Pink1 knockout rats (Park6)
Related publications
Neuroscience
DeAngelo VM, Hilliard JD, McConnell GC., Dopaminergic but not cholinergic neurodegeneration is correlated with gait disturbances in PINK1 knockout rats., Behav Brain Res. 2022 Jan 24;417:113575. doi: 10.1016/j.bbr.2021.113575. Epub 2021 Sep 14.
Marquis JM, Lettenberger SE, Kelm-Nelson CA., Early-onset Parkinsonian behaviors in female Pink1-/- rats. Behav Brain Res. 2020 Jan 13;377:112175. doi: 10.1016/j.bbr.2019.112175. Epub 2019 Sep 19., Behavioural brain research Vol.332, 2017
Ferris CF, Morrison TR, Iriah S, Malmberg S, Kulkarni P, Hartner JC, Trivedi M., Evidence of Neurobiological Changes in the Presymptomatic PINK1 Knockout Rat. J Parkinsons Dis. 2018;8(2):281-301. doi: 10.3233/JPD-171273., Translational psychiatry Vol.5, 2015
Wu X, Li X, Liu Y, Yuan N, Li C, Kang Z, Zhang X, Xia Y, Hao Y, Tan Y., Hydrogen exerts neuroprotective effects on OGD/R damaged neurons in rat hippocampal by protecting mitochondrial function via regulating mitophagy mediated by PINK1/Parkin signaling pathway. Brain Res. 2018 Nov 1;1698:89-98. doi: 10.1016/j.brainres.2018.06.028. Epub 2018 Jun 27., Genes, brain, and behavior Vol.18, 2019
Creed RB, Goldberg MS., In search of early neuroradiological biomarkers for Parkinson's Disease: Alterations in resting state functional connectivity and gray matter microarchitecture in PINK1 -/- rats. Brain Res. 2019 Mar 1;1706:58-67. doi: 10.1016/j.brainres.2018.10.033. Epub 2018 Oct 31., Journal of neuroinflammation Vol.12, 2015
Creed RB, Roberts RC, Farmer CB, McMahon LL, Goldberg MS., Increased glutamate transmission onto dorsal striatum spiny projection neurons in Pink1 knockout rats, Neurobiol Dis. 2020 Dec 30;150:105246. doi: 10.1016/j.nbd.2020.105246. Online ahead of print.
Dagda RK, Dagda RY, Vazquez-Mayorga E, Martinez B, Gallahue A., Intranasal Administration of Forskolin and Noopept Reverses Parkinsonian Pathology in PINK1 Knockout Rats., Mol Metab. 2022;66:101631. doi:10.1016/j.molmet.2022.101631
Vazquez-Mayorga E, Grigoruta M, Dagda R, Martinez B, Dagda RK., Intraperitoneal Administration of Forskolin Reverses Motor Symptoms and Loss of Midbrain Dopamine Neurons in PINK1 Knockout Rats., J Parkinsons Dis. 2022;12(3):831-850. doi: 10.3233/JPD-213016.
Glass TJ, Kelm-Nelson CA, Russell JA, Szot JC, Lake JM, Connor NP, Ciucci MR., Laryngeal muscle biology in the Pink1-/- rat model of Parkinson disease. J Appl Physiol (1985). 2019 May 1;126(5):1326-1334. doi: 10.1152/japplphysiol.00557.2018. Epub 2019 Mar 7., Genes, brain, and behavior Vol.15, 2016
Orr AL, Rutaganira FU, de Roulet D, Huang EJ, Hertz NT, Shokat KM, Nakamura K., Long-term oral kinetin does not protect against Îą-synuclein-induced neurodegeneration in rodent models of Parkinson's disease. Neurochem Int. 2017 Oct;109:106-116. doi: 10.1016/j.neuint.2017.04.006. Epub 2017 Apr 20., Neuroscience letters Vol.544, 2013
Stauch KL, Villeneuve LM, Purnell PR, Ottemann BM, Emanuel K, Fox HS., Loss of Pink1 modulates synaptic mitochondrial bioenergetics in the rat striatum prior to motor symptoms: concomitant complex I respiratory defects and increased complex II-mediated respiration. Proteomics Clin Appl. 2016 Dec;10(12):1205-1217. doi: 10.1002/prca.201600005. Epub 2016 Sep 21., null
Hoffmeister JD, Kelm-Nelson CA, Ciucci MR., Manipulation of vocal communication and anxiety through pharmacologic modulation of norepinephrine in the Pink1-/- rat model of Parkinson disease, PLoS One. 2022;17(11):e0275937.
Nisbet AF, Lenell C, Glass T, Ciucci M., Neuromuscular Pathology of Extrinsic Tongue Muscles in the Pink1-/- Rat Model of Parkinson Disease, Behav Brain Res. 2022;424:113774. doi:10.1016/j.bbr.2022.113774
Cortese GP, Zhu M, Williams D, Heath S, Waites CL., Parkin Deficiency Reduces Hippocampal Glutamatergic Neurotransmission by Impairing AMPA Receptor Endocytosis. J Neurosci. 2016 Nov 30;36(48):12243-12258., Experimental neurology Vol.285, 2016
Sharma, A., Bazylianska, V., & Moszczynska, A., Parkin-deficient rats are resistant to neurotoxicity of chronic high-dose methamphetamine, Experimental Neurology 345 (2021): 113811.
Cullen KP, Grant LM, Kelm-Nelson CA, Brauer AFL, Bickelhaupt LB, Russell JA, Ciucci MR., Pink1 -/- Rats Show Early-Onset Swallowing Deficits and Correlative Brainstem Pathology. Dysphagia. 2018 Dec;33(6):749-758. doi: 10.1007/s00455-018-9896-5. Epub 2018 Apr 30., Pain Vol.160, 2019
Ren X, Hinchie A, Swomley A, Powell DK, Butterfield DA., Profiles of brain oxidative damage, ventricular alterations, and neurochemical metabolites in the striatum of PINK1 knockout rats as functions of age and gender: Relevance to Parkinson disease. Free Radic Biol Med. 2019 Nov 1;143:146-152. doi: 10.1016/j.freeradbiomed.2019.08.008. Epub 2019 Aug 8., Neuroscience Vol.284, 2015
Grigoruţă M, Martínez-Martínez A, Dagda RY, Dagda RK., Psychological Stress Phenocopies Brain Mitochondrial Dysfunction and Motor Deficits as Observed in a Parkinsonian Rat Model., Sleep Vol.41, 2018. Mol Neurobiol. 2020 Apr;57(4):1781-1798. doi: 10.1007/s12035-019-01838-9. Epub 2019 Dec 14.
Kelm-Nelson CA, Trevino MA, Ciucci MR., Quantitative Analysis of Catecholamines in the Pink1 -/- Rat Model of Early-onset Parkinson's Disease. Neuroscience. 2018 May 21;379:126-141. doi: 10.1016/j.neuroscience.2018.02.027. Epub 2018 Feb 27., European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology Vol.25, 2015
Pinizzotto CC, Dreyer KM, Aje OA, Caffrey RM, Madhira K, Kritzer MF., Spontaneous Object Exploration in a Recessive Gene Knockout Model of Parkinson's Disease: Development and Progression of Object Recognition Memory Deficits in Male Pink1-/- Rats, Genes Brain Behav. 2022;21(1):e12741. doi:10.1111/gbb.12741
Stauch KL, Villeneuve LM, Purnell PR, Pandey S, Guda C, Fox HS., SWATH-MS proteome profiling data comparison of DJ-1, Parkin, and PINK1 knockout rat striatal mitochondria. Data Brief. 2016 Sep 23;9:589-593. eCollection 2016 Dec., European archives of psychiatry and clinical neuroscience Vol.266, 2016
Barnett DGS, Lechner SA, Gammie SC, Kelm-Nelson CA., Thyroarytenoid Oxidative Metabolism and Synaptic Signaling Dysregulation in the Female Pink1-/- Rat, Laryngoscope. 2023 Dec;133(12):3412-3421. doi: 10.1002/lary.30768. Epub 2023 Jun 9.
Parkinson's disease
Stauch, K. L., Totusek, S., Farmer, T., Lamberty, B. G., Dyball, K. N., Almikhlafi, M. A., & Fox, H. S., Applying the RatWalker System for Gait Analysis in a Genetic Rat Model of Parkinson's Disease, JoVE (Journal of Visualized Experiments) 167 (2021): e62002.
Johnson RA, Kelm-Nelson CA, Ciucci MR., Changes to Ventilation, Vocalization, and Thermal Nociception in the Pink1-/- Rat Model of Parkinson's Disease, J Parkinsons Dis. 2020;10(2):489-504. doi: 10.3233/JPD-191853.
DeAngelo, V., Hilliard, J., McConnell, G., Dopaminergic but not cholinergic neurodegeneration is correlated with gait disturbances in PINK1 knockout rats, Behavioural Brain Research
Volume 417, 24 January 2022, 113575
Creed RB, Goldberg MS., Enhanced Susceptibility of PINK1 Knockout Rats to Îą-Synuclein Fibrils, Neuroscience. 2020 Jun 15;437:64-75. doi: 10.1016/j.neuroscience.2020.04.032. Epub 2020 Apr 27.
Glass TJ, Kelm-Nelson CA, Szot JC, Lake JM, Connor NP, Ciucci MR., Functional characterization of extrinsic tongue muscles in the Pink1-/- rat model of Parkinson disease, PLoS One. 2020 Oct 16;15(10):e0240366. doi: 10.1371/journal.pone.0240366. eCollection 2020.
Kelm-Nelson CA, Gammie S., Gene expression within the periaqueductal gray is linked to vocal behavior and early-onset parkinsonism in Pink1 knockout rats, BMC Genomics. 2020 Sep 17;21(1):625. doi: 10.1186/s12864-020-07037-4.
Lamberty, B. G., Estrella, L. D., Mattingly, J. E., Emanuel, K., Trease, A., Totusek, S., Sheldon, L., George, J. W., Almikhlafi, M. A., Farmer, T., & Stauch, K. L., Parkinson's disease relevant pathological features are manifested in male Pink1/Parkin deficient rats, Brain, behavior, & immunity - health, 31, 100656. https://doi.org/10.1016/j.bbih.2023.100656
Hoffmeister, J. D., Kelm-Nelson, C. A., & Ciucci, M. R., Quantification of brainstem norepinephrine relative to vocal impairment and anxiety in the Pink1-/- rat model of Parkinson disease, Behavioural Brain Research 414 (2021): 113514.
Lechner, S. A., Kletzien, H., Gammie, S. C., & Kelm?Nelson, C. A., Thyroarytenoid Muscle Gene Expression in a Rat Model of Early-Onset Parkinson's Disease, The Laryngoscope (2021).
Stress-induced neurological dysfunction
Grigoruţă M, Dagda RK, Díaz-Sánchez ÁG, Martínez-Martínez A., Psychological distress and lack of PINK1 promote bioenergetics alterations in peripheral blood mononuclear cells, Sci Rep. 2020 Jun 17;10(1):9820. doi: 10.1038/s41598-020-66745-9.
