CLOSE ×

Gene therapy

Vandergaast, Rianna; Khongwichit, Sarawut; Jiang, Huailei; DeGrado, Timothy R; Peng, Kah-Whye; Smith, Duncan R; Russell, Stephen J; Suksanpaisan, Lukkana, Enhanced noninvasive imaging of oncology models using the NIS reporter gene and bioluminescence imaging., Cancer gene therapy Vol.14, 2019

General studies

Taglialegna, Agustina; Varela, Maria C; Rosato, Roberto R; Rosato, Adriana E;, VraSR and Virulence Trait Modulation during Daptomycin Resistance in Methicillin-Resistant Staphylococcus aureus Infection, mSphere Vol.4, 2019

Immunology

Liu, B., Kong, L., Han, K., Hong, H., Marcus, W. D., Chen, X., . . . Wong, H. C. (2016)., A novel fusion of ALT-803 (interleukin (IL)-15 superagonist) with an antibody demonstrates antigen-specific antitumor responses, The Journal of Biological Chemistry, 291(46), 23869-23881. doi:M116
Izhak, L., Wildbaum, G., Zohar, Y., Anunu, R., Klapper, L., Elkeles, A., . . . Karin, N. (2009)., A novel recombinant fusion protein encoding a 20-amino acid residue of the third extracellular (E3) domain of CCR2 neutralizes the biological activity of CCL2., Journal of Immunology (Baltimore, Md.: 1950), 183(1), 732-739. doi:10.4049/jimmunol.0802746 [doi]
Stangl, S., Wortmann, A., Guertler, U., & Multhoff, G. (2006), Control of metastasized pancreatic carcinomas in SCID/beige mice with human IL-2/TKD-activated NK cells., . Journal of Immunology (Baltimore, Md.: 1950), 176(10), 6270-6276. doi:176/10/6270 [pii]
Porkka, K., Koskenvesa, P., Lundan, T., Rimpilainen, J., Mustjoki, S., Smykla, R., . . . Lee, F. Y. (2008), Dasatinib crosses the blood-brain barrier and is an efficient therapy for central nervous system philadelphia chromosome-positive leukemia., Blood, 112(4), 1005-1012. doi:10.1182/blood-2008-02-140665 [doi]
Brown, M. E., Rondon, E., Rajesh, D., Mack, A., Lewis, R., Feng, X., . . . Nuwaysir, E. F. (2010)., Derivation of induced pluripotent stem cells from human peripheral blood T lymphocytes. PloS, PloS One, 5(6), e11373. doi:10.1371/journal.pone.0011373 [doi]
Gavrilov, S., Marolt, D., Douglas, N. C., Prosser, R. W., Khalid, I., Sauer, M. V., . . . Papaioannou, V. E. (2011), Derivation of two new human embryonic stem cell lines from nonviable human embryos., Stem Cells International, 2011, 765378. doi:10.4061/2011/765378 [doi]
Yipp, B. G., Hickey, M. J., Andonegui, G., Murray, A. G., Looareesuwan, S., Kubes, P., & Ho, M. (2007)., Differential roles of CD36, ICAM-1, and P-selectin in plasmodium falciparum cytoadherence in vivo., Microcirculation (New York, N.Y.: 1994), 14(6), 593-602. doi:781394714 [pii]
Mueller, K., Schweier, O., & Pircher, H. (2008)., Efficacy of IL-2- versus IL-15-stimulated CD8 T cells in adoptive immunotherapy, European Journal of Immunology, 38(10), 2874-2885. doi:10.1002/eji.200838426 [doi]
Domev, H., Amit, M., Laevsky, I., Dar, A., & Itskovitz-Eldor, J. (2012), Efficient engineering of vascularized ectopic bone from human embryonic stem cell-derived mesenchymal stem cells., Tissue Engineering.Part A, 18(21-22), 2290-2302. doi:10.1089/ten.TEA.2011.0371 [doi]
Yu, J., Chau, K. F., Vodyanik, M. A., Jiang, J., & Jiang, Y. (2011)., Efficient feeder-free episomal reprogramming with small molecules, PloS One, 6(3), e17557. doi:10.1371/journal.pone.0017557 [doi]
Mack, A. A., Kroboth, S., Rajesh, D., & Wang, W. B. (2011)., Generation of induced pluripotent stem cells from CD34+ cells across blood drawn from multiple donors with non-integrating episomal vectors., PloS One, 6(11), e27956. doi:10.1371/journal.pone.0027956 [doi]
Kalac, M., Scotto, L., Marchi, E., Amengual, J., Seshan, V. E., Bhagat, G., . . . O'Connor, O. A. (2011)., HDAC inhibitors and decitabine are highly synergistic and associated with unique gene-expression and epigenetic profiles in models of DLBCL., Blood, 118(20), 5506-5516. doi:10.1182/blood-2011-02-336891 [doi]
Brignole, C., Pastorino, F., Marimpietri, D., Pagnan, G., Pistorio, A., Allen, T. M., . . . Ponzoni, M. (2004)., Immune cell-mediated antitumor activities of GD2-targeted liposomal c-myb antisense oligonucleotides containing CpG motifs., Journal of the National Cancer Institute, 96(15), 1171-1180. doi:10.1093/jnci/djh221 [doi]
Kim, Ik Sun; Gao, Yang; Welte, Thomas; Wang, Hai; Liu, Jun; Janghorban, Mahnaz; Sheng, Kuanwei; Niu, Yichi; Goldstein, Amit; Zhao, Na; Bado, Igor; Lo, Hin-Ching; Toneff, Michael J; Nguyen, Tuan; Bu, Wen; Jiang, Weiyu; Arnold, James; Gu, Franklin; He, Jian; Jebakumar, Deborah; Walker, Kimberly; Li, Yi; Mo, Qianxing; Westbrook, Thomas F; Zong, Chenghang; Rao, Arundhati; Sreekumar, Arun; Rosen, Jeffrey M; Zhang, Xiang H-F;, Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms., Nature cell biology Vol.21, 2019
Lum, H. D., Buhtoiarov, I. N., Schmidt, B. E., Berke, G., Paulnock, D. M., Sondel, P. M., & Rakhmilevich, A. L. (2006, In vivo CD40 ligation can induce T-cell-independent antitumor effects that involve macrophages., Journal of Leukocyte Biology, 79(6), 1181-1192. doi:jlb.0405191 [pii]
Keren, Aviad; Gilhar, Amos; Ullmann, Yehuda; Zlotkin-Frušić, Marina; Soroka, Yoram; Domb, Abraham J; Levite, Mia;, Instantaneous depolarization of T cells via dopamine receptors, and inhibition of activated T cells of Psoriasis patients and inflamed human skin, by D1-like receptor agonist, Immunology Vol.158, 2019
Bruin, J. E., Rezania, A., Xu, J., Narayan, K., Fox, J. K., O'Neil, J. J., & Kieffer, T. J. (2013)., Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice., Diabetologia, 56(9), 1987-1998. doi:10.1007/s00125-013-2955-4 [doi]
Timaner, Michael; Kotsofruk, Ruslana; Raviv, Ziv; Magidey, Ksenia; Shechter, Dvir; Kan, Tal; Nevelsky, Alexander; Daniel, Shahar; de Vries, Elisabeth G E; Zhang, Tongwu; Kaidar-Person, Orit; Kerbel, Robert S; Shaked, Yuval;, Microparticles from tumors exposed to radiation promote immune evasion in part by PD-L1., Oncogene Vol.39, 2020
Felder M, Kapur A, Rakhmilevich AL, Qu X, Sondel PM, Gillies SD, Connor J, Patankar MS., MUC16 suppresses human and murine innate immune responses, Gynecol Oncol. 2019 Mar;152(3):618-628.
Di Gialleonardo, V., Signore, A., Glaudemans, A. W., Dierckx, R. A., & De Vries, E. F. (2012)., N-(4-18F-fluorobenzoyl)interleukin-2 for PET of human-activated T lymphocytes., Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine, 53(5), 679-686. doi:10.2967/jnumed.111.091306 [doi]
Suttmann, H., Riemensberger, J., Bentien, G., Schmaltz, D., Stockle, M., Jocham, D., . . . Brandau, S. (2006)., Neutrophil granulocytes are required for effective bacillus calmette-guerin immunotherapy of bladder cancer and orchestrate local immune responses., Cancer Research, 66(16), 8250-8257. doi:66/16/8250 [pii]
Fajardo, C. A., Guedan, S., Rojas, L. A., Moreno, R., Arias-Badia, M., de Sostoa, J., . . . Alemany, R. (2017)., Oncolytic adenoviral delivery of an EGFR-targeting T-cell engager improves antitumor efficacy, Cancer Research, 77(8), 2052-2063. doi:10.1158/0008-5472.CAN-16-1708 [doi]
Revazova, E. S., Turovets, N. A., Kochetkova, O. D., Kindarova, L. B., Kuzmichev, L. N., Janus, J. D., & Pryzhkova, M. V. (2007)., Patient-specific stem cell lines derived from human parthenogenetic blastocysts., Cloning and Stem Cells, 9(3), 432-449. doi:10.1089/clo.2007.0033 [doi]
Holland, M., Castro, F. V., Alexander, S., Smith, D., Liu, J., Walker, M., . . . Saha, V. (2011), RAC2, AEP, and ICAM1 expression are associated with CNS disease in a mouse model of pre-B childhood acute lymphoblastic leukemia, Blood, 118(3), 638-649. doi:10.1182/blood-2010-09-307330 [doi]
Balza, E., Mortara, L., Sassi, F., Monteghirfo, S., Carnemolla, B., Castellani, P., . . . Borsi, L. (2006)., Targeted delivery of tumor necrosis factor-alpha to tumor vessels induces a therapeutic T cell-mediated immune response that protects the host against syngeneic tumors of different histologic origin, Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 12(8), 2575-2582. doi:12/8/2575 [pii]
Straetemans, T., Coccoris, M., Berrevoets, C., Treffers-Westerlaken, E., Scholten, C. E., Schipper, D., . . . Debets, R. (2012)., T-cell receptor gene therapy in human melanoma-bearing immune-deficient mice: Human but not mouse T cells recapitulate outcome of clinical studies, Human Gene Therapy, 23(2), 187-201. doi:10.1089/hum.2010.126 [doi]
Elsner, L., Muppala, V., Gehrmann, M., Lozano, J., Malzahn, D., Bickeboller, H., . . . Dressel, R. (2007)., The heat shock protein HSP70 promotes mouse NK cell activity against tumors that express inducible NKG2D ligands, Journal of Immunology (Baltimore, Md.: 1950), 179(8), 5523-5533. doi:179/8/5523 [pii]
Wu, Q. L., Buhtoiarov, I. N., Sondel, P. M., Rakhmilevich, A. L., & Ranheim, E. A. (2009)., Tumoricidal effects of activated macrophages in a mouse model of chronic lymphocytic leukemia., Journal of Immunology (Baltimore, Md.: 1950), 182(11), 6771-6778. doi:10.4049/jimmunol.0801847 [doi]

Oncology

Le Joncour, Vadim; Martins, Ana; Puhka, Maija; Isola, Jorma; Salmikangas, Marko; Laakkonen, Pirjo; Joensuu, Heikki; Barok, Mark;, A Novel Anti-HER2 Antibody-Drug Conjugate XMT-1522 for HER2-Positive Breast and Gastric Cancers Resistant to Trastuzumab Emtansine., Molecular cancer therapeutics Vol.18, 2019
Czardybon, W., Windak, R., Golas, A., Galezowski, M., Sabiniarz, A., Dolata, I., . . . Brzozka, K. (2018), A novel, dual pan-PIM/FLT3 inhibitor SEL24 exhibits broad therapeutic potential in acute myeloid leukemia., Oncotarget, 9(24), 16917-16931. doi:10.18632/oncotarget.24747 [doi]
Zaffran I, Landolina N, Gaur P, Rovis TL, Stipan J, Mandelboim O, Singer BB, Levi-Schaffer F., Activation of CEACAM1 with an agonistic monoclonal antibody results in inhibition of melanoma cells, Cancer Gene Ther. 2022 Nov;29(11):1676-1685. doi: 10.1038/s41417-022-00486-x. Epub 2022 Jun 9.
Landolina N, Zaffran I, Smiljkovic D, Serrano-Candelas E, Schmiedel D, Friedman S, Arock M, Hartmann K, Pikarsky E, Mandelboim O, Martin M, Valent P, Levi-Schaffer F., Activation of Siglec-7 results in inhibition of in vitro and in vivo growth of human mast cell leukemia cells, Pharmacol Res. 2020 Aug;158:104682. doi: 10.1016/j.phrs.2020.104682. Epub 2020 Feb 5.
Kelly, R. K., Olson, D. L., Sun, Y., Wen, D., Wortham, K. A., Antognetti, G., . . . Sanicola, M. (2011), An antibody-cytotoxic conjugate, BIIB015, is a new targeted therapy for cripto positive tumours., . European Journal of Cancer (Oxford, England : 1990), 47(11), 1736-1746. doi:10.1016/j.ejca.2011.02.023 [doi]
Urbinati, G., Ali, H. M., Rousseau, Q., Chapuis, H., Desmaele, D., Couvreur, P., & Massaad-Massade, L. (2015)., Antineoplastic effects of siRNA against TMPRSS2-ERG junction oncogene in prostate cancer., PloS One, 10(5), e0125277. doi:10.1371/journal.pone.0125277 [doi]
Adepoju, L. J., & Geiger, J. D. (2010). ., Antitumor activity of polyuridylic acid in human soft tissue and bone sarcomas., The Journal of Surgical Research, 164(1), e107-14. doi:10.1016/j.jss.2010.05.038 [doi]
Egberts, J. H., Cloosters, V., Noack, A., Schniewind, B., Thon, L., Klose, S., . . . Trauzold, A., Anti-tumor necrosis factor therapy inhibits pancreatic tumor growth and metastasis., Cancer Research, 68(5), 1443-1450. doi:10.1158/0008-5472.CAN-07-5704 [doi]
Zhao, Ning; Peacock, Stephanie O; Lo, Chen Hao; Heidman, Laine M; Rice, Meghan A; Fahrenholtz, Cale D; Greene, Ann M; Magani, Fiorella;, Arginine vasopressin receptor 1a is a therapeutic target for castration-resistant prostate cancer., Science translational medicine Vol.11, 2019
Wei J, Yin L, Li J, Wang J, Pu T, Duan P, Lin TP, Gao AC, Wu BJ., Bidirectional Cross-talk between MAOA and AR Promotes Hormone-Dependent and Castration-Resistant Prostate Cancer, Cancer Res. 2021 Aug 15;81(16):4275-4289. doi: 10.1158/0008-5472.CAN-21-0198. Epub 2021 Jun 24.
Biswas N, Abu Ammar A, Frušić-Zlotkin M, Adi-Hen N, Lehman-Katabi Y, Levi-Kalisman Y, Nassar T, Benita S., Biodistribution and efficacy of the anticancer drug, oxaliplatin palmitate acetate, in mice, Int J Pharm. 2021 Jul 15;604:120740. doi: 10.1016/j.ijpharm.2021.120740. Epub 2021 May 29.
Parhi L, Alon-Maimon T, Sol A, Nejman D, Shhadeh A, Fainsod-Levi T, Yajuk O, Isaacson B, Abed J, Maalouf N, Nissan A, Sandbank J, Yehuda-Shnaidman E, Ponath F, Vogel J, Mandelboim O, Granot Z, Straussman R, Bachrach G., Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression, Nat Commun. 2020 Jun 26;11(1):3259. doi: 10.1038/s41467-020-16967-2.
von Karstedt, S., Conti, A., Nobis, M., Montinaro, A., Hartwig, T., Lemke, J., . . . Walczak, H. (2015)., Cancer cell-autonomous TRAIL-R signaling promotes KRAS-driven cancer progression, invasion, and metastasis., Cancer Cell, 27(4), 561-573. doi:10.1016/j.ccell.2015.02.014 [doi]
Pesakhov, S., Nachliely, M., Barvish, Z., Aqaqe, N., Schwartzman, B., Voronov, E., . . . Danilenko, M. (2016), Cancer-selective cytotoxic Ca2+ overload in acute myeloid leukemia cells and attenuation of disease progression in mice by synergistically acting polyphenols curcumin and carnosic acid, Oncotarget, 7(22), 31847-31861. doi:10.18632/oncotarget.7240 [doi]
Assimon VA, Tang Y, Vargas JD, Lee GJ, Wu ZY, Lou K, Yao B, Menon MK, Pios A, Perez KC, Madriaga A, Buchowiecki PK, Rolfe M, Shawver L, Jiao X, Le Moigne R, Zhou HJ, Anderson DJ, CB-6644 Is a Selective Inhibitor of the RUVBL1/2 Complex with Anticancer Activity., ACS Chem Biol. 2019 Feb 15;14(2):236-244.
Rakhmilevich, A. L., Buhtoiarov, I. N., Malkovsky, M., & Sondel, P. M. (2008)., CD40 ligation in vivo can induce T cell independent antitumor effects even against immunogenic tumors., Cancer Immunology, Immunotherapy : CII, 57(8), 1151-1160. doi:10.1007/s00262-007-0447-4 [doi]
Hurley RM, McGehee CD, Nesic K, Correia C, Weiskittel TM, Kelly RL, Venkatachalam A, Hou X, Pathoulas NM, Meng XW, Kondrashova O, Radke MR, Schneider PA, Flatten KS, Peterson KL, Becker MA, Wong EM, Southey MS, Dobrovic A, Lin KK, Harding TC, McNeish I, Ross CA, Wagner JM, Wakefield MJ, Scott CL, Haluska P, Wahner Hendrickson AE, Karnitz LM, Swisher EM, Li H, Weroha SJ, Kaufmann SH., Characterization of a RAD51C-silenced high-grade serous ovarian cancer model during development of PARP inhibitor resistance, NAR Cancer. 2021 Jul 9;3(3):zcab028. doi: 10.1093/narcan/zcab028. eCollection 2021 Sep.
Sobot, D., Mura, S., Rouquette, M., Vukosavljevic, B., Cayre, F., Buchy, E., . . . Couvreur, P. (2017)., Circulating lipoproteins: A trojan horse guiding squalenoylated drugs to LDL-accumulating cancer cells., Molecular Therapy : The Journal of the American Society of Gene Therapy, 25(7), 1596-1605. doi:S1525-0016(17)30234-4 [pii]
Kaeopookum, Piriya; Petrik, Milos; Summer, Dominik; Klinger, Maximilian; Zhai, Chuangyan; Rangger, Christine; Haubner, Roland; Haas, Hubertus; Hajduch, Marian; Decristoforo, Clemens;, Comparison of 68Ga-labeled RGD mono- and multimers based on a clickable siderophore-based scaffold., Nuclear medicine and biology Vol.78-79,
Liu D, Hou X, Wu W, Zanfagnin V, Li Y, Correia C, Zhao Z, Zhao C, Liu Z, Zhang T, Fang Z, Wang H, Xu C, Weroha SJ, Kaufmann SH, Dai H., Constitutive BAK/MCL1 complexes predict paclitaxel and S63845 sensitivity of ovarian cancer, Cell Death Dis. 2021 Aug 12;12(8):789. doi: 10.1038/s41419-021-04073-0.
Stangl, S., Wortmann, A., Guertler, U., & Multhoff, G. (2006)., Control of metastasized pancreatic carcinomas in SCID/beige mice with human IL-2/TKD-activated NK cells., Journal of Immunology (Baltimore, Md.: 1950), 176(10), 6270-6276. doi:176/10/6270 [pii]
Glaser, G., Weroha, S. J., Becker, M. A., Hou, X., Enderica-Gonzalez, S., Harrington, S. C., & Haluska, P. (2015)., Conventional chemotherapy and oncogenic pathway targeting in ovarian carcinosarcoma using a patient-derived tumorgraft., PloS One, 10(5), e0126867. doi:10.1371/journal.pone.0126867 [doi]
Bartalucci, N., Tozzi, L., Bogani, C., Martinelli, S., Rotunno, G., Villeval, J. L., & Vannucchi, A. M. (2013)., Co-targeting the PI3K/mTOR and JAK2 signalling pathways produces synergistic activity against myeloproliferative neoplasms., Journal of Cellular and Molecular Medicine, 17(11), 1385-1396. doi:10.1111/jcmm.12162 [doi]
Egberts, J. H., Schniewind, B., Patzold, M., Kettler, B., Tepel, J., Kalthoff, H., & Trauzold, A. (2008)., Dexamethasone reduces tumor recurrence and metastasis after pancreatic tumor resection in SCID mice., Cancer Biology & Therapy, 7(7), 1044-1050. doi:6099 [pii]
Nachliely M, Trachtenberg A, Khalfin B, Nalbandyan K, Cohen-Lahav M, Yasuda K, Sakaki T, Kutner A, Danilenko M., Dimethyl fumarate and vitamin D derivatives cooperatively enhance VDR and Nrf2 signaling in differentiating AML cells in vitro and inhibit leukemia progression in a xenograft mouse model., . J Steroid Biochem Mol Biol. 2019 Apr;188:8-16
Hiriyan, J., Shivarudraiah, P., Gavara, G., Annamalai, P., Natesan, S., Sambasivam, G., & Sukumaran, S. K. (2015)., Discovery of PAT-1102, a novel, potent and orally active histone deacetylase inhibitor with antitumor activity in cancer mouse models, Anticancer Research, 35(1), 229-237. doi:35/1/229 [pii]
Fonti, Claire; Saumet, Anne; Abi-Khalil, Amanda; Orsetti, Béatrice; Cleroux, Elouan; Bender, Ambre; Dumas, Michael; Schmitt, Emeline; Colinge, Jacques; Jacot, William; Weber, Michael; Sardet, Claude; du Manoir, Stanislas; Theillet, Charles;, Distinct oncogenes drive different genome and epigenome alterations in human mammary epithelial cells, International journal of cancer Vol.145, 2019
Potter DS, Du R, Bhola P, Bueno R, Letai A., Dynamic BH3 profiling identifies active BH3 mimetic combinations in non-small cell lung cancer, Cell Death Dis. 2021 Jul 27;12(8):741. doi: 10.1038/s41419-021-04029-4.
Potter DS, Du R, Bohl SR, Chow KH, Ligon KL, Bueno R, Letai A., Dynamic BH3 profiling identifies pro-apoptotic drug combinations for the treatment of malignant pleural mesothelioma., Nat Commun. 2023 May 20;14(1):2897. doi: 10.1038/s41467-023-38552-z.
Key, J., Aryal, S., Gentile, F., Ananta, J. S., Zhong, M., Landis, M. D., & Decuzzi, P. (2013)., Engineering discoidal polymeric nanoconstructs with enhanced magneto-optical properties for tumor imaging, Biomaterials, 34(21), 5402-5410. doi:10.1016/j.biomaterials.2013.03.078 [doi]
Natoni, A., Smith, T. A. G., Keane, N., McEllistrim, C., Connolly, C., Jha, A., . . . O'Dwyer, M. E. (2017)., E-selectin ligands recognised by HECA452 induce drug resistance in myeloma, which is overcome by the E-selectin antagonist, GMI-1271., Leukemia, 31(12), 2642-2651. doi:10.1038/leu.2017.123 [doi]
De Thaye E, Van de Vijver K, Van der Meulen J, Taminau J, Wagemans G, Denys H, Van Dorpe J, Berx G, Ceelen W, Van Bocxlaer J, De Wever O., Establishment and characterization of a cell line and patient-derived xenograft (PDX) from peritoneal metastasis of low-grade serous ovarian carcinoma, Sci Rep. 2020 Apr 21;10(1):6688. doi: 10.1038/s41598-020-63738-6.
Naumann, C. M., Sperveslage, J., Hamann, M. F., Leuschner, I., Weder, L., Al-Najar, A. A., . . . Kalthoff, H. (2012)., Establishment and characterization of primary cell lines of squamous cell carcinoma of the penis and its metastasis., The Journal of Urology, 187(6), 2236-2242. doi:10.1016/j.juro.2012.01.035 [doi]
Srivastava, Swati; Nataraj, Nishanth Belugali; Sekar, Arunachalam; Ghosh, Soma; Bornstein, Chamutal; Drago-Garcia, Diana; Roth, Lee; Romaniello, Donatella; Marrocco, Ilaria; David, Eyal; Gilad, Yuval; Lauriola, Mattia; Rotkopf, Ron; Kimchi, Adi; Haga, Yuya; Tsutsumi, Yasuo; Mirabeau, Olivier; Surdez, Didier; Zinovyev, Andrei; Delattre, Olivier; Kovar, Heinrich; Amit, Ido; Yarden, Yosef;, ETS Proteins Bind with Glucocorticoid Receptors: Relevance for Treatment of Ewing Sarcoma, Cell reports Vol.29, 2019
Owonikoko, Taofeek K; Zhang, Guojing; Lallani, Shenila B; Chen, Zhengjia; Martinson, Deborah E; Khuri, Fadlo R; Lonial, Sagar; Marcus, Adam; Sun, Shi-Yong;, Evaluation of preclinical efficacy of everolimus and pasireotide in thyroid cancer cell lines and xenograft models., PloS one Vol.14, 2019
Bailey, K. M., Cornnell, H. H., Ibrahim-Hashim, A., Wojtkowiak, J. W., Hart, C. P., Zhang, X., . . . Gillies, R. J. (2014)., Evaluation of the "steal" phenomenon on the efficacy of hypoxia activated prodrug TH-302 in pancreatic cancer., PloS One, 9(12), e113586. doi:10.1371/journal.pone.0113586 [doi]
Cody, J. J., Rivera, A. A., Lyons, G. R., Yang, S. W., Wang, M., Ashley, J. W., . . . Douglas, J. T. (2013)., Expression of osteoprotegerin from a replicating adenovirus inhibits the progression of prostate cancer bone metastases in a murine model., Laboratory Investigation; a Journal of Technical Methods and Pathology, 93(3), 268-278. doi:10.1038/labinvest.2012.179 [doi]
Ronca R, Ghedini GC, Maccarinelli F, Sacco A, Locatelli SL, Foglio E, Taranto S, Grillo E, Matarazzo S, Castelli R, Paganini G, Desantis V, Cattane N, Cattaneo A, Mor M, Carlo-Stella C, Belotti A, Roccaro AM, Presta M, Giacomini A., FGF Trapping Inhibits Multiple Myeloma Growth through c-Myc Degradation-Induced Mitochondrial Oxidative Stress, Cancer Res. 2020 Jun 1;80(11):2340-2354. doi: 10.1158/0008-5472.CAN-19-2714. Epub 2020 Feb 24.
Dahis, D., Azagury, D.M., Obeid, F., Dion, M.Z., Cryer, A.M., Riquelme, M.A., Dosta, P., Abraham, A.W., Gavish, M., Artzi, N. and Shamay, Y., Focused Ultrasound Enhances Brain Delivery of Sorafenib Nanoparticles, Advanced NanoBiomed Research, 3(2), p.2200142.
Kurdow, R., Boehle, A. S., Haye, S., Boenicke, L., Schniewind, B., Dohrmann, P., & Kalthoff, H. (2002)., Ganciclovir prodrug therapy is effective in a murine xenotransplant model of human lung cancer, The Annals of Thoracic Surgery, 73(3), 905-910.
von Forstner, C., Egberts, J. H., Ammerpohl, O., Niedzielska, D., Buchert, R., Mikecz, P., . . . Brenner, W. (2008)., Gene expression patterns and tumor uptake of 18F-FDG, 18F-FLT, and 18F-FEC in PET/MRI of an orthotopic mouse xenotransplantation model of pancreatic cancer., Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine, 49(8), 1362-1370. doi:10.2967/jnumed.107.050021 [doi]
Ding, H., Peterson, K. L., Correia, C., Koh, B., Schneider, P. A., Nowakowski, G. S., & Kaufmann, S. H. (2017)., Histone deacetylase inhibitors interrupt HSP90*RASGRP1 and HSP90*CRAF interactions to upregulate BIM and circumvent drug resistance in lymphoma cells, Leukemia, 31(7), 1593-1602. doi:10.1038/leu.2016.357 [doi]
Debeb, B. G., Lacerda, L., Xu, W., Larson, R., Solley, T., Atkinson, R., . . . Woodward, W. A. (2012)., Histone deacetylase inhibitors stimulate dedifferentiation of human breast cancer cells through WNT/beta-catenin signaling., Stem Cells (Dayton, Ohio), 30(11), 2366-2377. doi:10.1002/stem.1219 [doi]
Gatto, F., Redaelli, D., Salvade, A., Marzorati, S., Sacchetti, B., Ferina, C., . . . Serafini, M. (2012)., Hurler disease bone marrow stromal cells exhibit altered ability to support osteoclast formation., Stem Cells and Development, 21(9), 1466-1477. doi:10.1089/scd.2011.0555 [doi]
Lipnik, K., Greco, O., Scott, S., Knapp, E., Mayrhofer, E., Rosenfellner, D., . . . Hohenadl, C. (2006)., Hypoxia- and radiation-inducible, breast cell-specific targeting of retroviral vectors, Virology, 349(1), 121-133. doi:S0042-6822(05)00851-2 [pii]
Feng, Yongmei; Sessions, E Hampton; Zhang, Fan; Ban, Fuqiang; Placencio-Hickok, Veronica; Ma, Chen-Ting; Zeng, Fu-Yue; Pass, Ian; Terry, David B; Cadwell, Gregory; Bankston, Laurie A; Liddington, Robert C; Chung, Thomas D Y; Pinkerton, Anthony B; Sergienko, Eduard; Gleave, Martin; Bhowmick, Neil A; Jackson, Michael R; Cherkasov, Artem; Ronai, Zeev A;, Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells., Cancer letters Vol.449, 2019
Lin ZP, Al Zouabi NN, Xu ML, Bowen NE, Wu TL, Lavi ES, Huang PH, Zhu YL, Kim B, Ratner ES., In silico screening identifies a novel small molecule inhibitor that counteracts PARP inhibitor resistance in ovarian cancer, Sci Rep. 2021 Apr 13;11(1):8042. doi: 10.1038/s41598-021-87325-5.
Potter, D. S., Galvin, M., Brown, S., Lallo, A., Hodgkinson, C. L., Blackhall, F., . . . Dive, C. (2016)., Inhibition of PI3K/BMX cell survival pathway sensitizes to BH3 mimetics in SCLC, Molecular Cancer Therapeutics, 15(6), 1248-1260. doi:10.1158/1535-7163.MCT-15-0885 [doi]
Gill, S. E., Zhang, Q., Keeney, G. L., Cliby, W. A., & Weroha, S. J. (2017)., Investigation of factors affecting the efficacy of 3C23K, a human monoclonal antibody targeting MISIIR, Oncotarget, 8(49), 85214-85223. doi:10.18632/oncotarget.19620 [doi]
Gou X, Kim BJ, Anurag M, Lei JT, Young MN, Holt MV, Fandino D, Vollert CT, Singh P, Alzubi MA, Malovannaya A, Dobrolecki LE, Lewis MT, Li S, Foulds CE, Ellis MJ., Kinome Reprogramming Is a Targetable Vulnerability in ESR1 Fusion-Driven Breast Cancer., Cancer Res. 2023 Oct 2;83(19):3237-3251. doi: 10.1158/0008-5472.CAN-22-3484.
Bartnicka JJ, Al-Salemee F, Firth G, Blower PJ., L-Cysteine-mediated modulation of copper trafficking in prostate cancer cells: an in vitro and in vivo investigation with (64)Cu and (64)Cu-PET, Metallomics. 2020 Oct 21;12(10):1508-1520. doi: 10.1039/d0mt00161a.
Gabay M, Weizman A, Zeineh N, Kahana M, Obeid F, Allon N, Gavish M., Liposomal Carrier Conjugated to APP-Derived Peptide for Brain Cancer Treatment, Cell Mol Neurobiol. 2020 Oct 6. doi: 10.1007/s10571-020-00969-1. Online ahead of print.
Stein, U., Walther, W., Arlt, F., Schwabe, H., Smith, J., Fichtner, I., . . . Schlag, P. M. (2009)., MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis, . Nature Medicine, 15(1), 59-67. doi:10.1038/nm.1889 [doi]
Wang, Wei; Shen, Tao; Dong, Bingning; Creighton, Chad J; Meng, Yanling; Zhou, Wolong; Shi, Qing; Zhou, Hao; Zhang, Yinjie; Moore, David D; Yang, Feng, MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling., The Journal of clinical investigation Vol.129, 2019
Shen T, Wang W, Zhou W, Coleman I, Cai Q, Dong B, Ittmann MM, Creighton CJ, Bian Y, Meng Y, Rowley DR, Nelson PS, Moore DD, Yang F., MAPK4 promotes prostate cancer by concerted activation of androgen receptor and AKT, J Clin Invest. 2021 Feb 15;131(4):e135465. doi: 10.1172/JCI135465.
Satpathy S, Jaehnig EJ, Krug K, Kim BJ, Saltzman AB, Chan DW, Holloway KR, Anurag M, Huang C, Singh P, Gao A, Namai N, Dou Y, Wen B, Vasaikar SV, Mutch D, Watson MA, Ma C, Ademuyiwa FO, Rimawi MF, Schiff R, Hoog J, Jacobs S, Malovannaya A, Hyslop T, Clauser KR, Mani DR, Perou CM, Miles G, Zhang B, Gillette MA, Carr SA, Ellis MJ., Microscaled proteogenomic methods for precision oncology, Nat Commun. 2020 Jan 27;11(1):532. doi: 10.1038/s41467-020-14381-2.
van de Ven, A. L., Abdollahi, B., Martinez, C. J., Burey, L. A., Landis, M. D., Chang, J. C., . . . Frieboes, H. B. (2013)., Modeling of nanotherapeutics delivery based on tumor perfusion., New Journal of Physics, 15, 55004. doi:10.1088/1367-2630/15/5/055004 [doi]
van Brussel, A. S., Adams, A., Vermeulen, J. F., Oliveira, S., van der Wall, E., Mali, W. P., . . . van Bergen En Henegouwen, P. M. (2013), Molecular imaging with a fluorescent antibody targeting carbonic anhydrase IX can successfully detect hypoxic ductal carcinoma in situ of the breast., Breast Cancer Research and Treatment, 140(2), 263-272. doi:10.1007/s10549-013-2635-6 [doi]
Huang D, Chowdhury S, Wang H, Savage SR, Ivey RG, Kennedy JJ, Whiteaker JR, Lin C, Hou X, Oberg AL, Larson MC, Eskandari N, Delisi DA, Gentile S, Huntoon CJ, Voytovich UJ, Shire ZJ, Yu Q, Gygi SP, Hoofnagle AN, Herbert ZT, Lorentzen TD, Calinawan A, Karnitz LM, Weroha SJ, Kaufmann SH, Zhang B, Wang P, Birrer MJ, Paulovich AG., Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer, Cell Rep Med. 2021 Dec 21;2(12):100471. doi: 10.1016/j.xcrm.2021.100471. eCollection 2021 Dec 21.
Fukumura K, Malgulwar PB, Fischer GM, Hu X, Mao X, Song X, Hernandez SD, Zhang XH, Zhang J, Parra ER, Yu D, Debeb BG, Davies MA, Huse JT., Multi-omic molecular profiling reveals potentially targetable abnormalities shared across multiple histologies of brain metastasis, Acta Neuropathol. 2021 Feb;141(2):303-321. doi: 10.1007/s00401-020-02256-1. Epub 2021 Jan 4.
Vermeulen, J. F., van Brussel, A. S., Adams, A., Mali, W. P., van der Wall, E., van Diest, P. J., & Derksen, P. W. (2013)., Near-infrared fluorescence molecular imaging of ductal carcinoma in situ with CD44v6-specific antibodies in mice: A preclinical study., Molecular Imaging and Biology : MIB : The Official Publication of the Academy of Molecular Imaging, 15(3), 290-298. doi:10.1007/s11307-012-0605-8 [doi]
Veeraraghavan J, Gutierrez C, Sethunath V, Mehravaran S, Giuliano M, Shea MJ, Mitchell T, Wang T, Nanda S, Pereira R, Davis R, Goutsouliak K, Qin L, De Angelis C, Diala I, Lalani AS, Nagi C, Hilsenbeck SG, Rimawi MF, Osborne CK, Schiff R., Neratinib plus trastuzumab is superior to pertuzumab plus trastuzumab in HER2-positive breast cancer xenograft models, NPJ Breast Cancer. 2021 May 27;7(1):63. doi: 10.1038/s41523-021-00274-0.
Zheng ZY, Anurag M, Lei JT, Cao J, Singh P, Peng J, Kennedy H, Nguyen NC, Chen Y, Lavere P, Li J, Du XH, Cakar B, Song W, Kim BJ, Shi J, Seker S, Chan DW, Zhao GQ, Chen X, Banks KC, Lanman RB, Shafaee MN, Zhang XH, Vasaikar S, Zhang B, Hilsenbeck SG, Li W, Foulds CE, Ellis MJ, Chang EC., Neurofibromin Is an Estrogen Receptor-Îą Transcriptional Co-repressor in Breast Cancer, Cancer Cell. 2020 Mar 16;37(3):387-402.e7. doi: 10.1016/j.ccell.2020.02.003. Epub 2020 Mar 5.
Abelson, S., Shamai, Y., Berger, L., Skorecki, K., & Tzukerman, M. (2013)., Niche-dependent gene expression profile of intratumoral heterogeneous ovarian cancer stem cell populations., PloS One, 8(12), e83651. doi:10.1371/journal.pone.0083651 [doi]
Katz, E., Skorecki, K., & Tzukerman, M. (2009), Niche-dependent tumorigenic capacity of malignant ovarian ascites-derived cancer cell subpopulations, Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 15(1), 70-80. doi:10.1158/1078-0432.CCR-08-1233 [doi]
Sundararajan V, Tan TZ, Lim D, Peng Y, Wengner AM, Ngoi NYL, Jeyasekharan AD, Tan DSP., Nuclear pCHK1 as a potential biomarker of increased sensitivity to ATR inhibition, J Pathol. 2023 Feb;259(2):194-204. doi: 10.1002/path.6032. Epub 2022 Dec 8.
Sundararajan V, Tan TZ, Lim D, Peng Y, Wengner AM, Ngoi NYL, Jeyasekharan AD, Tan DSP., Nuclear pCHK1 as a potential biomarker of increased sensitivity to ATR inhibition., J Pathol. 2023 Feb;259(2):194-204. doi: 10.1002/path.6032. Epub 2022 Dec 8.
Torres, Diogo; Hou, Xiaonan; Bale, Laurie; Heinzen, Ethan P; Maurer, Matthew J; Zanfagnin, Valentina; Oberg, Ann L; Conover, Cheryl; Weroha, S John, Overcoming platinum resistance in ovarian cancer by targeting pregnancy-associated plasma protein-A, PloS one Vol.14, 2019
Sheng Q, D'Alessio JA, Menezes DL, Karim C, Tang Y, Tam A, Clark S, Ying C, Connor A, Mansfield KG, Rondeau JM, Ghoddusi M, Geyer FC, Gu J, McLaughlin ME, Newcombe R, Elliot G, Tschantz WR, Lehmann S, Fanton CP, Miller K, Huber T, Rendahl KG, Jeffry U, Pryer NK, Lees E, Kwon P, Abraham JA, Damiano JS, Abrams TJ., PCA062, a P-cadherin Targeting Antibody-Drug Conjugate, Displays Potent Antitumor Activity Against P-cadherin-expressing Malignancies, Mol Cancer Ther. 2021 Jul;20(7):1270-1282. doi: 10.1158/1535-7163.MCT-20-0708. Epub 2021 Apr 20.
Sasikumar PG, Sudarshan NS, Adurthi S, Ramachandra RK, Samiulla DS, Lakshminarasimhan A, Ramanathan A, Chandrasekhar T, Dhudashiya AA, Talapati SR, Gowda N, Palakolanu S, Mani J, Srinivasrao B, Joseph D, Kumar N, Nair R, Atreya HS, Gowda N, Ramachandra M., PD-1 derived CA-170 is an oral immune checkpoint inhibitor that exhibits preclinical anti-tumor efficacy, Commun Biol. 2021 Jun 8;4(1):699. doi: 10.1038/s42003-021-02191-1.
Ronca R, Taranto S, Corsini M, Tobia C, Ravelli C, Rezzola S, Belleri M, De Cillis F, Cattaneo A, Presta M, Giacomini A., Pentraxin 3 Inhibits the Angiogenic Potential of Multiple Myeloma Cells, Cancers (Basel). 2021 May 8;13(9):2255. doi: 10.3390/cancers13092255.
Reka, A. K., Kurapati, H., Narala, V. R., Bommer, G., Chen, J., Standiford, T. J., & Keshamouni, V. G. (2010)., Peroxisome proliferator-activated receptor-gamma activation inhibits tumor metastasis by antagonizing Smad3-mediated epithelial-mesenchymal transition., Molecular Cancer Therapeutics, 9(12), 3221-3232. doi:10.1158/1535-7163.MCT-10-0570 [doi]
Hong, S. H., Youbi, S. E., Hong, S. P., Kallakury, B., Monroe, P., Erkizan, H. V., . . . Toretsky, J. A. (2014)., Pharmacokinetic modeling optimizes inhibition of the 'undruggable' EWS-FLI1 transcription factor in ewing sarcoma, Oncotarget, 5(2), 338-350. doi:1495 [pii]
Davila-Gonzalez, D., Choi, D. S., Rosato, R. R., Granados-Principal, S. M., Kuhn, J. G., Li, W. F., . . . Chang, J. C. (2018)., Pharmacological inhibition of NOS activates ASK1/JNK pathway augmenting docetaxel-mediated apoptosis in triple-negative breast cancer., Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 24(5), 1152-1162. doi:10.1158/1078-0432.CCR-17-1437 [doi]
Zhao, N., Cao, J., Xu, L., Tang, Q., Dobrolecki, L. E., Lv, X., . . . Chen, X. (2018), Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer., The Journal of Clinical Investigation, 128(4), 1283-1299. doi:10.1172/JCI95873 [doi]
Colon-Otero G, Zanfagnin V, Hou X, Foster NR, Asmus EJ, Wahner Hendrickson A, Jatoi A, Block MS, Langstraat CL, Glaser GE, Dinh TA, Robertson MW, Camoriano JK, Butler KA, Copland JA, Weroha SJ., Phase II trial of ribociclib and letrozole in patients with relapsed oestrogen receptor-positive ovarian or endometrial cancers, ESMO Open. 2020 Oct;5(5):e000926. doi: 10.1136/esmoopen-2020-000926.
Santiago-O'Farrill JM, Weroha SJ, Hou X, Oberg AL, Heinzen EP, Maurer MJ, Pang L, Rask P, Amaravadi RK, Becker SE, Romero I, Rubio MJ, Matias-Guiu X, Santacana M, Llombart-Cussac A, Poveda A, Lu Z, Bast RC Jr., Poly(adenosine diphosphate ribose) polymerase inhibitors induce autophagy-mediated drug resistance in ovarian cancer cells, xenografts, and patient-derived xenograft models, Cancer. 2020 Feb 15;126(4):894-907. doi: 10.1002/cncr.32600. Epub 2019 Nov 12.
Ingallina, C., Costa, P. M., Ghirga, F., Klippstein, R., Wang, J. T., Berardozzi, S., . . . Al-Jamal, K. T. (2017)., Polymeric glabrescione B nanocapsules for passive targeting of hedgehog-dependent tumor therapy in vitro., Nanomedicine (London, England), 12(7), 711-728. doi:10.2217/nnm-2016-0388 [doi]
Schott, A. F., Landis, M. D., Dontu, G., Griffith, K. A., Layman, R. M., Krop, I., . . . Chang, J. C. (2013), Preclinical and clinical studies of gamma secretase inhibitors with docetaxel on human breast tumors, Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 19(6), 1512-1524. doi:10.1158/1078-0432.CCR-11-3326 [doi]
Abrams, T., Connor, A., Fanton, C., Cohen, S. B., Huber, T., Miller, K., . . . Schleyer, S. C. (2018), Preclinical antitumor activity of a novel anti-c-KIT antibody-drug conjugate against mutant and wild-type c-KIT-positive solid tumors, Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 24(17), 4297-4308. doi:10.1158/1078-0432.CCR-17-3795 [doi]
Janku F, Han SW, Doi T, Amatu A, Ajani JA, Kuboki Y, Cortez A, Cellitti SE, Mahling PC, Subramanian K, Schoenfeld HA, Choi SM, Iaconis LA, Lee LH, Pelletier MR, Dranoff G, Askoxylakis V, Siena S., Preclinical Characterization and Phase I Study of an Anti-HER2-TLR7 Immune-Stimulator Antibody Conjugate in Patients with HER2+ Malignancies, Cancer Immunol Res. 2022 Dec 2;10(12):1441-1461. doi: 10.1158/2326-6066.CIR-21-0722.
Lee, F. Y., Smykla, R., Johnston, K., Menard, K., McGlinchey, K., Peterson, R. W., . . . Kramer, R. (2009, Preclinical efficacy spectrum and pharmacokinetics of ixabepilone, Cancer Chemotherapy and Pharmacology, 63(2), 201-212. doi:10.1007/s00280-008-0727-5 [doi]
Kim BJ, Zheng ZY, Lei JT, Holt MV, Chen A, Peng J, Fandino D, Singh P, Kennedy H, Dou Y, Chica-Parrado MDR, Bikorimana E, Ye D, Wang Y, Hanker AB, Mohamed N, Hilsenbeck SG, Lim B, Asirvatham JR, Sreekumar A, Zhang B, Miles G, et al., Proteogenomic Approaches for the Identification of NF1/Neurofibromin-depleted Estrogen Receptor-positive Breast Cancers for Targeted Treatment., Cancer Res Commun. 2023 Jul 26;3(7):1366-1377. doi: 10.1158/2767-9764.CRC-23-0044. eCollection 2023 Jul.
Huang, K. L., Li, S., Mertins, P., Cao, S., Gunawardena, H. P., Ruggles, K. V., . . . Ding, L. (2017)., Proteogenomic integration reveals therapeutic targets in breast cancer xenografts, Nature Communications, 8, 14864. doi:10.1038/ncomms14864 [doi]
Goswami, M. T., Reka, A. K., Kurapati, H., Kaza, V., Chen, J., Standiford, T. J., & Keshamouni, V. G. (2015), Regulation of complement-dependent cytotoxicity by TGF-beta-induced epithelial-mesenchymal transition., Oncogene, doi:10.1038/onc.2015.258 [doi]
McDaid, William J; Greene, Michelle K; Johnston, Michael C; Pollheimer, Ellen; Smyth, Peter; McLaughlin, Kirsty; Van Schaeybroeck, Sandra; Straubinger, Robert M; Longley, Daniel B; Scott, Christopher J;, Repurposing of Cetuximab in antibody-directed chemotherapy-loaded nanoparticles in EGFR therapy-resistant pancreatic tumours, Nanoscale Vol.11, 2019
Speyer, C. L., Bukhsh, M. A., Jafry, W. S., Sexton, R. E., Bandyopadhyay, S., & Gorski, D. H. (2017)., Riluzole synergizes with paclitaxel to inhibit cell growth and induce apoptosis in triple-negative breast cancer., Breast Cancer Research and Treatment, 166(2), 407-419. doi:10.1007/s10549-017-4435-x [doi]
Miron, T., Wilchek, M., Shvidel, L., Berrebi, A., & Arditti, F. D. (2012)., S-allyl derivatives of 6-mercaptopurine are highly potent drugs against human B-CLL through synergism between 6-mercaptopurine and allicin., Leukemia Research, 36(12), 1536-1540. doi:10.1016/j.leukres.2012.08.023 [doi]
Rzymski, T., Mikula, M., Zylkiewicz, E., Dreas, A., Wiklik, K., Golas, A., . . . Brzozka, K. (2017)., SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains., Oncotarget, 8(20), 33779-33795. doi:10.18632/oncotarget.16810 [doi]
Catalano A, Adlesic M, Kaltenbacher T, Klar RFU, Albers J, Seidel P, Brandt LP, Hejhal T, Busenhart P, Röhner N, Zodel K, Fritsch K, Wild PJ, Duyster J, Fritsch R, Brummer T, Frew IJ., Sensitivity and Resistance of Oncogenic RAS-Driven Tumors to Dual MEK and ERK Inhibition, Cancers (Basel). 2021 Apr 13;13(8):1852. doi: 10.3390/cancers13081852.
Reddy TP, Choi DS, Anselme AC, Qian W, Chen W, Lantto J, Horak ID, Kragh M, Chang JC, Rosato RR., Simultaneous targeting of HER family pro-survival signaling with Pan-HER antibody mixture is highly effective in TNBC: a preclinical trial with PDXs, Breast Cancer Res. 2020 May 15;22(1):48. doi: 10.1186/s13058-020-01280-z.
Schenk MW, Humphrey S, Hossain ASMM, Revill M, Pearsall S, Lallo A, Brown S, Bratt S, Galvin M, Descamps T, Zhou C, Pearce SP, Priest L, Greenhalgh M, Chaturvedi A, Kerr A, Blackhall F, Dive C, Frese KK., Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer, Nat Commun. 2021 Nov 17;12(1):6652. doi: 10.1038/s41467-021-26823-6.
Li, X., Wu, J. B., Li, Q., Shigemura, K., Chung, L. W., & Huang, W. C. (2016)., SREBP-2 promotes stem cell-like properties and metastasis by transcriptional activation of c-myc in prostate cancer, Lee, F. Y., Smykla, R., Johnston, K., Menard, K., McGlinchey, K., Peterson, R. W., . . . Kramer, R. (2009
Egberts, J. H., Schniewind, B., Sipos, B., Hinz, S., Kalthoff, H., & Tepel, J. (2007)., Superiority of extended neoadjuvant chemotherapy with gemcitabine in pancreatic cancer: A comparative analysis in a clinically adapted orthotopic xenotransplantation model in SCID beige mice., Cancer Biology & Therapy, 6(8), 1227-1232. doi:4414 [pii]
Vallejo-Diaz, J., Olazabal-Moran, M., Cariaga-Martinez, A. E., Pajares, M. J., Flores, J. M., Pio, R., . . . Carrera, A. C. (2016), Targeted depletion of PIK3R2 induces regression of lung squamous cell carcinoma., Oncotarget, 7(51), 85063-85078. doi:10.18632/oncotarget.13195 [doi]
Schwarzer A, Oliveira M, Kleppa MJ, Slattery SD, Anantha A, Cooper A, Hannink M, Schambach A, Dörrie A, Kotlyarov A, Gaestel M, Hembrough T, Levine J, Luther M, Stocum M, Stiles L, Weinstock DM, Liesa M, Kostura MJ., Targeting Aggressive B-cell Lymphomas through Pharmacological Activation of the Mitochondrial Protease OMA1., Mol Cancer Ther. 2023 Nov 1;22(11):1290-1303. doi: 10.1158/1535-7163.MCT-22-0718.
Harris, Faye R; Zhang, Piyan; Yang, Lin; Hou, Xiaonan; Leventakos, Konstantinos; Weroha, Saravut J; Vasmatzis, George; Kovtun, Irina V;, Targeting HER2 in patient-derived xenograft ovarian cancer models sensitizes tumors to chemotherapy., Molecular oncology Vol.13, 2019
Guerra-Rebollo, Marta; Garrido, Cristina; Sánchez-Cid, Lourdes; Soler-Botija, Carolina; Meca-Cortés, Oscar; Rubio, Nuria; Blanco, Jerónimo;, Targeting of replicating CD133 and OCT4/SOX2 expressing glioma stem cells selects a cell population that reinitiates tumors upon release of therapeutic pressure., Scientific reports Vol.9, 2019
Xu, W., Lacerda, L., Debeb, B. G., Atkinson, R. L., Solley, T. N., Li, L., . . . Woodward, W. A. (2013)., The antihelmintic drug pyrvinium pamoate targets aggressive breast cancer., PloS One, 8(8), e71508. doi:10.1371/journal.pone.0071508 [doi]
Bado IL, Zhang W, Hu J, Xu Z, Wang H, Sarkar P, Li L, Wan YW, Liu J, Wu W, Lo HC, Kim IS, Singh S, Janghorban M, Muscarella AM, Goldstein A, Singh P, Jeong HH, Liu C, Schiff R, Huang S, Ellis MJ, Gaber MW, Gugala Z, Liu Z, Zhang XH., The bone microenvironment increases phenotypic plasticity of ER(+) breast cancer cells, Dev Cell. 2021 Apr 19;56(8):1100-1117.e9. doi: 10.1016/j.devcel.2021.03.008.
Serebrenik AA, Argyris PP, Jarvis MC, Brown WL, Bazzaro M, Vogel RI, Erickson BK, Lee SH, Goergen KM, Maurer MJ, Heinzen EP, Oberg AL, Huang Y, Hou X, Weroha SJ, Kaufmann SH, Harris RS., The DNA Cytosine Deaminase APOBEC3B is a Molecular Determinant of Platinum Responsiveness in Clear Cell Ovarian Cancer, Clin Cancer Res. 2020 Jul 1;26(13):3397-3407. doi: 10.1158/1078-0432.CCR-19-2786. Epub 2020 Feb 14.
Kollmann, Karoline; Briand, Coralie; Bellutti, Florian; Schicher, Nikolaus; Blunder, Stefan; Zojer, Markus; Hoeller, Christoph;, The interplay of CDK4 and CDK6 in melanoma, Oncotarget Vol.10, 2019
Le Moigne, R., Aftab, B. T., Djakovic, S., Dhimolea, E., Valle, E., Murnane, M., . . . Rolfe, M. (2017), The p97 inhibitor CB-5083 is a unique disrupter of protein homeostasis in models of multiple myeloma., Molecular Cancer Therapeutics, 16(11), 2375-2386. doi:10.1158/1535-7163.MCT-17-0233 [doi]
Sukowati, C. H., Anfuso, B., Croce, L. S., & Tiribelli, C. (2015)., The role of multipotent cancer associated fibroblasts in hepatocarcinogenesi, BMC Cancer, 15, 188-015-1196-y. doi:10.1186/s12885-015-1196-y [doi]
Zhang, X. D., Baladandayuthapani, V., Lin, H., Mulligan, G., Li, B., Esseltine, D. W., . . . Orlowski, R. Z. (2016)., Tight junction protein 1 modulates proteasome capacity and proteasome inhibitor sensitivity in multiple myeloma via EGFR/JAK1/STAT3 signaling., Cancer Cell, 29(5), 639-652. doi:S1535-6108(16)30109-X [pii]
Kettler B, Trauzold A, Röder C, Egberts JH, Kalthoff H., Topology impacts TRAIL therapy: Differences in primary cancer growth and liver metastasis between orthotopic and subcutaneous xenotransplants of pancreatic ductal adenocarcinoma cells, Hepatobiliary Pancreat Dis Int. 2021 Jun;20(3):279-284. doi: 10.1016/j.hbpd.2021.04.005. Epub 2021 Apr 26.
Alkim E, Dowst H, DiCarlo J, Dobrolecki LE, Hernández-Herrera A, Hormuth DA 2nd, Liao Y, McOwiti A, Pautler R, Rimawi M, Roark A, Srinivasan RR, Virostko J, Zhang B, Zheng F, Rubin DL, Yankeelov TE, Lewis MT., Toward Practical Integration of Omic and Imaging Data in Co-Clinical Trials., Tomography. 2023 Apr 10;9(2):810-828. doi: 10.3390/tomography9020066.
Chang G, Shi L, Ye Y, Shi H, Zeng L, Tiwary S, Huse JT, Huo L, Ma L, Ma Y, Zhang S, Zhu J, Xie V, Li P, Han L, He C, Huang S., YTHDF3 Induces the Translation of m(6)A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis, Cancer Cell. 2020 Dec 14;38(6):857-871.e7. doi: 10.1016/j.ccell.2020.10.004. Epub 2020 Oct 29.
Kanakkanthara, Arun; Huntoon, Catherine J; Hou, Xiaonan; Zhang, Minzhi; Heinzen, Ethan P; OBrien, Daniel R; Oberg, Ann L; John Weroha, S; Kaufmann, Scott H; Karnitz, Larry M;, ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer., Nature communications Vol.10, 2019

Other

Hu X, Villodre ES, Larson R, Rahal OM, Wang X, Gong Y, Song J, Krishnamurthy S, Ueno NT, Tripathy D, Woodward WA, Debeb BG., Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer, Commun Biol. 2021 Jan 15;4(1):72. doi: 10.1038/s42003-020-01590-0.
Gabay M, Weizman A, Zeineh N, Kahana M, Obeid F, Allon N, Gavish M., Liposomal Carrier Conjugated to APP-Derived Peptide for Brain Cancer Treatment, Cell Mol Neurobiol. 2021 Jul;41(5):1019-1029. doi: 10.1007/s10571-020-00969-1. Epub 2020 Oct 6.
Smith DL, Debeb BG, Diagaradjane P, Larson R, Kumar S, Ning J, Lacerda L, Li L, Woodward WA., Prophylactic cranial irradiation reduces the incidence of brain metastasis in a mouse model of metastatic, HER2-positive breast cancer, Genes Cancer. 2021 Mar 13;12:28-38. doi: 10.18632/genesandcancer.212. eCollection 2021.
Catalano A, Adlesic M, Kaltenbacher T, Klar RFU, Albers J, Seidel P, Brandt LP, Hejhal T, Busenhart P, Röhner N, Zodel K, Fritsch K, Wild PJ, Duyster J, Fritsch R, Brummer T, Frew IJ., Sensitivity and Resistance of Oncogenic RAS-Driven Tumors to Dual MEK and ERK Inhibition, Cancers (Basel). 2021 Apr 13;13(8):1852. doi: 10.3390/cancers13081852.
Iizuka S, Quintavalle M, Navarro JC, Gribbin KP, Ardecky RJ, Abelman MM, Ma CT, Sergienko E, Zeng FY, Pass I, Thomas GV, McWeeney SK, Hassig CA, Pinkerton AB, Courtneidge SA., Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5? Promotes Cancer Invasion and Tumor Growth, Cancer Res. 2021 Mar 15;81(6):1472-1485. doi: 10.1158/0008-5472.CAN-20-2383. Epub 2021 Jan 7.
Bernad R, Lynch CJ, Urdinguio RG, Stephan-Otto Attolini C, Fraga MF, Serrano M., Stability of Imprinting and Differentiation Capacity in Naďve Human Cells Induced by Chemical Inhibition of CDK8 and CDK19, Cells. 2021 Apr 12;10(4):876. doi: 10.3390/cells10040876.
Bado IL, Zhang W, Hu J, Xu Z, Wang H, Sarkar P, Li L, Wan YW, Liu J, Wu W, Lo HC, Kim IS, Singh S, Janghorban M, Muscarella AM, Goldstein A, Singh P, Jeong HH, Liu C, Schiff R, Huang S, Ellis MJ, Gaber MW, Gugala Z, Liu Z, Zhang XH., The bone microenvironment increases phenotypic plasticity of ER(+) breast cancer cells, Dev Cell. 2021 Apr 19;56(8):1100-1117.e9. doi: 10.1016/j.devcel.2021.03.008.

Transplantation

Fodor, A., Harel, C., Fodor, L., Armoni, M., Salmon, P., Trono, D., & Karnieli, E. (2007), Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: An ex vivo gene therapy approach., Diabetologia, 50(1), 121-130. doi:10.1007/s00125-006-0509-8 [doi]
Boehle, A. S., Dohrmann, P., Leuschner, I., Kalthoff, H., & Henne-Bruns, D. (2000), An improved orthotopic xenotransplant procedure for human lung cancer in SCID bg mice., The Annals of Thoracic Surgery, 69(4), 1010-1015. doi:S0003-4975(00)01090-0 [pii]
Keren A, Reich K, Bertolini M, Moga A, Riethmüller C, Ullmann Y, Paus R, Gilhar A., Autologous Th2-polarized lymphocytes induce atopic dermatitis lesions in non-atopic human skin xenotransplants., Allergy. 2023 Jun;78(6):1538-1553. doi: 10.1111/all.15635. Epub 2023 Mar 25.
LaMarca, H. L., Visbal, A. P., Creighton, C. J., Liu, H., Zhang, Y., Behbod, F., & Rosen, J. M. (2010)., CCAAT/enhancer binding protein beta regulates stem cell activity and specifies luminal cell fate in the mammary gland, Stem Cells (Dayton, Ohio), 28(3), 535-544. doi:10.1002/stem.297 [doi]
van der Veen EL, Suurs FV, Cleeren F, Bormans G, Elsinga PH, Hospers GAP, Lub-de Hooge MN, de Vries EGE, de Vries EFJ, Antunes IF., Development and Evaluation of Interleukin-2-Derived Radiotracers for PET Imaging of T Cells in Mice, J Nucl Med. 2020 Sep;61(9):1355-1360. doi: 10.2967/jnumed.119.238782. Epub 2020 Feb 28.
Monkkonen, T., Landua, J. D., Visbal, A. P., & Lewis, M. T. (2017)., Epithelial and non-epithelial Ptch1 play opposing roles to regulate proliferation and morphogenesis of the mouse mammary gland, Development (Cambridge, England), 144(7), 1317-1327. doi:10.1242/dev.140434 [doi]
Serafini, M., Sacchetti, B., Pievani, A., Redaelli, D., Remoli, C., Biondi, A., . . . Bianco, P. (2014)., Establishment of bone marrow and hematopoietic niches in vivo by reversion of chondrocyte differentiation of human bone marrow stromal cells., Stem Cell Research, 12(3), 659-672. doi:10.1016/j.scr.2014.01.006 [doi]
Goncalves, A. F., Adlesic, M., Brandt, S., Hejhal, T., Harlander, S., Sommer, L., . . . Frew, I. J. (2017)., Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells, Nature Communications, 8(1), 1466-017-01514-3. doi:10.1038/s41467-017-01514-3 [doi]
Park, J. H., Vithayathil, S., Kumar, S., Sung, P. L., Dobrolecki, L. E., Putluri, V., . . . Kaipparettu, B. A. (2016), Fatty acid oxidation-driven src links mitochondrial energy reprogramming and oncogenic properties in triple-negative breast cancer, Cell Reports, 14(9), 2154-2165. doi:S2211-1247(16)30071-7 [pii]
Delgado, E., Boisen, M. M., Laskey, R., Chen, R., Song, C., Sallit, J., . . . Oesterreich, S. (2016)., High expression of orphan nuclear receptor NR4A1 in a subset of ovarian tumors with worse outcome, Gynecologic Oncology, 141(2), 348-356. doi:S0090-8258(16)30054-3 [pii]
Keren A, Bertolini M, Keren Y, Ullmann Y, Paus R, Gilhar A., Human organ rejuvenation by VEGF-A: Lessons from the skin, Sci Adv. 2022 Jun 24;8(25):eabm6756. doi: 10.1126/sciadv.abm6756. Epub 2022 Jun 24.
Laufer Britva R, Keren A, Bertolini M, Ullmann Y, Paus R, Gilhar A., Involvement of ILC1-like innate lymphocytes in human autoimmunity, lessons from alopecia areata., Elife. 2023 Mar 17;12. pii: e80768. doi: 10.7554/eLife.80768.
Mischek, D., Steinborn, R., Petznek, H., Bichler, C., Zatloukal, K., Sturzl, M., . . . Hohenadl, C. (2009)., Molecularly characterised xenograft tumour mouse models: Valuable tools for evaluation of new therapeutic strategies for secondary liver cancers, Journal of Biomedicine & Biotechnology, 2009, 437284. doi:10.1155/2009/437284 [doi]
Abu-Tayeh, H., Weidenfeld, K., Zhilin-Roth, A., Schif-Zuck, S., Thaler, S., Cotarelo, C., . . . Barkan, D. (2016)., 'Normalizing' the malignant phenotype of luminal breast cancer cells via alpha(v)beta(3)-integrin., Cell Death & Disease, 7(12), e2491. doi:10.1038/cddis.2016.387 [doi]
Brandt, L. P., Albers, J., Hejhal, T., Catalano, A., Wild, P. J., & Frew, I. J. (2017)., Oncogenic HrasG12V expression plus knockdown of Cdkn2a using ecotropic lentiviral vectors induces high-grade endometrial stromal sarcoma., PloS One, 12(10), e0186102. doi:10.1371/journal.pone.0186102 [doi]
Kijanka, M. M., van Brussel, A. S., van der Wall, E., Mali, W. P., van Diest, P. J., van Bergen En Henegouwen, P. M., & Oliveira, S. (2016)., Optical imaging of pre-invasive breast cancer with a combination of VHHs targeting CAIX and HER2 increases contrast and facilitates tumour characterization., EJNMMI Research, 6(1), 14-016-0166-y. Epub 2016 Feb 10. doi:10.1186/s13550-016-0166-y [doi]
Gates, L. A., Gu, G., Chen, Y., Rohira, A. D., Lei, J. T., Hamilton, R. A., . . . Foulds, C. E. (2018)., Proteomic profiling identifies key coactivators utilized by mutant ERalpha proteins as potential new therapeutic targets., Oncogene, 37(33), 4581-4598. doi:10.1038/s41388-018-0284-2 [doi]
Sneddon, J. B., Borowiak, M., & Melton, D. A. (2012), Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchym, Nature, 491(7426), 765-768. doi:10.1038/nature11463 [doi]
Vesci, L., Carollo, V., Roscilli, G., Aurisicchio, L., Ferrara, F. F., Spagnoli, L., & De Santis, R. (2015)., Trastuzumab and docetaxel in a preclinical organotypic breast cancer model using tissue slices from mammary fat pad: Translational relevance., Oncology Reports, 34(3), 1146-1152. doi:10.3892/or.2015.4074 [doi]
Morrow, C. J., Trapani, F., Metcalf, R. L., Bertolini, G., Hodgkinson, C. L., Khandelwal, G., . . . Dive, C. (2016)., Tumourigenic non-small-cell lung cancer mesenchymal circulating tumour cells, A clinical case study. Annals of Oncology : Official Journal of the European Society for Medical Oncology, 27(6), 1155-1160. doi:10.1093/annonc/mdw122 [doi]
Davis, D. R., Zhang, Y., Smith, R. R., Cheng, K., Terrovitis, J., Malliaras, K., . . . Marban, E. (2009)., Validation of the cardiosphere method to culture cardiac progenitor cells from myocardial tissue, PloS One, 4(9), e7195. doi:10.1371/journal.pone.0007195 [doi]

Tumor cell growth

Alsamraae M, Costanzo-Garvey D, Teply BA, Boyle S, Sommerville G, Herbert ZT, Morrissey C, Dafferner AJ, Abdalla MY, Fallet RW, Kielian T, Jensen-Smith H, deOliveira EI, Chen K, Bettencourt IA, Wang JM, McVicar DW, Keeley T, Yu F, Cook LM., Androgen receptor inhibition suppresses anti-tumor neutrophil response against bone metastatic prostate cancer via regulation of TβRI expression., Cancer Lett. 2023 Nov 28;579:216468. doi: 10.1016/j.canlet.2023.216468. Epub 2023 Nov 7.
Tzukerman M, Shamai Y, Abramovich I, Gottlieb E, Selig S, Skorecki K., Comparative Analysis of the APOL1 Variants in the Genetic Landscape of Renal Carcinoma Cells, Cancers (Basel). 2022 Jan 30;14(3):733. doi: 10.3390/cancers14030733.
Han D, Wang W, Jeon JH, Shen T, Huang X, Yi P, Dong B, Yang F., Cooperative activation of PDK1 and AKT by MAPK4 enhances cancer growth and resistance to therapy., PLoS Biol. 2023 Aug 2;21(8):e3002227. doi: 10.1371/journal.pbio.3002227. eCollection 2023 Aug.
Kotzur R, Stein N, Kahlon S, Berhani O, Isaacson B, Mandelboim O., Eradication of CD48-positive tumors by selectively enhanced YTS cells harnessing the lncRNA NeST., iScience. 2023 Jul 5;26(8):107284. doi: 10.1016/j.isci.2023.107284. eCollection 2023 Aug 18.
Cotler MJ, Ramadi KB, Hou X, Christodoulopoulos E, Ahn S, Bashyam A, Ding H, Larson M, Oberg AL, Whittaker C, Jonas O, Kaufmann SH, Weroha SJ, Cima MJ., Machine-learning aided in situ drug sensitivity screening predicts treatment outcomes in ovarian PDX tumors, Transl Oncol. 2022 Jul;21:101427. doi: 10.1016/j.tranon.2022.101427. Epub 2022 Apr 26.
Wang W, Han D, Cai Q, Shen T, Dong B, Lewis MT, Wang R, Meng Y, Zhou W, Yi P, Creighton CJ, Moore DD, Yang F., MAPK4 promotes triple negative breast cancer growth and reduces tumor sensitivity to PI3K blockade, Nat Commun. 2022 Jan 11;13(1):245. doi: 10.1038/s41467-021-27921-1.
Villodre ES, Hu X, Eckhardt BL, Larson R, Huo L, Yoon EC, Gong Y, Song J, Liu S, Ueno NT, Krishnamurthy S, Pusch S, Tripathy D, Woodward WA, Debeb BG., NDRG1 in Aggressive Breast Cancer Progression and Brain Metastasis, J Natl Cancer Inst. 2022 Apr 11;114(4):579-591. doi: 10.1093/jnci/djab222.
Wang L, Paudel BB, McKnight RA, Janes KA., Nucleocytoplasmic transport of active HER2 causes fractional escape from the DCIS-like state., Nat Commun. 2023 Apr 13;14(1):2110. doi: 10.1038/s41467-023-37914-x.
Ogasawara A, Kiefer JR, Gill H, Chiang E, Sriraman S, Ferl GZ, Ziai J, Bohorquez SS, Guelman S, Wang X, Yang J, Phan MM, Nguyen V, Chung S, Yu C, Tinianow J, Waaijer SJH, De Crespigny A, Marik J, Boswell CA, Zabka T, Staflin K, Williams SP., Preclinical development of ZED8, an (89)Zr immuno-PET reagent for monitoring tumor CD8 status in patients undergoing cancer immunotherapy, Eur J Nucl Med Mol Imaging. 2023 Jan;50(2):287-301. doi: 10.1007/s00259-022-05968-6. Epub 2022 Oct 22.

Tumor growth

Ahmadian Baghbaderani, B., Tian, X., Scotty Cadet, J., Shah, K., Walde, A., Tran, H., . . . Fellner, T. (2016)., A newly defined and xeno-free culture medium supports every-other-day medium replacement in the generation and long-term cultivation of human pluripotent stem cells, PloS One, 11(9), e0161229. doi:10.1371/journal.pone.0161229 [doi]
Silberman, Alon; Goldman, Omer; Boukobza Assayag, Odeya; Jacob, Adi; Rabinovich, Shiran; Adler, Lital; Lee, Joo Sang; Keshet, Rom; Sarver, Alona; Frug, Julia; Stettner, Noa; Galai, Sivan; Persi, Erez; Halpern, Keren Bahar; Zaltsman-Amir, Yehudit; Pode-Shakked, Ben; Eilam, Raya; Anikster, Yair; Nagamani, Sandesh C S; Ulitsky, Igor; Ruppin, Eytan; Erez, Ayelet;, Acid-Induced Downregulation of ASS1 Contributes to the Maintenance of Intracellular pH in Cancer., Cancer research Vol.79, 2019
Andersen, C. L., Sikora, M. J., Boisen, M. M., Ma, T., Christie, A., Tseng, G., . . . Oesterreich, S. (2017)., Active estrogen receptor-alpha signaling in ovarian cancer models and clinical specimens, Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 23(14), 3802-3812. doi:10.1158/1078-0432.CCR-16-1501 [doi]
Rhodes, L. V., Muir, S. E., Elliott, S., Guillot, L. M., Antoon, J. W., Penfornis, P., . . . Burow, M. E. (2010)., Adult human mesenchymal stem cells enhance breast tumorigenesis and promote hormone independence., Breast Cancer Research and Treatment, 121(2), 293-300. doi:10.1007/s10549-009-0458-2 [doi]
Urbinati, G., Ali, H. M., Rousseau, Q., Chapuis, H., Desmaele, D., Couvreur, P., & Massaad-Massade, L. (2015)., Antineoplastic effects of siRNA against TMPRSS2-ERG junction oncogene in prostate cancer., PloS One, 10(5), e0125277. doi:10.1371/journal.pone.0125277 [doi]
Farrera-Sal M, de Sostoa J, NuĂąez-ManchĂłn E, Moreno R, Fillat C, Bazan-Peregrino M, Alemany R., Arming Oncolytic Adenoviruses: Effect of Insertion Site and Splice Acceptor on Transgene Expression and Viral Fitness, Int J Mol Sci. 2020 Jul 21;21(14):5158. doi: 10.3390/ijms21145158.
Ramirez, Arturo B; Bhat, Raksha; Sahay, Debashish; De Angelis, Carmine; Thangavel, Hariprasad; Hedayatpour, Sina; Dobrolecki, Lacey E; Nardone, Agostina; Giuliano, Mario; Nagi, Chandandeep; Rimawi, Mothaffar; Osborne, C Kent; Lewis, Michael T; Stilwell, Jackie L; Kaldjian, Eric P; Schiff, Rachel; Trivedi, Meghana V;, Circulating tumor cell investigation in breast cancer patient-derived xenograft models by automated immunofluorescence staining, image acquisition, and single cell retrieval and analysis, BMC cancer Vol.19, 2019
Blum, B., & Benvenisty, N. (2007), Clonal analysis of human embryonic stem cell differentiation into teratomas., Stem Cells (Dayton, Ohio), 25(8), 1924-1930. doi:2007-0073 [pii]
De Thaye E, Van de Vijver K, Van der Meulen J, Taminau J, Wagemans G, Denys H, Van Dorpe J, Berx G, Ceelen W, Van Bocxlaer J, De Wever O., Establishment and characterization of a cell line and patient-derived xenograft (PDX) from peritoneal metastasis of low-grade serous ovarian carcinoma, Sci Rep. 2020 Apr 21;10(1):6688. doi: 10.1038/s41598-020-63738-6.
Schweppe RE, Pozdeyev N, Pike LA, Korch C, Zhou Q, Sams SB, Sharma V, Pugazhenthi U, Raeburn C, Albuja-Cruz MB, Reigan P, LaBarbera DV, Landa I, Knauf JA, Fagin JA, Haugen BR, Establishment and Characterization of Four Novel Thyroid Cancer Cell Lines and PDX Models Expressing the RET/PTC1 Rearrangement, BRAFV600E, or RASQ61R as Drivers. Mol, Mol Cancer Res. 2019 May;17(5):1036-1048
Liu, Yuanhang; Chanana, Pritha; Davila, Jaime I; Hou, Xiaonan; Zanfagnin, Valentina; McGehee, Cordelia D; Goode, Ellen L; Polley, Eric C; Haluska, Paul; Weroha, S John; Wang, Chen;, Gene expression differences between matched pairs of ovarian cancer patient tumors and patient-derived xenografts, Scientific reports Vol.9, 2019
Orian-Rousseau, V., Mink, S., Mengwasser, J., HogenEsch, H., Guo, F., Thies, W. G., . . . Ponta, H. (2005), Genes upregulated in a metastasizing human colon carcinoma cell line., International Journal of Cancer.Journal International Du Cancer, 113(5), 699-705. doi:10.1002/ijc.20644 [doi]
Kamarajugadda, S., Stemboroski, L., Cai, Q., Simpson, N. E., Nayak, S., Tan, M., & Lu, J. (2012)., Glucose oxidation modulates anoikis and tumor metastasis, Molecular and Cellular Biology, 32(10), 1893-1907. doi:10.1128/MCB.06248-11 [doi]
Nehil, M., Paquette, J., Tokuyasu, T., & McCormick, F. (2014)., High mobility group box 1 promotes tumor cell migration through epigenetic silencing of semaphorin 3A., . Oncogene, 33(44), 5151-5162. doi:10.1038/onc.2013.459 [doi]
Amendola, D., Nardella, M., Guglielmi, L., Cerquetti, L., Carico, E., Alesi, V., . . . Bucci, B. (2014)., Human placenta-derived neurospheres are susceptible to transformation after extensive in vitro expansion., Stem Cell Research & Therapy, 5(2), 55. doi:10.1186/scrt444 [doi]
Adler-Levy, Yael; Nardi-Schreiber, Atara; Harris, Talia; Shaul, David; Uppala, Sivaranjan; Sapir, Gal; Lev-Cohain, Naama; Sosna, Jacob; Goldberg, Shraga Nahum; Gomori, J Moshe; Katz-Brull, Rachel;, In-cell determination of Lactate Dehydrogenase Activity in a Luminal Breast Cancer Model ?? ex vivo Investigation of Excised Xenograft Tumor Slices Using dDNP Hyperpolarized [1-13C]pyruvate, Sensors (Basel, Switzerland) Vol.19, 2019
Abelson, S., Shamai, Y., Berger, L., Shouval, R., Skorecki, K., & Tzukerman, M. (2012)., Intratumoral heterogeneity in the self-renewal and tumorigenic differentiation of ovarian cancer, Stem Cells (Dayton, Ohio), 30(3), 415-424. doi:10.1002/stem.1029 [doi]
Debeb, B. G., Lacerda, L., Anfossi, S., Diagaradjane, P., Chu, K., Bambhroliya, A., . . . Woodward, W. A. (2016)., miR-141-mediated regulation of brain metastasis from breast cancer, Journal of the National Cancer Institute, 108(8), 10.1093/jnci/djw026. Print 2016 Aug. doi:10.1093/jnci/djw026 [doi]
Kanabur, P., Guo, S., Simonds, G. R., Kelly, D. F., Gourdie, R. G., Verbridge, S. S., & Sheng, Z. (2016)., Patient-derived glioblastoma stem cells respond differentially to targeted therapies., Oncotarget, 7(52), 86406-86419. doi:10.18632/oncotarget.13415 [doi]
Santiago-OFarrill, Janice M; Weroha, S John; Hou, Xiaonan; Oberg, Ann L; Heinzen, Ethan P; Maurer, Matthew J; Pang, Lan; Rask, Philip; Amaravadi, Ravi K; Becker, Sarah E; Romero, Ignacio; Rubio, Ma JesĂşs; Matias-Guiu, Xavier; Santacana, Maria; Llombart-Cussac, Antonio; Poveda, AndrĂŠs; Lu, Zhen; Bast, Robert C, Poly(adenosine diphosphate ribose) polymerase inhibitors induce autophagy-mediated drug resistance in ovarian cancer cells, xenografts, and patient-derived xenograft models. Cancer, Cancer Vol.14, 2019
Butler, K. A., Hou, X., Becker, M. A., Zanfagnin, V., Enderica-Gonzalez, S., Visscher, D., . . . Weroha, S. J. (2017)., Prevention of human lymphoproliferative tumor formation in ovarian cancer patient-derived xenografts., Neoplasia (New York, N.Y.), 19(8), 628-636. doi:S1476-5586(17)30079-9 [pii]
Yuzhalin, Arseniy E; Lim, Su Yin; Gordon-Weeks, Alex N; Fischer, Roman; Kessler, Benedikt M; Yu, Dihua; Muschel, Ruth J;, Proteomics analysis of the matrisome from MC38 experimental mouse liver metastases. American journal of physiology., Gastrointestinal and liver physiology Vol.317, 2019
Shamai, Yeela; Alperovich, Dalia Cohn; Yakhini, Zohar; Skorecki, Karl; Tzukerman, Maty;, Reciprocal Reprogramming of Cancer Cells and Associated Mesenchymal Stem Cells in Gastric Cancer, Stem cells (Dayton, Ohio) Vol.37, 2019
Wolfe, A. R., Debeb, B. G., Lacerda, L., Larson, R., Bambhroliya, A., Huang, X., . . . Woodward, W. A. (2015)., Simvastatin prevents triple-negative breast cancer metastasis in pre-clinical models through regulation of FOXO3a., Breast Cancer Research and Treatment, 154(3), 495-508. doi:10.1007/s10549-015-3645-3 [doi]
Capello, M., Ferri-Borgogno, S., Riganti, C., Chattaragada, M. S., Principe, M., Roux, C., . . . Novelli, F. (2016)., Targeting the warburg effect in cancer cells through ENO1 knockdown rescues oxidative phosphorylation and induces growth arrest., Oncotarget, 7(5), 5598-5612. doi:10.18632/oncotarget.6798 [doi]
Agu, C. A., Klein, R., Schwab, S., Konig-Schuster, M., Kodajova, P., Ausserlechner, M., . . . Hohenadl, C. (2006)., The cytotoxic activity of the bacteriophage lambda-holin protein reduces tumour growth rates in mammary cancer cell xenograft models, The Journal of Gene Medicine, 8(2), 229-241. doi:10.1002/jgm.833 [doi]
Elsner, L., Muppala, V., Gehrmann, M., Lozano, J., Malzahn, D., Bickeboller, H., . . . Dressel, R. (2007)., The heat shock protein HSP70 promotes mouse NK cell activity against tumors that express inducible NKG2D ligands., Journal of Immunology (Baltimore, Md.: 1950), 179(8), 5523-5533. doi:179/8/5523 [pii]
Tzukerman, M., Rosenberg, T., Reiter, I., Ben-Eliezer, S., Denkberg, G., Coleman, R., . . . Skorecki, K. (2006), The influence of a human embryonic stem cell-derived microenvironment on targeting of human solid tumor xenografts., Cancer Research, 66(7), 3792-3801. doi:66/7/3792 [pii]
Blouw, B., Patel, M., Iizuka, S., Abdullah, C., You, W. K., Huang, X., . . . Courtneidge, S. A. (2015)., The invadopodia scaffold protein Tks5 is required for the growth of human breast cancer cells in vitro and in vivo., PloS One, 10(3), e0121003. doi:10.1371/journal.pone.0121003 [doi]
Berger, L., Shamai, Y., Skorecki, K. L., & Tzukerman, M. (2016)., Tumor specific recruitment and reprogramming of mesenchymal stem cells in tumorigenesis., Stem Cells (Dayton, Ohio), 34(4), 1011-1026. doi:10.1002/stem.2269 [doi]
Kim, S. E., Zhang, L., Ma, K., Riegman, M., Chen, F., Ingold, I., . . . Overholtzer, M. (2016), Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth, ature Nanotechnology, 11(11), 977-985. doi:10.1038/nnano.2016.164 [doi]
Sharma S, Wu SY, Jimenez H, Xing F, Zhu D, Liu Y, Wu K, Tyagi A, Zhao D, Lo HW, Metheny-Barlow L, Sun P, Bourland JD, Chan MD, Thomas A, Barbault A, D'Agostino RB, Whitlow CT, Kirchner V, Blackman C, Pasche B,, Watabe K.Ca2+ and CACNA1H mediate targeted suppression of breast cancer brain metastasis by AM RF EMF, EBioMedicine. 2019 Jun; 44:194-208.

Subscribe to updates from Inotiv

Sign up and you’ll receive the latest updates that matter to you, delivered straight to your inbox.

Subscribe now