    Diaz-Villasenor, A., Granados, O., Gonzalez-Palacios, B., Tovar-Palacio, C., Torre-Villalvazo, I., Olivares-Garcia, V., . . . Tovar, A. R. (2013)., Differential modulation of the functionality of white adipose tissue of obese zucker (fa/fa) rats by the type of protein and the amount and type of fat., The Journal of Nutritional Biochemistry, 24(11), 1798-1809. doi:10.1016/j.jnutbio.2013.03.007 [doi]
    Disanzo, B. L., & You, T. (2014)., Effects of exercise training on indicators of adipose tissue angiogenesis and hypoxia in obese rats., Metabolism: Clinical and Experimental, 63(4), 452-455. doi:10.1016/j.metabol.2013.12.004 [doi]
    do Carmo, J. M., da Silva, A. A., Rushing, J. S., & Hall, J. E. (2012)., Activation of the central melanocortin system contributes to the increased arterial pressure in obese zucker rats., American Journal of Physiology.Regulatory, Integrative and Comparative Physiology, 302(5), R561-7. doi:10.1152/ajpregu.00392.2011 [doi]
    Feresin, R. G., Johnson, S. A., Elam, M. L., Jo, E., Arjmandi, B. H., & Hakkak, R. (2014)., Effects of obesity on bone mass and quality in ovariectomized female zucker rats., Journal of Obesity, 2014, 690123. doi:10.1155/2014/690123 [doi]
    Fink, A. M., Topchiy, I., Ragozzino, M., Amodeo, D. A., Waxman, J. A., Radulovacki, M. G., & Carley, D. W. (2014)., Brown norway and zucker lean rats demonstrate circadian variation in ventilation and sleep apnea., Sleep, 37(4), 715-721. doi:10.5665/sleep.3576 [doi]
    Frisbee, J. C., Goodwill, A. G., Frisbee, S. J., Butcher, J. T., Brock, R. W., Olfert, I. M., . . . Chantler, P. D. (2014)., Distinct temporal phases of microvascular rarefaction in skeletal muscle of obese zucker rats., American Journal of Physiology.Heart and Circulatory Physiology, 307(12), H1714-28. doi:10.1152/ajpheart.00605.2014 [doi]
    Gomez-Solis, A., Reyes-Esparza, J., Garcia-Vazquez, F., Alvarez-Ayala, E., & Rodriguez-Fragoso, L. (2014)., Immuno-modulator metallo-peptide reduces inflammatory state in obese zucker fa/fa rats., International Journal of Biomedical Science : IJBS, 10(3), 172-181.
    Gupta, D., Leahy, A. A., Monga, N., Peshavaria, M., Jetton, T. L., & Leahy, J. L. (2013)., Peroxisome proliferator-activated receptor gamma (PPARgamma) and its target genes are downstream effectors of FoxO1 protein in islet beta-cells: Mechanism of beta-cell compensation and failure., The Journal of Biological Chemistry, 288(35), 25440-25449. doi:10.1074/jbc.M113.486852 [doi]
    Habegger, K. M., Hoffman, N. J., Ridenour, C. M., Brozinick, J. T., & Elmendorf, J. S. (2012)., AMPK enhances insulin-stimulated GLUT4 regulation via lowering membrane cholesterol., Endocrinology, 153(5), 2130-2141. doi:10.1210/en.2011-2099 [doi]
    Hakkak, R., Al-Dwairi, A., Fuchs, G. J., Korourian, S., & Simmen, F. A. (2012)., Dietary soy protein induces hepatic lipogenic enzyme gene expression while suppressing hepatosteatosis in obese female zucker rats bearing DMBA-initiated mammary tumors., Genes & Nutrition, 7(4), 549-558. doi:10.1007/s12263-012-0294-6 [doi]
    Hakkak, R., Zeng, H., Dhakal, I. B., & Korourian, S. (2015)., Short- and long-term soy diet versus casein protects liver steatosis independent of the arginine content., Journal of Medicinal Food, doi:10.1089/jmf.2015.0002 [doi]
    Jiao, J., Bae, E. J., Bandyopadhyay, G., Oliver, J., Marathe, C., Chen, M., . . . Saberi, M. (2013), Restoration of euglycemia after duodenal bypass surgery is reliant on central and peripheral inputs in zucker fa/fa rats., Diabetes, 62(4), 1074-1083. doi:10.2337/db12-0681 [doi]
    Jin, J., Machado, E. R., Yu, H., Zhang, X., Lu, Z., Li, Y., . . . Huang, Y. (2014)., Simvastatin inhibits LPS-induced alveolar bone loss during metabolic syndrome., Journal of Dental Research, 93(3), 294-299. doi:10.1177/0022034513516980 [doi]
    Johnson, F. K., Peyton, K. J., Liu, X. M., Azam, M. A., Shebib, A. R., Johnson, R. A., & Durante, W. (2015)., Arginase promotes endothelial dysfunction and hypertension in obese rats., Obesity (Silver Spring, Md.), 23(2), 383-390. doi:10.1002/oby.20969 [doi]
    Legette, L. L., Luna, A. Y., Reed, R. L., Miranda, C. L., Bobe, G., Proteau, R. R., & Stevens, J. F. (2013)., Xanthohumol lowers body weight and fasting plasma glucose in obese male zucker fa/fa rats., Phytochemistry, 91, 236-241. doi:10.1016/j.phytochem.2012.04.018 [doi]
    Li, Y., Zhang, Y., Li, R., Chen, W., Howell, M., Zhang, R., & Chen, G. (2012)., The hepatic Raldh1 expression is elevated in zucker fatty rats and its over-expression introduced the retinal-induced srebp-1c expression in INS-1 cells., PloS One, 7(9), e45210. doi:10.1371/journal.pone.0045210 [doi]
    Li, Z., Dungan, C. M., Carrier, B., Rideout, T. C., & Williamson, D. L. (2014)., Alpha-lipoic acid supplementation reduces mTORC1 signaling in skeletal muscle from high fat fed, obese zucker rats., Lipids, 49(12), 1193-1201. doi:10.1007/s11745-014-3964-x [doi]
    Lin, D. C., Zhang, J., Zhuang, R., Li, F., Nguyen, K., Chen, M., . . . Luo, J. (2011)., AMG 837: A novel GPR40/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodents., PloS One, 6(11), e27270. doi:10.1371/journal.pone.0027270 [doi]
    Lobato, N. S., Filgueira, F. P., Prakash, R., Giachini, F. R., Ergul, A., Carvalho, M. H., . . . Fortes, Z. B. (2013)., Reduced endothelium-dependent relaxation to anandamide in mesenteric arteries from young obese zucker rats., PloS One, 8(5), e63449. doi:10.1371/journal.pone.0063449 [doi]
    Marchionne, E. M., Diamond-Stanic, M. K., Prasonnarong, M., & Henriksen, E. J. (2012)., Chronic renin inhibition with aliskiren improves glucose tolerance, insulin sensitivity, and skeletal muscle glucose transport activity in obese zucker rats., American Journal of Physiology.Regulatory, Integrative and Comparative Physiology, 302(1), R137-42. doi:10.1152/ajpregu.00448.2011 [doi]
    Mittwede, P. N., Xiang, L., Lu, S., Clemmer, J. S., & Hester, R. L. (2013)., A novel experimental model of orthopedic trauma with acute kidney injury in obese zucker rats., Physiological Reports, 1(5), e00097. doi:10.1002/phy2.97 [doi]
    Muhammad, A. B., Lokhandwala, M. F., & Banday, A. A. (2011)., Exercise reduces oxidative stress but does not alleviate hyperinsulinemia or renal dopamine D1 receptor dysfunction in obese rats., American Journal of Physiology.Renal Physiology, 300(1), F98-104. doi:10.1152/ajprenal.00386.2010 [doi]
    Murthy, S. N., Pankey, E. A., Banka, A. A., Badejo, A. M.,Jr, Wekerle, R., Vilija, V., . . . Fonseca, V. A. (2012)., Effects of insulin detemir on balloon catheter injured carotid artery in zucker fatty rats., Journal of Diabetes and its Complications, 26(6), 470-475. doi:10.1016/j.jdiacomp.2012.05.019 [doi]
    Noratto, G. D., Garcia-Mazcorro, J. F., Markel, M., Martino, H. S., Minamoto, Y., Steiner, J. M., . . . Mertens-Talcott, S. U. (2014)., Carbohydrate-free peach (prunus persica) and plum (prunus salicina) [corrected] juice affects fecal microbial ecology in an obese animal model., PloS One, 9(7), e101723. doi:10.1371/journal.pone.0101723 [doi]
    Noratto, G., Martino, H. S., Simbo, S., Byrne, D., & Mertens-Talcott, S. U. (2015)., Consumption of polyphenol-rich peach and plum juice prevents risk factors for obesity-related metabolic disorders and cardiovascular disease in zucker rats., The Journal of Nutritional Biochemistry, 26(6), 633-641. doi:10.1016/j.jnutbio.2014.12.014 [doi]
    Ochman, A. R., Lipinski, C. A., Handler, J. A., Reaume, A. G., & Saporito, M. S. (2012)., The lyn kinase activator MLR-1023 is a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes., The Journal of Pharmacology and Experimental Therapeutics, 342(1), 23-32. doi:10.1124/jpet.112.192187 [doi]
    Palacios-Gonzalez, B., Zarain-Herzberg, A., Flores-Galicia, I., Noriega, L. G., Aleman-Escondrillas, G., Zarinan, T., . . . Tovar, A. R. (2014)., Genistein stimulates fatty acid oxidation in a leptin receptor-independent manner through the JAK2-mediated phosphorylation and activation of AMPK in skeletal muscle., Biochimica Et Biophysica Acta, 1841(1), 132-140. doi:10.1016/j.bbalip.2013.08.018 [doi]
    Peterson, J. M., Mart, R., & Bond, C. E. (2014)., Effect of obesity and exercise on the expression of the novel myokines, myonectin and fibronectin type III domain containing 5., Peerj, 2, e605. doi:10.7717/peerj.605 [doi]
    Prasannarong, M., Santos, F. R., & Henriksen, E. J. (2012)., ANG-(1-7) reduces ANG II-induced insulin resistance by enhancing akt phosphorylation via a mas receptor-dependent mechanism in rat skeletal muscle., Biochemical and Biophysical Research Communications, 426(3), 369-373. doi:10.1016/j.bbrc.2012.08.093 [doi]
    Prasannarong, M., Santos, F. R., Hooshmand, P., Hooshmand, P., Giovannini, F. J., & Henriksen, E. J. (2014)., The lipid peroxidation end-product and oxidant 4-hydroxynonenal induces insulin resistance in rat slow-twitch skeletal muscle., Archives of Physiology and Biochemistry, 120(1), 22-28. doi:10.3109/13813455.2013.834937 [doi]
    Rasmussen, E. B., & Hillman, C. (2011)., Naloxone and rimonabant reduce the reinforcing properties of exercise in rats., Experimental and Clinical Psychopharmacology, 19(6), 389-400. doi:10.1037/a0024142 [doi]
    Rasmussen, E. B., Reilly, W., Buckley, J., & Boomhower, S. R. (2012)., Rimonabant reduces the essential value of food in the genetically obese zucker rat: An exponential demand analysis., Physiology & Behavior, 105(3), 734-741. doi:10.1016/j.physbeh.2011.10.009 [doi]
    Reyes-Esparza, J., Mendoza-Rivera, B., De la Cruz-Cordero, R., Duarte-Vazquez, M. A., Rosado, J. L., & Rodriguez-Fragoso, L. (2014)., Pharmacokinetic and pharmacological effects of beta-hydroxyphosphocarnitine in animal models., Pharmacology, 94(1-2), 90-98. doi:10.1159/000366205 [doi]
    Reyes-Esparza, J., Mendoza-Rivera, B., De la Cruz-Cordero, R., Rosado, J. L., Duarte-Vazquez, M. A., Solis, M. G., . . . Rodriguez-Fragoso, L. (2013)., Pharmacological evaluation of a beta-hydroxyphosphonate analogue of l-carnitine in obese zucker fa/fa rats., Basic & Clinical Pharmacology & Toxicology, 112(4), 222-228. doi:10.1111/bcpt.12019 [doi]
    Rideout, T. C., Carrier, B., Wen, S., Raslawsky, A., Browne, R. W., & Harding, S. V. (2015)., Complementary cholesterol-lowering response of a Phytosterol/alpha-lipoic acid combination in obese zucker rats., Journal of Dietary Supplements, doi:10.3109/19390211.2015.1008616 [doi]
    Samuel, P., Ali, Q., Sabuhi, R., Wu, Y., & Hussain, T. (2012)., High na intake increases renal angiotensin II levels and reduces expression of the ACE2-AT(2)R-MasR axis in obese zucker rats., American Journal of Physiology.Renal Physiology, 303(3), F412-9. doi:10.1152/ajprenal.00097.2012 [doi]
    Schade, K. N., Baranwal, A., Liang, C., Mirbolooki, M. R., & Mukherjee, J. (2015)., Preliminary evaluation of beta3-adrenoceptor agonist-induced 18F-FDG metabolic activity of brown adipose tissue in obese zucker rat., Nuclear Medicine and Biology, 42(8), 691-694. doi:10.1016/j.nucmedbio.2015.04.003 [doi]
    Slyvka, Y., Wang, Z., Yee, J., Inman, S. R., & Nowak, F. V. (2011)., Antioxidant diet, gender and age affect renal expression of nitric oxide synthases in obese diabetic rats., Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society, 24(1), 50-60. doi:10.1016/j.niox.2010.11.004 [doi]
    Thanos, P. K., Robison, L. S., Robinson, J. K., Michaelides, M., Wang, G. J., & Volkow, N. D. (2013)., Obese rats with deficient leptin signaling exhibit heightened sensitivity to olfactory food cues., Synapse (New York, N.Y.), 67(4), 171-178. doi:10.1002/syn.21627 [doi]
    Tovar-Palacio, C., Tovar, A. R., Torres, N., Cruz, C., Hernandez-Pando, R., Salas-Garrido, G., . . . Correa-Rotter, R. (2011)., Proinflammatory gene expression and renal lipogenesis are modulated by dietary protein content in obese zucker fa/fa rats., American Journal of Physiology.Renal Physiology, 300(1), F263-71. doi:10.1152/ajprenal.00171.2010 [doi]
    Townsend, E. A., Beloate, L. N., Huskinson, S. L., Roma, P. G., & Freeman, K. B. (2015)., Corn oil, but not cocaine, is a more effective reinforcer in obese than in lean zucker rats., Physiology & Behavior, 143, 136-141. doi:10.1016/j.physbeh.2015.03.002 [doi]
    Uthus, E. O., & Picklo MJ, S. (2011)., Obesity reduces methionine sulphoxide reductase activity in visceral adipose tissue., Free Radical Research, 45(9), 1052-1060. doi:10.3109/10715762.2011.591793 [doi]
    Washington, M. C., Park, K. H., & Sayegh, A. I. (2014)., Obese and lean zucker rats respond similarly to intraperitoneal administration of gastrin-releasing peptides., Peptides, 58, 36-41. doi:10.1016/j.peptides.2014.04.020 [doi]
    Wickramasekara, S. I., Zandkarimi, F., Morre, J., Kirkwood, J., Legette, L., Jiang, Y., . . . Maier, C. S. (2013), Electrospray quadrupole travelling wave ion mobility time-of-flight mass spectrometry for the detection of plasma metabolome changes caused by xanthohumol in obese zucker (fa/fa) rats., Metabolites, 3(3), 701-717. doi:10.3390/metabo3030701 [doi]
    Xiang, L., Clemmer, J. S., Lu, S., & Mittwede, P. N. (2013)., Impaired blood pressure compensation following hemorrhage in conscious obese zucker rats., Life Sciences, 93(5-6), 214-219. doi:10.1016/j.lfs.2013.06.006 [doi]
    Xiang, L., Lu, S., Fuller, W., Aneja, A., Russell, G. V., Jones, L. B., & Hester, R. (2012)., Impaired blood pressure recovery to hemorrhage in obese zucker rats with orthopedic trauma. American Journal of Physiology., Heart and Circulatory Physiology, 302(1), H340-8. doi:10.1152/ajpheart.00439.2011 [doi]
    Zhan, Y., Shi, H., Caligiuri, S. P., Wu, Y., Declercq, V., Taylor, C. G., . . . Aukema, H. M. (2015)., Trans-10,cis-12-conjugated linoleic acid worsens renal pathology and alters cyclooxygenase derived oxylipins in obesity-associated nephropathy., The Journal of Nutritional Biochemistry, 26(2), 130-137. doi:10.1016/j.jnutbio.2014.09.011 [doi]
    Zhang, Q., Celestino, J., Schmandt, R., McCampbell, A. S., Urbauer, D. L., Meyer, L. A., . . . Lu, K. H. (2013)., Chemopreventive effects of metformin on obesity-associated endometrial proliferation., American Journal of Obstetrics and Gynecology, 209(1), 24.e1-24.e12. doi:10.1016/j.ajog.2013.03.008 [doi]
    Zhang, Y., Chen, W., Li, R., Li, Y., Ge, Y., & Chen, G. (2011)., Insulin-regulated srebp-1c and Pck1 mRNA expression in primary hepatocytes from zucker fatty but not lean rats is affected by feeding conditions., PloS One, 6(6), e21342. doi:10.1371/journal.pone.0021342 [doi]

    Obesity

    Ali, Q., Patel, S., & Hussain, T. (2015)., Angiotensin AT2 receptor agonist prevents salt-sensitive hypertension in obese zucker rats., American Journal of Physiology.Renal Physiology, 308(12), F1379-85. doi:10.1152/ajprenal.00002.2015 [doi]
    Ali, Q., Wu, Y., & Hussain, T. (2013)., Chronic AT2 receptor activation increases renal ACE2 activity, attenuates AT1 receptor function and blood pressure in obese zucker rats., Kidney International, 84(5), 931-939. doi:10.1038/ki.2013.193 [doi]