CLOSE ×

General studies

Altshuler A, Amitai-Lange A, Tarazi N, Dey S, Strinkovsky L, Hadad-Porat S, Bhattacharya S, Nasser W, Imeri J, Ben-David G, Abboud-Jarrous G, Tiosano B, Berkowitz E, Karin N, Savir Y, Shalom-Feuerstein R., Discrete limbal epithelial stem cell populations mediate corneal homeostasis and wound healing, Cell Stem Cell. 2021 Jul 1;28(7):1248-1261.e8. doi: 10.1016/j.stem.2021.04.003. Epub 2021 May 12.

Immunology

Reuter, J. D., Fang, X., Ly, C. S., Suter, K. K., & Gibbs, D. (2012), Assessment of hazard risk associated with the intravenous use of viral vectors in rodents, Comparative Medicine, 62(5), 361-370.
Gunasekaran, K., Pentony, M., Shen, M., Garrett, L., Forte, C., Woodward, A., . . . Yan, W. (2010)., Enhancing antibody fc heterodimer formation through electrostatic steering effects: Applications to bispecific molecules and monovalent IgG, The Journal of Biological Chemistry, 285(25), 19637-19646. doi:10.1074/jbc.M110.117382 [doi]
Wooddell, C. I., Rozema, D. B., Hossbach, M., John, M., Hamilton, H. L., Chu, Q., . . . Lewis, D. L. (2013)., Hepatocyte-targeted RNAi therapeutics for the treatment of chronic hepatitis B virus infection., Molecular Therapy : The Journal of the American Society of Gene Therapy, 21(5), 973-985. doi:10.1038/mt.2013.31 [doi]
Precechtelova, J., Borsanyiova, M., Stipalova, D., Sarmirova, S., Gomolcak, P., Berakova, K., & Bopegamage, S. (2015)., Pathophysiology of the pancreas after oral infection of genetically diverse mice with coxsackievirus B4-E2, Archives of Virology, 160(1), 103-115. doi:10.1007/s00705-014-2236-7 [doi]
Oberst, M. D., Auge, C., Morris, C., Kentner, S., Mulgrew, K., McGlinchey, K., . . . Hammond, S. A. (2018)., Potent immune modulation by MEDI6383, an engineered human OX40 ligand IgG4P fc fusion protein., Molecular Cancer Therapeutics, 17(5), 1024-1038. doi:10.1158/1535-7163.MCT-17-0200 [doi]
Melis, M. H., Simpson, K. L., Dovedi, S. J., Welman, A., MacFarlane, M., Dive, C., . . . Illidge, T. M. (2013)., Sustained tumour eradication after induced caspase-3 activation and synchronous tumour apoptosis requires an intact host immune response, Cell Death and Differentiation, 20(5), 765-773. doi:10.1038/cdd.2013.8 [doi]
Lin, G. H. Y., Chai, V., Lee, V., Dodge, K., Truong, T., Wong, M., . . . Viller, N. N. (2017)., TTI-621 (SIRPalphaFc), a CD47-blocking cancer immunotherapeutic, triggers phagocytosis of lymphoma cells by multiple polarized macrophage subsets, PloS One, 12(10), e0187262. doi:10.1371/journal.pone.0187262 [doi]

Oncology

Van Impe, K., Bethuyne, J., Cool, S., Impens, F., Ruano-Gallego, D., De Wever, O., . . . Gettemans, J. (2013), A nanobody targeting the F-actin capping protein CapG restrains breast cancer metastasis., Breast Cancer Research : BCR, 15(6), R116. doi:10.1186/bcr3585 [doi]
Falah, Mizied; Rayan, Mahmoud; Rayan, Anwar, A Novel Paclitaxel Conjugate with Higher Efficiency and Lower Toxicity: A New Drug Candidate for Cancer Treatment., International journal of molecular sciences Vol.20, 2019
Grillo E, Corsini M, Ravelli C, di Somma M, Zammataro L, Monti E, Presta M, Mitola S., A novel variant of VEGFR2 identified by a pan-cancer screening of recurrent somatic mutations in the catalytic domain of tyrosine kinase receptors enhances tumor growth and metastasis, Cancer Lett. 2021 Jan 1;496:84-92. doi: 10.1016/j.canlet.2020.09.027. Epub 2020 Oct 6.
Hoogi, Shiran; Eisenberg, Vasyl; Mayer, Shimrit; Shamul, Astar; Barliya, Tilda; Cohen, Cyrille J, A TIGIT-based chimeric co-stimulatory switch receptor improves T-cell anti-tumor function, Journal for immunotherapy of cancer Vol.7, 2019
Jackson TR, Vuorinen A, Josa-Culleré L, Madden KS, Conole D, Cogswell TJ, Wilkinson IVL, Kettyle LM, Zhang D, O'Mahony A, Gracias D, McCall L, Westwood R, Terstappen GC, Davies SG, Tate EW, Wynne GM, Vyas P, Russell AJ, Milne TA., A tubulin binding molecule drives differentiation of acute myeloid leukemia cells, iScience. 2022 Jul 19;25(8):104787. doi: 10.1016/j.isci.2022.104787. eCollection 2022 Aug 19.
Zarrinkar, P. P., Gunawardane, R. N., Cramer, M. D., Gardner, M. F., Brigham, D., Belli, B., . . . Bhagwat, S. S. (2009), AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)., Blood, 114(14), 2984-2992. doi:10.1182/blood-2009-05-222034 [doi]
Bruckheimer, E. M., Fazenbaker, C. A., Gallagher, S., Mulgrew, K., Fuhrmann, S., Coffman, K. T., . . . Coats, S. (2009)., Antibody-dependent cell-mediated cytotoxicity effector-enhanced EphA2 agonist monoclonal antibody demonstrates potent activity against human tumors., Neoplasia (New York, N.Y.), 11(6), 509-17, 2 p following 517.
Yen, W. C., Fischer, M. M., Hynes, M., Wu, J., Kim, E., Beviglia, L., . . . Hoey, T. (2012), Anti-DLL4 has broad spectrum activity in pancreatic cancer dependent on targeting DLL4-notch signaling in both tumor and vasculature cells., Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 18(19), 5374-5386. doi:10.1158/1078-0432.CCR-12-0736 [doi]
Damelin, M., Bankovich, A., Park, A., Aguilar, J., Anderson, W., Santaguida, M., . . . Dylla, S. J. (2015)., Anti-EFNA4 calicheamicin conjugates effectively target triple-negative breast and ovarian tumor-initiating cells to result in sustained tumor regressions, Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 21(18), 4165-4173. doi:10.1158/1078-0432.CCR-15-0695 [doi]
Hassler, M. R., Klisaroska, A., Kollmann, K., Steiner, I., Bilban, M., Schiefer, A. I., . . . Egger, G. (2012)., Antineoplastic activity of the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine in anaplastic large cell lymphoma., Biochimie, 94(11), 2297-2307. doi:10.1016/j.biochi.2012.05.029 [doi]
Hallin J, Bowcut V, Calinisan A, Briere DM, Hargis L, Engstrom LD, Laguer J, Medwid J, Vanderpool D, Lifset E, Trinh D, Hoffman N, Wang X, David Lawson J, Gunn RJ, Smith CR, Thomas NC, Martinson M, Bergstrom A, Sullivan F, Bouhana K, Winski S, He L, Fernandez-Banet J, Pavlicek A, Haling JR, Rahbaek L, Marx MA, Olson P, Christensen JG., Anti-tumor efficacy of a potent and selective non-covalent KRAS(G12D) inhibitor, Nat Med. 2022 Oct;28(10):2171-2182. doi: 10.1038/s41591-022-02007-7. Epub 2022 Oct 10.
Dold, C., Rodriguez Urbiola, C., Wollmann, G., Egerer, L., Muik, A., Bellmann, L., . . . von Laer, D. (2016)., Application of interferon modulators to overcome partial resistance of human ovarian cancers to VSV-GP oncolytic viral therapy., Molecular Therapy Oncolytics, 3, 16021. doi:10.1038/mto.2016.21 [doi]
Cosco, D., Paolino, D., De Angelis, F., Cilurzo, F., Celia, C., Di Marzio, L., . . . Fresta, M. (2015), Aqueous-core PEG-coated PLA nanocapsules for an efficient entrapment of water soluble anticancer drugs and a smart therapeutic response, European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik e.V, 89, 30-39. doi:10.1016/j.ejpb.2014.11.012 [doi]
Was, H., Barszcz, K., Czarnecka, J., Kowalczyk, A., Bernas, T., Uzarowska, E., . . . Sikora, E. (2017)., Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice., Oncotarget, 8(6), 9303-9322. doi:10.18632/oncotarget.14066 [doi]
Londono-Joshi, A. I., Oliver, P. G., Li, Y., Lee, C. H., Forero-Torres, A., LoBuglio, A. F., & Buchsbaum, D. J. (2012)., Basal-like breast cancer stem cells are sensitive to anti-DR5 mediated cytotoxicity, Breast Cancer Research and Treatment, 133(2), 437-445. doi:10.1007/s10549-011-1763-0 [doi]
Khawaja H, Briggs R, Latimer CH, Rassel M, Griffin D, Hanson L, Bardelli A, Di Nicolantonio F, McDade SS, Scott CJ, Lambe S, Maurya M, Lindner AU, Prehn JHM, Sousa J, Winnington C, LaBonte MJ, Ross S, Van Schaeybroeck S., Bcl-xL Is a Key Mediator of Apoptosis Following KRASG12C Inhibition in KRASG12C-mutant Colorectal Cancer., Mol Cancer Ther. 2023 Jan 3;22(1):135-149. doi: 10.1158/1535-7163.MCT-22-0301.
Wang, L., Park, P., Zhang, H., La Marca, F., Claeson, A., Than, K., . . . Lin, C. Y. (2012)., BMP-2 inhibits tumor growth of human renal cell carcinoma and induces bone formation, International Journal of Cancer.Journal International Du Cancer, 131(8), 1941-1950. doi:10.1002/ijc.27444 [doi]
Wang, L., Park, P., La Marca, F., Than, K., Rahman, S., & Lin, C. Y. (2013)., Bone formation induced by BMP-2 in human osteosarcoma cells., International Journal of Oncology, 43(4), 1095-1102. doi:10.3892/ijo.2013.2030 [doi]
Gaudio, E., Tarantelli, C., Ponzoni, M., Odore, E., Rezai, K., Bernasconi, E., . . . Bertoni, F. (2016)., Bromodomain inhibitor OTX015 (MK-8628) combined with targeted agents shows strong in vivo antitumor activity in lymphoma, Oncotarget, 7(36), 58142-58147. doi:10.18632/oncotarget.10983 [doi]
Sharma, Sambad; Wu, Shih-Ying; Jimenez, Hugo; Xing, Fei; Zhu, Dongqin; Liu, Yin; Wu, Kerui; Tyagi, Abhishek; Zhao, Dan; Lo, Hui-Wen; Metheny-Barlow, Linda; Sun, Peiqing; Bourland, John D; Chan, Michael D; Thomas, Alexandra; Barbault, Alexandre; DAgostino, Ralph B; Whitlow, Christopher T; Kirchner, Volker; Blackman, Carl; Pasche, Boris; Watabe, Kounosuke;, Ca2+ and CACNA1H mediate targeted suppression of breast cancer brain metastasis by AM RF EMF., EBioMedicine Vol.44, 2019
Gatt, S., & Dagan, A. (2012), Cancer and sphingolipid storage disease therapy using novel synthetic analogs of sphingolipids, Chemistry and Physics of Lipids, 165(4), 462-474. doi:10.1016/j.chemphyslip.2012.02.006 [doi]
Sullivan KMC, Vilalta M, Ertl LS, Wang Y, Dunlap C, Ebsworth K, Zhao BN, Li S, Zeng Y, Miao Z, Fan P, Mali V, Lange C, McMurtrie D, Yang J, Lui R, Scamp R, Chhina V, Kumamoto A, Yau S, Dang T, Easterday A, et al., CCX559 is a potent, orally-administered small molecule PD-L1 inhibitor that induces anti-tumor immunity., PLoS One. 2023 Jun 7;18(6):e0286724. doi: 10.1371/journal.pone.0286724. eCollection 2023.
Castelli R, Taranto S, Furiassi L, Bozza N, Marseglia G, Ferlenghi F, Rivara S, Retini M, Bedini A, Spadoni G, Matarazzo S, Ronca R, Presta M, Mor M, Giacomini A., Chemical modification of NSC12 leads to a specific FGF-trap with antitumor activity in multiple myeloma, Eur J Med Chem. 2021 Oct 5;221:113529. doi: 10.1016/j.ejmech.2021.113529. Epub 2021 May 5.
Liapis E, Karlas A, Klemm U, Ntziachristos V., Chemotherapeutic effects on breast tumor hemodynamics revealed by eigenspectra multispectral optoacoustic tomography (eMSOT), Theranostics. 2021 Jun 26;11(16):7813-7828. doi: 10.7150/thno.56173. eCollection 2021.
Zaoui, K., Bossow, S., Grossardt, C., Leber, M. F., Springfeld, C., Plinkert, P. K., . . . Ungerechts, G. (2012)., Chemovirotherapy for head and neck squamous cell carcinoma with EGFR-targeted and CD/UPRT-armed oncolytic measles virus., Cancer Gene Therapy, 19(3), 181-191. doi:10.1038/cgt.2011.75 [doi]
Feng, Yashu; Zhang, Ling; Wu, Jieying; Khadka, Bijay; Fang, Zhigang; Gu, Jiaming; Tang, Baoqiang; Xiao, Ruozhi; Pan, Guangjin; Liu, Jiajun;, CircRNA circ_0000190 inhibits the progression of multiple myeloma through modulating miR-767-5p/MAPK4 pathway., Journal of experimental & clinical cancer research : CR Vol.38, 2019
Sun, L., Zhang, L., Qian, J., Yang, J., Yi, Q., Dong, W., & Wang, M. (2012)., Combination of atiprimod and the proteasome inhibitor bortezomib induces apoptosis of mantle cell lymphoma in vitro and in vivo., Leukemia Research, 36(3), 363-368. doi:10.1016/j.leukres.2011.09.014 [doi]
Gaudio, E., Tarantelli, C., Kwee, I., Barassi, C., Bernasconi, E., Rinaldi, A., . . . Bertoni, F. (2016)., Combination of the MEK inhibitor pimasertib with BTK or PI3K-delta inhibitors is active in preclinical models of aggressive lymphomas., Annals of Oncology : Official Journal of the European Society for Medical Oncology, 27(6), 1123-1128. doi:10.1093/annonc/mdw131 [doi]
Benguigui, Madeleine; Weitz, Iris S; Timaner, Michael; Kan, Tal; Shechter, Dvir; Perlman, Or; Sivan, Sarit; Raviv, Ziv; Azhari, Haim; Shaked, Yuval;, Copper oxide nanoparticles inhibit pancreatic tumor growth primarily by targeting tumor initiating cells., Scientific reports Vol.9, 2019
Cosco, D., Cilurzo, F., Maiuolo, J., Federico, C., Di Martino, M. T., Cristiano, M. C., . . . Paolino, D. (2015)., Delivery of miR-34a by chitosan/PLGA nanoplexes for the anticancer treatment of multiple myeloma., Scientific Reports, 5, 17579. doi:10.1038/srep17579 [doi]
Yang N, Yang Y, Huang Z, Chen HW., Deregulation of Cholesterol Homeostasis by a Nuclear Hormone Receptor Crosstalk in Advanced Prostate Cancer, Cancers (Basel). 2022 Jun 24;14(13):3110. doi: 10.3390/cancers14133110.
Aasen, Synnøve Nymark; Parajuli, Himalaya; Hoang, Tuyen; Feng, Zichao; Stokke, Krister; Wang, Jiwei; Roy, Kislay; Bjerkvig, Rolf; Knappskog, Stian; Thorsen, Frits;, Effective Treatment of Metastatic Melanoma by Combining MAPK and PI3K Signaling Pathway Inhibitors., International journal of molecular sciences Vol.20, 2019
Shir, A., Ogris, M., Roedl, W., Wagner, E., & Levitzki, A. (2011), EGFR-homing dsRNA activates cancer-targeted immune response and eliminates disseminated EGFR-overexpressing tumors in mice, Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 17(5), 1033-1043. doi:10.1158/1078-0432.CCR-10-1140 [doi]
Krishnamoorthy, Gnana P; Davidson, Natalie R; Leach, Steven D; Zhao, Zhen; Lowe, Scott W; Lee, Gina; Landa, I?igo; Nagarajah, James; Saqcena, Mahesh; Singh, Kamini; Wendel, Hans-Guido; Dogan, Snjezana; Tamarapu, Prasanna P; Blenis, John; Ghossein, Ronald A; Knauf, Jeffrey A; Rätsch, Gunnar; Fagin, James A, EIF1AX and RAS Mutations Cooperate to Drive Thyroid Tumorigenesis through ATF4 and c-MYC., Cancer discovery Vol.9, 2019
Suominen MI, Knuuttila M, Schatz CA, Schlicker A, Vääräniemi J, Sjöholm B, Alhoniemi E, Haendler B, Mumberg D, Käkönen SM, Scholz A., Enhanced Antitumor Efficacy of Radium-223 and Enzalutamide in the Intratibial LNCaP Prostate Cancer Model., Int J Mol Sci. 2023 Jan 22;24(3). pii: 2189. doi: 10.3390/ijms24032189.
La Rocca, Francesco; Airoldi, Irma; Di Carlo, Emma; Marotta, Pina; Falco, Geppino; Simeon, Vittorio; Laurenzana, Ilaria; Trino, Stefania; De Luca, Luciana; Todoerti, Katia; Villani, Oreste; Lackmann, Martin; DAuria, Fiorella; Frassoni, Francesco; Neri, Antonino; Del Vecchio, Luigi; Musto, Pellegrino; Cilloni, Daniela; Caivano, Antonella;, EphA3 targeting reduces in vitro adhesion and invasion and in vivo growth and angiogenesis of multiple myeloma cells., Cellular oncology (Dordrecht) Vol.40, 2017
Zong X, Wang W, Ozes A, Fang F, Sandusky GE, Nephew KP., EZH2-Mediated Downregulation of the Tumor Suppressor DAB2IP Maintains Ovarian Cancer Stem Cells, Cancer Res. 2020 Oct 15;80(20):4371-4385. doi: 10.1158/0008-5472.CAN-20-0458. Epub 2020 Aug 19.
Ronca R, Ghedini GC, Maccarinelli F, Sacco A, Locatelli SL, Foglio E, Taranto S, Grillo E, Matarazzo S, Castelli R, Paganini G, Desantis V, Cattane N, Cattaneo A, Mor M, Carlo-Stella C, Belotti A, Roccaro AM, Presta M, Giacomini A., FGF Trapping Inhibits Multiple Myeloma Growth through c-Myc Degradation-Induced Mitochondrial Oxidative Stress, Cancer Res. 2020 Jun 1;80(11):2340-2354. doi: 10.1158/0008-5472.CAN-19-2714. Epub 2020 Feb 24.
Paolino, D., Licciardi, M., Celia, C., Giammona, G., Fresta, M., & Cavallaro, G. (2012)., Folate-targeted supramolecular vesicular aggregates as a new frontier for effective anticancer treatment in in vivo model., European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik e.V, 82(1), 94-102. doi:10.1016/j.ejpb.2012.06.001 [doi]
Paolino, D., Cosco, D., Celano, M., Moretti, S., Puxeddu, E., Russo, D., & Fresta, M. (2013)., Gemcitabine-loaded biocompatible nanocapsules for the effective treatment of human cancer, Nanomedicine (London, England), 8(2), 193-201. doi:10.2217/nnm.12.101 [doi]
Solimando AG, Da Vià  MC, Leone P, Borrelli P, Croci GA, Tabares P, Brandl A, Di Lernia G, Bianchi FP, Tafuri S, Steinbrunn T, Balduini A, Melaccio A, De Summa S, Argentiero A, Rauert-Wunderlich H, Frassanito MA, Ditonno P, Henke E, Klapper W, Ria R, Terragna C, Rasche L, Rosenwald A, Kortüm KM, Cavo M, Ribatti D, Racanelli V, Einsele H, Vacca A, Beilhack A., Halting the vicious cycle within the multiple myeloma ecosystem: blocking JAM-A on bone marrow endothelial cells restores the angiogenic homeostasis and suppresses tumor progression, Haematologica. 2020 Apr 30:haematol.2019.239913. doi: 10.3324/haematol.2019.239913. Online ahead of print.
Litzenburger, B. C., Creighton, C. J., Tsimelzon, A., Chan, B. T., Hilsenbeck, S. G., Wang, T., . . . Lee, A. V. (2011), High IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapy., Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 17(8), 2314-2327. doi:10.1158/1078-0432.CCR-10-1903 [doi]
Shin, D. Y., Kim, A., Kang, H. J., Park, S., Kim, D. W., & Lee, S. S. (2015)., Histone deacetylase inhibitor romidepsin induces efficient tumor cell lysis via selective down-regulation of LMP1 and c-myc expression in EBV-positive diffuse large B-cell lymphoma, Cancer Letters, 364(2), 89-97. doi:10.1016/j.canlet.2015.03.016 [doi]
Lu, Y., Liu, Y., Oeck, S., & Glazer, P. M. (2018)., Hypoxia promotes resistance to EGFR inhibition in NSCLC cells via the histone demethylases, LSD1 and PLU-1., Molecular Cancer Research : MCR, 16(10), 1458-1469. doi:10.1158/1541-7786.MCR-17-0637 [doi]
Stewart, R., Morrow, M., Hammond, S. A., Mulgrew, K., Marcus, D., Poon, E., . . . McCourt, M. (2015)., Identification and characterization of MEDI4736, an antagonistic anti-PD-L1 monoclonal antibody., Cancer Immunology Research, 3(9), 1052-1062. doi:10.1158/2326-6066.CIR-14-0191 [doi]
Buoncervello, M., Romagnoli, G., Buccarelli, M., Fragale, A., Toschi, E., Parlato, S., . . . Gabriele, L. (2016), IFN-alpha potentiates the direct and immune-mediated antitumor effects of epigenetic drugs on both metastatic and stem cells of colorectal cancer., Oncotarget, 7(18), 26361-26373. doi:10.18632/oncotarget.8379 [doi]
Airoldi, I., Di Carlo, E., Cocco, C., Caci, E., Cilli, M., Sorrentino, C., . . . Pistoia, V. (2009)., IL-12 can target human lung adenocarcinoma cells and normal bronchial epithelial cells surrounding tumor lesions., PloS One, 4(7), e6119. doi:10.1371/journal.pone.0006119 [doi]
Aasen, Synnøve Nymark; Espedal, Heidi; Holte, Christopher Florian; Keunen, Olivier; Karlsen, Tine Veronika; Tenstad, Olav; Maherally, Zaynah; Miletic, Hrvoje; Hoang, Tuyen; Eikeland, Anne Vaag; Baghirov, Habib; Olberg, Dag Erlend; Pilkington, Geoffrey John; Sarkar, Gobinda; Jenkins, Robert B; Sundstrøm, Terje; Bjerkvig, Rolf; Thorsen, Frits;, Improved Drug Delivery to Brain Metastases by Peptide-Mediated Permeabilization of the Blood-Brain Barrier., Molecular cancer therapeutics Vol.18, 2019
Di Martino, M. T., Gulla, A., Gallo Cantafio, M. E., Altomare, E., Amodio, N., Leone, E., . . . Tassone, P. (2014, In vitro and in vivo activity of a novel locked nucleic acid (LNA)-inhibitor-miR-221 against multiple myeloma cells., PloS One, 9(2), e89659. doi:10.1371/journal.pone.0089659 [doi]
Hofmann, M., McCormack, E., Mujic, M., Rossberg, M., Bernd, A., Bereiter-Hahn, J., . . . Kippenberger, S. (2009)., Increased plasma colloid osmotic pressure facilitates the uptake of therapeutic macromolecules in a xenograft tumor model, Neoplasia (New York, N.Y.), 11(8), 812-822.
Kuang Y, Ye N, Kyani A, Ljungman M, Paulsen M, Chen H, Zhou M, Wild C, Chen H, Zhou J, Neamati N., Induction of Genes Implicated in Stress Response and Autophagy by a Novel Quinolin-8-yl-nicotinamide QN523 in Pancreatic Cancer, J Med Chem. 2022 Apr 28;65(8):6133-6156. doi: 10.1021/acs.jmedchem.1c02207. Epub 2022 Apr 19.
Otto, Marius; Blatt, Sebastian; Pabst, Andreas; Mandic, Robert; Schwarz, Johanna; Neff, Andreas; Ziebart, Thomas;, Influence of buffy coat-derived putative endothelial progenitor cells on tumor growth and neovascularization in oral squamous cell carcinoma xenografts., Clinical oral investigations Vol.23, 2019
Boer, J. C., Domanska, U. M., Timmer-Bosscha, H., Boer, I. G., de Haas, C. J., Joseph, J. V., . . . Walenkamp, A. M. (2013), Inhibition of formyl peptide receptor in high-grade astrocytoma by CHemotaxis inhibitory protein of S. aureus., British Journal of Cancer, 108(3), 587-596. doi:10.1038/bjc.2012.603 [doi]
Lamanuzzi, A., Saltarella, I., Desantis, V., Frassanito, M. A., Leone, P., Racanelli, V., . . . Ria, R. (2018)., Inhibition of mTOR complex 2 restrains tumor angiogenesis in multiple myeloma., Oncotarget, 9(29), 20563-20577. doi:10.18632/oncotarget.25003 [doi]
Rodriguez-Barrueco, R., Yu, J., Saucedo-Cuevas, L. P., Olivan, M., Llobet-Navas, D., Putcha, P., . . . Silva, J. M. (2015)., Inhibition of the autocrine IL-6-JAK2-STAT3-calprotectin axis as targeted therapy for HR-/HER2+ breast cancers, Genes & Development, 29(15), 1631-1648. doi:10.1101/gad.262642.115 [doi]
Burns, T. F., Dobromilskaya, I., Murphy, S. C., Gajula, R. P., Thiyagarajan, S., Chatley, S. N., . . . Rudin, C. M. (2013)., Inhibition of TWIST1 leads to activation of oncogene-induced senescence in oncogene-driven non-small cell lung cancer, Molecular Cancer Research : MCR, 11(4), 329-338. doi:10.1158/1541-7786.MCR-12-0456 [doi]
Wang T, Gnanaprakasam JNR, Chen X, Kang S, Xu X, Sun H, Liu L, Rodgers H, Miller E, Cassel TA, Sun Q, Vicente-MuĂąoz S, Warmoes MO, Lin P, Piedra-Quintero ZL, Guerau-de-Arellano M, Cassady KA, Zheng SG, Yang J, Lane AN, Song X, Fan TW, Wang R., Inosine is an alternative carbon source for CD8(+)-T-cell function under glucose restriction, Nat Metab. 2020 Jul;2(7):635-647. doi: 10.1038/s42255-020-0219-4. Epub 2020 Jun 15.
Haas, T. L., Sciuto, M. R., Brunetto, L., Valvo, C., Signore, M., Fiori, M. E., . . . De Maria, R. (2017)., Integrin alpha7 is a functional marker and potential therapeutic target in glioblastoma, Cell Stem Cell, 21(1), 35-50.e9. doi:S1934-5909(17)30137-6 [pii]
Cocco, C., Giuliani, N., Di Carlo, E., Ognio, E., Storti, P., Abeltino, M., . . . Airoldi, I. (2010), Interleukin-27 acts as multifunctional antitumor agent in multiple myeloma., Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 16(16), 4188-4197. doi:10.1158/1078-0432.CCR-10-0173 [doi]
Airoldi, I., Tupone, M. G., Esposito, S., Russo, M. V., Barbarito, G., Cipollone, G., & Di Carlo, E. (2015)., Interleukin-27 re-educates intratumoral myeloid cells and down-regulates stemness genes in non-small cell lung cancer., Oncotarget, 6(6), 3694-3708. doi:2797 [pii]
Fan F, Malvestiti S, Vallet S, Lind J, Garcia-Manteiga JM, Morelli E, Jiang Q, Seckinger A, Hose D, Goldschmidt H, Stadlbauer A, Sun C, Mei H, Pecherstorfer M, Bakiri L, Wagner EF, Tonon G, Sattler M, Hu Y, Tassone P, Jaeger D, Podar K., JunB is a key regulator of multiple myeloma bone marrow angiogenesis, Leukemia. 2021 Dec;35(12):3509-3525. doi: 10.1038/s41375-021-01271-9. Epub 2021 May 18.
Lapenta, Caterina; Donati, Simona; Spadaro, Francesca; Lattanzi, Laura; Urbani, Francesca; Macchia, Iole; Sestili, Paola; Spada, Massimo; Cox, Maria Christina; Belardelli, Filippo; Santini, Stefano M, Lenalidomide improves the therapeutic effect of an interferon-Îą-dendritic cell-based lymphoma vaccine., Cancer immunology, immunotherapy : CII Vol.68, 2019
Balvers, R. K., Belcaid, Z., van den Hengel, S. K., Kloezeman, J., de Vrij, J., Wakimoto, H., . . . Lamfers, M. L. (2014)., Locally-delivered T-cell-derived cellular vehicles efficiently track and deliver adenovirus delta24-RGD to infiltrating glioma., Viruses, 6(8), 3080-3096. doi:10.3390/v6083080 [doi]
Pascual-Pasto G, Resa-Pares C, Castillo-Ecija H, Aschero R, Baulenas-Farres M, Vila-Ubach M, Burgueño V, Balaguer-Lluna L, Cuadrado-Vilanova M, Olaciregui NG, Martinez-Velasco N, Perez-Jaume S, de Alava E, Tirado OM, Lavarino C, Mora J, Carcaboso AM., Low Bcl-2 is a robust biomarker of sensitivity to nab-paclitaxel in Ewing sarcoma, Biochem Pharmacol. 2023 Jan 2;208:115408. doi: 10.1016/j.bcp.2022.115408. Online ahead of print.
Zhou J, Sturtevant D, Love C, Kulkarni A, Biyani N, Kathad U, Thacker E, Dave S, Bhatia K., LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin's lymphoma models and in cells deficient in DNA damage repair., Oncotarget. 2023 Jun 12;14:597-611. doi: 10.18632/oncotarget.28454.
Sato H, Schoenfeld AJ, Siau E, Lu YC, Tai H, Suzawa K, Kubota D, Lui AJW, Qeriqi B, Mattar M, Offin M, Sakaguchi M, Toyooka S, Drilon A, Rosen NX, Kris MG, Solit D, De Stanchina E, Davare MA, Riely GJ, Ladanyi M, Somwar R., MAPK Pathway Alterations Correlate with Poor Survival and Drive Resistance to Therapy in Patients with Lung Cancers Driven by ROS1 Fusions, Clin Cancer Res. 2020 Jun 15;26(12):2932-2945. doi: 10.1158/1078-0432.CCR-19-3321. Epub 2020 Mar 2.
Novoplansky, Ofra; Fury, Matthew; Prasad, Manu; Yegodayev, Ksenia; Zorea, Jonathan; Cohen, Limor; Pelossof, Raphael; Cohen, Liz; Katabi, Nora; Cecchi, Fabiola; Joshua, Ben-Zion; Popovtzer, Aron; Baselga, Jose; Scaltriti, Maurizio; Elkabets, Moshe;, MET activation confers resistance to cetuximab, and prevents HER2 and HER3 upregulation in head and neck cancer, International journal of cancer Vol.145, 2019
Lynam-Lennon, N., Heavey, S., Sommerville, G., Bibby, B. A., Ffrench, B., Quinn, J., . . . Maher, S. G. (2017)., MicroRNA-17 is downregulated in esophageal adenocarcinoma cancer stem-like cells and promotes a radioresistant phenotype, Oncotarget, 8(7), 11400-11413. doi:10.18632/oncotarget.13940 [doi]
Baertsch, M. A., Leber, M. F., Bossow, S., Singh, M., Engeland, C. E., Albert, J., . . . Ungerechts, G. (2014), MicroRNA-mediated multi-tissue detargeting of oncolytic measles virus., Cancer Gene Therapy, 21(9), 373-380. doi:10.1038/cgt.2014.40 [doi]
Liu, R., Shi, P., Nie, Z., Liang, H., Zhou, Z., Chen, W., . . . Chen, C. (2016)., Mifepristone suppresses basal triple-negative breast cancer stem cells by down-regulating KLF5 expression., Theranostics, 6(4), 533-544. doi:10.7150/thno.14315 [doi]
Parvin, Salma; Ramirez-Labrada, Ariel; Aumann, Shlomzion; Lu, XiaoQing; Weich, Natalia; Santiago, Gabriel; Cortizas, Elena M; Sharabi, Eden; Zhang, Yu; Sanchez-Garcia, Isidro; Gentles, Andrew J; Roberts, Evan; Bilbao-Cortes, Daniel; Vega, Francisco; Chapman, Jennifer R; Verdun, Ramiro E; Lossos, Izidore S;, MO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL, Cancer cell Vol.36, 2019
Wennier, S. T., Liu, J., Li, S., Rahman, M. M., Mona, M., & McFadden, G. (2012)., Myxoma virus sensitizes cancer cells to gemcitabine and is an effective oncolytic virotherapeutic in models of disseminated pancreatic cancer., Molecular Therapy : The Journal of the American Society of Gene Therapy, 20(4), 759-768. doi:10.1038/mt.2011.293 [doi]
Sionov, Ronit Vogt; Fainsod-Levi, Tanya; Zelter, Tamir; Polyansky, Lola; Pham, Christine T; Granot, Zvi;, Neutrophil Cathepsin G and Tumor Cell RAGE Facilitate Neutrophil Anti-Tumor Cytotoxicity., Oncoimmunology Vol.8, 2019
Rai R, Dey DK, Benbrook DM, Chandra V., Niclosamide causes lysosome-dependent cell death in endometrial cancer cells and tumors., Biomed Pharmacother. 2023 May;161:114422. doi: 10.1016/j.biopha.2023.114422. Epub 2023 Feb 23.
Chao, M. W., Chu, P. C., Chuang, H. C., Shen, F. H., Chou, C. C., Hsu, E. C., . . . Chen, C. S. (2016)., Non-epigenetic function of HDAC8 in regulating breast cancer stem cells by maintaining Notch1 protein stability., Oncotarget, 7(2), 1796-1807. doi:10.18632/oncotarget.6427 [doi]
Giovannini, C., Baglioni, M., Baron Toaldo, M., Ventrucci, C., D'Adamo, S., Cipone, M., . . . Bolondi, L. (2013)., Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3b phosphorylation and p21 down-regulation in hepatocellular carcinoma., Oncotarget, 4(10), 1618-1631. doi:1221 [pii]
Moschetta, M., Basile, A., Ferrucci, A., Frassanito, M. A., Rao, L., Ria, R., . . . Vacca, A. (2013)., Novel targeting of phospho-cMET overcomes drug resistance and induces antitumor activity in multiple myeloma., Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 19(16), 4371-4382. doi:10.1158/1078-0432.CCR-13-0039 [doi]
Garg, G., Gibbs, J., Belt, B., Powell, M. A., Mutch, D. G., Goedegebuure, P., . . . Spitzer, D. (2014)., Novel treatment option for MUC16-positive malignancies with the targeted TRAIL-based fusion protein meso-TR3., BMC Cancer, 14, 35-2407-14-35. doi:10.1186/1471-2407-14-35 [doi]
Santoro, Angela; Vlachou, Thalia; Luzi, Lucilla; Melloni, Giorgio; Mazzarella, Luca; DElia, Errico; Aobuli, Xieraili; Pasi, Cristina Elisabetta; Reavie, Linsey; Bonetti, Paola; Punzi, Simona; Casoli, Lucia; Sab??, Arianna; Moroni, Maria Cristina; Dellino, Gaetano Ivan; Amati, Bruno; Nicassio, Francesco; Lanfrancone, Luisa; Pelicci, Pier Giuseppe;, p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value, Cell reports Vol.26, 2019
Ronca R, Taranto S, Corsini M, Tobia C, Ravelli C, Rezzola S, Belleri M, De Cillis F, Cattaneo A, Presta M, Giacomini A., Pentraxin 3 Inhibits the Angiogenic Potential of Multiple Myeloma Cells, Cancers (Basel). 2021 May 8;13(9):2255. doi: 10.3390/cancers13092255.
Pleniceanu, O., Shukrun, R., Omer, D., Vax, E., Kanter, I., Dziedzic, K., . . . Dekel, B. (2017)., Peroxisome proliferator-activated receptor gamma (PPARgamma) is central to the initiation and propagation of human angiomyolipoma, suggesting its potential as a therapeutic target, EMBO Molecular Medicine, 9(4), 508-530. doi:10.15252/emmm.201506111 [doi]
Spriano F, Sartori G, Tarantelli C, Barreca M, Golino G, Rinaldi A, Napoli S, Mascia M, Scalise L, Arribas AJ, Cascione L, Zucca E, Stathis A, Gaudio E, Bertoni F., Pharmacologic screen identifies active combinations with BET inhibitors and LRRK2 as a novel putative target in lymphoma, EJHaem. 2022 Jul 27;3(3):764-774. doi: 10.1002/jha2.535. eCollection 2022 Aug.
Zhu, C., Cheng, K. W., Ouyang, N., Huang, L., Sun, Y., Constantinides, P., & Rigas, B. (2012)., Phosphosulindac (OXT-328) selectively targets breast cancer stem cells in vitro and in human breast cancer xenografts., Stem Cells (Dayton, Ohio), 30(10), 2065-2075. doi:10.1002/stem.1139 [doi]
Kolev, V. N., Wright, Q. G., Vidal, C. M., Ring, J. E., Shapiro, I. M., Ricono, J., . . . Xu, Q. (2015)., PI3K/mTOR dual inhibitor VS-5584 preferentially targets cancer stem cells., null
Di Meo, C., Cilurzo, F., Licciardi, M., Scialabba, C., Sabia, R., Paolino, D., . . . Matricardi, P. (2015)., Polyaspartamide-doxorubicin conjugate as potential prodrug for anticancer therapy., Pharmaceutical Research, 32(5), 1557-1569. doi:10.1007/s11095-014-1557-2 [doi]
Deb G, Wingelhofer B, Amaral FMR, Maiques-Diaz A, Chadwick JA, Spencer GJ, Williams EL, Leong HS, Maes T, Somervaille TCP., Pre-clinical activity of combined LSD1 and mTORC1 inhibition in MLL-translocated acute myeloid leukaemia, Leukemia. 2020 May;34(5):1266-1277. doi: 10.1038/s41375-019-0659-6. Epub 2019 Nov 28.
Torres-Guzman, R., Calsina, B., Hermoso, A., Baquero, C., Alvarez, B., Amat, J., . . . Lallena, M. J. (2017)., Preclinical characterization of abemaciclib in hormone receptor positive breast cancer., Oncotarget, 8(41), 69493-69507. doi:10.18632/oncotarget.17778 [doi]
Friedrich, M., Henn, A., Raum, T., Bajtus, M., Matthes, K., Hendrich, L., . . . Rattel, B. (2014)., Preclinical characterization of AMG 330, a CD3/CD33-bispecific T-cell-engaging antibody with potential for treatment of acute myelogenous leukemia., Molecular Cancer Therapeutics, 13(6), 1549-1557. doi:10.1158/1535-7163.MCT-13-0956 [doi]
Hammer S, Hagemann UB, Zitzmann-Kolbe S, Larsen A, Ellingsen C, Geraudie S, Grant D, Indrevoll B, Smeets R, von Ahsen O, Kristian A, Lejeune P, Hennekes H, Karlsson J, Bjerke RM, Ryan OB, Cuthbertson AS, Mumberg D., Preclinical Efficacy of a PSMA-Targeted Thorium-227 Conjugate (PSMA-TTC), a Targeted Alpha Therapy for Prostate Cancer, Clin Cancer Res. 2020 Apr 15;26(8):1985-1996. doi: 10.1158/1078-0432.CCR-19-2268. Epub 2019 Dec 12.
Hammer, Stefanie; Hagemann, Urs B; Zitzmann-Kolbe, Sabine; Larsen, Aasmund; Ellingsen, Christine; Geraudie, Solene; Grant, Derek; Indrevoll, Baard; Smeets, Roger; von Ahsen, Oliver; Kristian, Alexander; Lejeune, Pascale; Hennekes, Hartwig; Karlsson, Jenny; Bjerke, Roger M; Ryan, Olav B; Cuthbertson, Alan S; Mumberg, Dominik;, Preclinical efficacy of a PSMA-targeted thorium-227 conjugate (PSMA-TTC), a targeted alpha therapy for prostate cancer., Clinical cancer research : an official journal of the American Association for Cancer Research Vol.9, 2019
Sommer, A., Kopitz, C., Schatz, C. A., Nising, C. F., Mahlert, C., Lerchen, H. G., . . . Kreft, B. (2016)., Preclinical efficacy of the auristatin-based antibody-drug conjugate BAY 1187982 for the treatment of FGFR2-positive solid tumors, Cancer Research, 76(21), 6331-6339. doi:0008-5472.CAN-16-0180 [pii]
Smit, J. K., Faber, H., Niemantsverdriet, M., Baanstra, M., Bussink, J., Hollema, H., . . . Coppes, R. P. (2013)., Prediction of response to radiotherapy in the treatment of esophageal cancer using stem cell markers., Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology, 107(3), 434-441. doi:10.1016/j.radonc.2013.03.027 [doi]
Kim, S., Jin, H., Seo, H. R., Lee, H. J., & Lee, Y. S. (2018)., Regulating BRCA1 protein stability by cathepsin S-mediated ubiquitin degradation., Cell Death and Differentiation, doi:10.1038/s41418-018-0153-0 [doi]
Amodio, Nicola; Gallo Cantafio, Maria Eugenia; Botta, Cirino; Agosti, Valter; Federico, Cinzia; Caracciolo, Daniele; Ronchetti, Domenica; Rossi, Marco; Driessen, Christoph; Neri, Antonino; Tagliaferri, Pierosandro; Tassone, Pierfrancesco;, Replacement of miR-155 Elicits Tumor Suppressive Activity and Antagonizes Bortezomib Resistance in Multiple Myeloma, Cancers Vol.11, 2019
Badarni, Mai; Prasad, Manu; Balaban, Noa; Zorea, Jonathan; Yegodayev, Ksenia M; Joshua, Ben-Zion; Dinur, Anat Bahat; GrĂŠnman, Reidar; Rotblat, Barak; Cohen, Limor; Elkabets, Moshe, Repression of AXL expression by AP-1/JNK blockage overcomes resistance to PI3Ka therapy, JCI insight Vol.5, 2019
Liapis E, Klemm U, Karlas A, Reber J, Ntziachristos V., Resolution of Spatial and Temporal Heterogeneity in Bevacizumab-Treated Breast Tumors by Eigenspectra Multispectral Optoacoustic Tomography, Cancer Res. 2020 Dec 1;80(23):5291-5304. doi: 10.1158/0008-5472.CAN-20-1011. Epub 2020 Sep 29.
Smith BD, Kaufman MD, Lu WP, Gupta A, Leary CB, Wise SC, Rutkoski TJ, Ahn YM, Al-Ani G, Bulfer SL, Caldwell TM, Chun L, Ensinger CL, Hood MM, McKinley A, Patt WC, Ruiz-Soto R, Su Y, Telikepalli H, Town A, Turner BA, Vogeti L, Vogeti S, Yates K, Janku F, Abdul Razak AR, Rosen O, Heinrich MC, Flynn DL., Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants., Cancer Cell. 2019 May 13;35(5):738-751.e9
Dahlmann, M., & Stein, U. (2015)., RNA interference for antimetastatic therapy., Methods in Molecular Biology (Clifton, N.J.), 1317, 153-165. doi:10.1007/978-1-4939-2727-2_10 [doi]
D'Alesio, C., Punzi, S., Cicalese, A., Fornasari, L., Furia, L., Riva, L., . . . Lanfrancone, L. (2016)., RNAi screens identify CHD4 as an essential gene in breast cancer growth, Oncotarget, 7(49), 80901-80915. doi:10.18632/oncotarget.12646 [doi]
Sebastiani J, Puxeddu M, Nalli M, Bai R, Altieri L, Rovella P, Gaudio E, Trisciuoglio D, Spriano F, Lavia P, Fionda C, Masci D, Urbani A, Bigogno C, Dondio G, Hamel E, Bertoni F, Silvestri R, La Regina G., RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo, Eur J Med Chem. 2023 Jan 15;246:114997. doi: 10.1016/j.ejmech.2022.114997. Epub 2022 Dec 5.
Sebastiani J, Puxeddu M, Nalli M, Bai R, Altieri L, Rovella P, Gaudio E, Trisciuoglio D, Spriano F, Lavia P, Fionda C, Masci D, Urbani A, Bigogno C, Dondio G, Hamel E, Bertoni F, Silvestri R, La Regina G., RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo., Eur J Med Chem. 2023 Jan 15;246:114997. doi: 10.1016/j.ejmech.2022.114997. Epub 2022 Dec 5.
Fischer, M. M., Yeung, V. P., Cattaruzza, F., Hussein, R., Yen, W. C., Murriel, C., . . . Hoey, T. (2017)., RSPO3 antagonism inhibits growth and tumorigenicity in colorectal tumors harboring common wnt pathway mutations., Scientific Reports, 7(1), 15270-017-15704-y. doi:10.1038/s41598-017-15704-y [doi]
Spriano, Filippo; Tarantelli, Chiara; Gaudio, Eugenio; Gerlach, Magdalena M; Priebe, Valdemar; Cascione, Luciano; Bernasconi, Elena; Targa, Altea; Mascia, Michele; Dirnhofer, Stefan; Stathis, Anastasios; Zucca, Emanuele; Bertoni, Francesco;, Single and combined BTK and PI3Kδ inhibition with acalabrutinib and ACP-319 in pre-clinical models of aggressive lymphomas., British journal of haematology Vol.187, 2019
He, M., Tan, B., Vasan, K., Yuan, H., Cheng, F., Ramos da Silva, S., . . . Gao, S. J. (2017)., SIRT1 and AMPK pathways are essential for the proliferation and survival of primary effusion lymphoma cells, The Journal of Pathology, 242(3), 309-321. doi:10.1002/path.4905 [doi]
Pascual-Pasto G, Castillo-Ecija H, Unceta N, Aschero R, Resa-Pares C, Gómez-Caballero A, Vila-Ubach M, Muñoz-Aznar O, Suñol M, Burgueño V, Gomez-Gonzalez S, Sosnik A, Ibarra M, Schaiquevich P, de Álava E, Tirado OM, Mora J, Carcaboso AM., SPARC-mediated long-term retention of nab-paclitaxel in pediatric sarcomas, J Control Release. 2022 Feb;342:81-92. doi: 10.1016/j.jconrel.2021.12.035. Epub 2021 Dec 30.
Li, X., Wu, J. B., Li, Q., Shigemura, K., Chung, L. W., & Huang, W. C. (2016)., SREBP-2 promotes stem cell-like properties and metastasis by transcriptional activation of c-myc in prostate cancer., Oncotarget, 7(11), 12869-12884. doi:10.18632/oncotarget.7331 [doi]
Mensah AA, Spriano F, Sartori G, Priebe V, Cascione L, Gaudio E, Tarantelli C, Civanelli E, Aresu L, Rinaldi A, Damia G, Lovati E, Zucca E, Stathis A, Pietra C, Bertoni F., Study of the antilymphoma activity of pracinostat reveals different sensitivities of DLBCL cells to HDAC inhibitors, Blood Adv. 2021 May 25;5(10):2467-2480. doi: 10.1182/bloodadvances.2020003566.
Patyna, S., Laird, A. D., Mendel, D. B., O'farrell, A. M., Liang, C., Guan, H., . . . Hu-Lowe, D. (2006)., SU14813: A novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity, Molecular Cancer Therapeutics, 5(7), 1774-1782. doi:5/7/1774 [pii]
Melis, M. H., Simpson, K. L., Dovedi, S. J., Welman, A., MacFarlane, M., Dive, C., . . . Illidge, T. M. (2013)., Sustained tumour eradication after induced caspase-3 activation and synchronous tumour apoptosis requires an intact host immune response, Cell Death and Differentiation, 20(5), 765-773. doi:10.1038/cdd.2013.8 [doi]
Galuppo, R., Maynard, E., Shah, M., Daily, M. F., Chen, C., Spear, B. T., & Gedaly, R. (2014)., Synergistic inhibition of HCC and liver cancer stem cell proliferation by targeting RAS/RAF/MAPK and WNT/beta-catenin pathways, Anticancer Research, 34(4), 1709-1713. doi:34/4/1709 [pii]
Rao, L., De Veirman, K., Giannico, D., Saltarella, I., Desantis, V., Frassanito, M. A., . . . Vacca, A. (2018)., Targeting angiogenesis in multiple myeloma by the VEGF and HGF blocking DARPin((R)) protein MP0250: A preclinical study, Oncotarget, 9(17), 13366-13381. doi:10.18632/oncotarget.24351 [doi]
Zhang X, Huang Z, Wang J, Ma Z, Yang J, Corey E, Evans CP, Yu AM, Chen HW., Targeting Feedforward Loops Formed by Nuclear Receptor ROR? and Kinase PBK in mCRPC with Hyperactive AR Signaling, Cancers (Basel). 2021 Apr 1;13(7):1672. doi: 10.3390/cancers13071672.
Leone, E., Morelli, E., Di Martino, M. T., Amodio, N., Foresta, U., Gulla, A., . . . Tassone, P. (2013)., Targeting miR-21 inhibits in vitro and in vivo multiple myeloma cell growth, Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 19(8), 2096-2106. doi:10.1158/1078-0432.CCR-12-3325 [doi]
Raimondi, L., Amodio, N., Di Martino, M. T., Altomare, E., Leotta, M., Caracciolo, D., . . . Tassone, P. (2014), Targeting of multiple myeloma-related angiogenesis by miR-199a-5p mimics: In vitro and in vivo anti-tumor activity, Oncotarget, 5(10), 3039-3054. doi:1747 [pii]
Stafman, L. L., Mruthyunjayappa, S., Waters, A. M., Garner, E. F., Aye, J. M., Stewart, J. E., . . . Beierle, E. A. (2018)., Targeting PIM kinase as a therapeutic strategy in human hepatoblastoma., Oncotarget, 9(32), 22665-22679. doi:10.18632/oncotarget.25205 [doi]
Gedaly, R., Galuppo, R., Daily, M. F., Shah, M., Maynard, E., Chen, C., . . . Spear, B. T. (2014)., Targeting the Wnt/beta-catenin signaling pathway in liver cancer stem cells and hepatocellular carcinoma cell lines with FH535., PloS One, 9(6), e99272. doi:10.1371/journal.pone.0099272 [doi]
Scionti F, Juli G, Rocca R, Polerà N, Nadai M, Grillone K, Caracciolo D, Riillo C, Altomare E, Ascrizzi S, Caparello B, Cerra M, Arbitrio M, Richter SN, Artese A, Alcaro S, Tagliaferri P, Tassone P, Di Martino MT., TERRA G-quadruplex stabilization as a new therapeutic strategy for multiple myeloma., J Exp Clin Cancer Res. 2023 Mar 27;42(1):71. doi: 10.1186/s13046-023-02633-0.
Davidi, S., Fremder, E., Kan, T., Raviv, Z., Timaner, M., Karin, N., . . . Shaked, Y. (2017), The antiangiogenic role of the pro-inflammatory cytokine interleukin-31., Oncotarget, 8(10), 16430-16444. doi:10.18632/oncotarget.14857 [doi]
Boi, M., Gaudio, E., Bonetti, P., Kwee, I., Bernasconi, E., Tarantelli, C., . . . Bertoni, F. (2015)., The BET bromodomain inhibitor OTX015 affects pathogenetic pathways in preclinical B-cell tumor models and synergizes with targeted drugs., Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 21(7), 1628-1638. doi:10.1158/1078-0432.CCR-14-1561 [doi]
Nguyen MR, Ma E, Wyatt D, Knight KL, Osipo C., The effect of an exopolysaccharide probiotic molecule from Bacillus subtilis on breast cancer cells., Front Oncol. 2023 Nov 23;13:1292635. doi: 10.3389/fonc.2023.1292635. eCollection 2023.
Laurent, S., Queirolo, P., Boero, S., Salvi, S., Piccioli, P., Boccardo, S., . . . Pistillo, M. P. (2013)., The engagement of CTLA-4 on primary melanoma cell lines induces antibody-dependent cellular cytotoxicity and TNF-alpha production., Journal of Translational Medicine, 11, 108-5876-11-108. doi:10.1186/1479-5876-11-108 [doi]
Adam, C., Baeurle, A., Brodsky, J. L., Wipf, P., Schrama, D., Becker, J. C., & Houben, R. (2014), The HSP70 modulator MAL3-101 inhibits merkel cell carcinoma., PloS One, 9(4), e92041. doi:10.1371/journal.pone.0092041 [doi]
Fareh, M., Turchi, L., Virolle, V., Debruyne, D., Almairac, F., de-la-Forest Divonne, S., . . . Virolle, T. (2012)., The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network., Cell Death and Differentiation, 19(2), 232-244. doi:10.1038/cdd.2011.89 [doi]
Ordonez, J. L., Amaral, A. T., Carcaboso, A. M., Herrero-Martin, D., del Carmen Garcia-Macias, M., Sevillano, V., . . . de Alava, E. (2015, The PARP inhibitor olaparib enhances the sensitivity of ewing sarcoma to trabectedin, Oncotarget, 6(22), 18875-18890. doi:10.18632/oncotarget.4303 [doi]
Yajuk O, Baron M, Toker S, Zelter T, Fainsod-Levi T, Granot Z., The PD-L1/PD-1 Axis Blocks Neutrophil Cytotoxicity in Cancer, Cells. 2021 Jun 15;10(6):1510. doi: 10.3390/cells10061510.
Abbruzzese, C., Catalogna, G., Gallo, E., di Martino, S., Mileo, A. M., Carosi, M., . . . Paggi, M. G. (2017)., The small molecule SI113 synergizes with mitotic spindle poisons in arresting the growth of human glioblastoma multiforme., Oncotarget, 8(67), 110743-110755. doi:10.18632/oncotarget.22500 [doi]
Komar-Stossel, C., Gross, E., Dery, E., Corchia, N., Meir, K., Fried, I., & Abramovitch, R. (2014), TL-118 and gemcitabine drug combination display therapeutic efficacy in a MYCN amplified orthotopic neuroblastoma murine model--evaluation by MRI, PloS One, 9(3), e90224. doi:10.1371/journal.pone.0090224 [doi]
Cheng, K. W., Mattheolabakis, G., Wong, C. C., Ouyang, N., Huang, L., Constantinides, P. P., & Rigas, B. (2012)., Topical phospho-sulindac (OXT-328) is effective in the treatment of non-melanoma skin cancer., International Journal of Oncology, 41(4), 1199-1203. doi:10.3892/ijo.2012.1577 [doi]
Qin A, Qin Y, Lee J, Musket A, Ying M, Krenciute G, Marincola FM, Yao ZQ, Musich PR, Xie Q., Tyrosine kinase signaling-independent MET-targeting with CAR-T cells, J Transl Med. 2023 Oct 1;21(1):682. doi: 10.1186/s12967-023-04521-9.
Signore, M., Buccarelli, M., Pilozzi, E., De Luca, G., Cappellari, M., Fanciulli, M., . . . Ricci-Vitiani, L. (2016)., UCN-01 enhances cytotoxicity of irinotecan in colorectal cancer stem-like cells by impairing DNA damage response, Oncotarget, 7(28), 44113-44128. doi:10.18632/oncotarget.9859 [doi]
Dey, J., Deckwerth, T. L., Kerwin, W. S., Casalini, J. R., Merrell, A. J., Grenley, M. O., . . . Klinghoffer, R. A. (2017)., Voruciclib, a clinical stage oral CDK9 inhibitor, represses MCL-1 and sensitizes high-risk diffuse large B-cell lymphoma to BCL2 inhibition, Scientific Reports, 7(1), 18007-017-18368-w. doi:10.1038/s41598-017-18368-w [doi]
Punzi, Simona; Balestrieri, Chiara; DAlesio, Carolina; Bossi, Daniela; Dellino, Gaetano Ivan; Gatti, Elena; Pruneri, Giancarlo; Criscitiello, Carmen; Lovati, Giulia; Meliksetyan, Marine; Carugo, Alessandro; Curigliano, Giuseppe; Natoli, Gioacchino; Pelicci, Pier Giuseppe; Lanfrancone, Luisa;, WDR5 inhibition halts metastasis dissemination by repressing the mesenchymal phenotype of breast cancer cells., Breast cancer research : BCR Vol.21, 2019
Fischer, M. M., Cancilla, B., Yeung, V. P., Cattaruzza, F., Chartier, C., Murriel, C. L., . . . Hoey, T. (2017)., WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death, Science Advances, 3(6), e1700090. doi:10.1126/sciadv.1700090 [doi]
Sabatino, M. A., Geroni, C., Ganzinelli, M., Ceruti, R., & Broggini, M. (2013)., Zebularine partially reverses GST methylation in prostate cancer cells and restores sensitivity to the DNA minor groove binder brostallicin, Epigenetics, 8(6), 656-665. doi:10.4161/epi.24916 [doi]

Other

Grillo E, Corsini M, Ravelli C, di Somma M, Zammataro L, Monti E, Presta M, Mitola S., A novel variant of VEGFR2 identified by a pan-cancer screening of recurrent somatic mutations in the catalytic domain of tyrosine kinase receptors enhances tumor growth and metastasis, Cancer Lett. 2021 Jan 1;496:84-92. doi: 10.1016/j.canlet.2020.09.027. Epub 2020 Oct 6.
O'Kelly D, Campbell J 3rd, Gerberich JL, Karbasi P, Malladi V, Jamieson A, Wang L, Mason RP., A scalable open-source MATLAB toolbox for reconstruction and analysis of multispectral optoacoustic tomography data, Sci Rep. 2021 Oct 6;11(1):19872. doi: 10.1038/s41598-021-97726-1.
Bownes LV, Williams AP, Marayati R, Stafman LL, Markert H, Quinn CH, Wadhwani N, Aye JM, Stewart JE, Yoon KJ, Mroczek-Musulman E, Beierle EA., EZH2 inhibition decreases neuroblastoma proliferation and in vivo tumor growth, PLoS One. 2021 Mar 9;16(3):e0246244. doi: 10.1371/journal.pone.0246244. eCollection 2021.
Solimando AG, Da Viŕ MC, Leone P, Borrelli P, Croci GA, Tabares P, Brandl A, Di Lernia G, Bianchi FP, Tafuri S, Steinbrunn T, Balduini A, Melaccio A, De Summa S, Argentiero A, Rauert-Wunderlich H, Frassanito MA, Ditonno P, Henke E, Klapper W, Ria R, Terragna C, Rasche L, Rosenwald A, Kortüm MK, Cavo M, Ribatti D, Racanelli V, Einsele H, Vacca A, Beilhack A., Halting the vicious cycle within the multiple myeloma ecosystem: blocking JAM-A on bone marrow endothelial cells restores angiogenic homeostasis and suppresses tumor progression, Haematologica. 2021 Jul 1;106(7):1943-1956. doi: 10.3324/haematol.2019.239913.
Ghosh M, Saha S, Bettke J, Nagar R, Parrales A, Iwakuma T, van der Velden AWM, Martinez LA., Mutant p53 suppresses innate immune signaling to promote tumorigenesis, Cancer Cell. 2021 Apr 12;39(4):494-508.e5. doi: 10.1016/j.ccell.2021.01.003. Epub 2021 Feb 4.
Kosenko A, Salame TM, Fridlander G, Barash I., Newly characterized bovine mammary stromal region with epithelial properties supports representative epithelial outgrowth development from transplanted stem cells, Cell Tissue Res. 2021 Oct 26. doi: 10.1007/s00441-021-03545-1. Online ahead of print.
Urbano N, Scimeca M, Tolomeo A, Dimiccoli V, Bonanno E, Schillaci O., Novel Biological and Molecular Characterization in Radiopharmaceutical Preclinical Design, J Clin Med. 2021 Oct 21;10(21):4850. doi: 10.3390/jcm10214850.
Marayati R, Stafman LL, Williams AP, Bownes LV, Quinn CH, Aye JM, Stewart JE, Yoon KJ, Anderson JC, Willey CD, Beierle EA., PIM kinases mediate resistance to cisplatin chemotherapy in hepatoblastoma, Sci Rep. 2021 Mar 16;11(1):5984. doi: 10.1038/s41598-021-85289-0.
Castillo-Ecija H, Pascual-Pasto G, Perez-Jaume S, Resa-Pares C, Vila-Ubach M, Monterrubio C, Jimenez-Cabaco A, Baulenas-Farres M, Muńoz-Aznar O, Salvador N, Cuadrado-Vilanova M, Olaciregui NG, Balaguer-Lluna L, Burgueńo V, Vicario FJ, Manzanares A, Castańeda A, Santa-Maria V, Cruz O, Celis V, Morales La Madrid A, Garraus M, Gorostegui M, Vancells M, Carrasco R, Krauel L, Torner F, Suńol M, Lavarino C, Mora J, Carcaboso AM., Prognostic value of patient-derived xenograft engraftment in pediatric sarcomas, J Pathol Clin Res. 2021 Jul;7(4):338-349. doi: 10.1002/cjp2.210. Epub 2021 Apr 9.
Appolloni I, Alessandrini F, Menotti L, Avitabile E, Marubbi D, Piga N, Ceresa D, Piaggio F, Campadelli-Fiume G, Malatesta P., Specificity, Safety, Efficacy of EGFRvIII-Retargeted Oncolytic HSV for Xenotransplanted Human Glioblastoma, Viruses. 2021 Aug 24;13(9):1677. doi: 10.3390/v13091677.
Jayaram DR, Frost S, Argov C, Liju VB, Anto NP, Muraleedharan A, Ben-Ari A, Sinay R, Smoly I, Novoplansky O, Isakov N, Toiber D, Keasar C, Elkabets M, Yeger-Lotem E, Livneh E., Unraveling the hidden role of a uORF-encoded peptide as a kinase inhibitor of PKCs, Proc Natl Acad Sci U S A. 2021 Oct 5;118(40):e2018899118. doi: 10.1073/pnas.2018899118. Epub 2021 Sep 30.

Transplantation

Maldonado, A. A., Cristobal, L., Martin-Lopez, J., Mallen, M., Garcia-Honduvilla, N., & Bujan, J. (2014)., A novel model of human skin pressure ulcers in mice., PloS One, 9(10), e109003. doi:10.1371/journal.pone.0109003 [doi]
Wang, L., Rahman, S., Lin, C. Y., Valdivia, J., Than, K., La Marca, F., & Park, P. (2012)., A novel murine model of human renal cell carcinoma spinal metastasis., Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, 19(6), 881-883. doi:10.1016/j.jocn.2011.10.019 [doi]
Zhang, Y., Zheng, D., Zhou, T., Song, H., Hulsurkar, M., Su, N., . . . Li, W. (2018)., Androgen deprivation promotes neuroendocrine differentiation and angiogenesis through CREB-EZH2-TSP1 pathway in prostate cancers., Nature Communications, 9(1), 4080-018-06177-2. doi:10.1038/s41467-018-06177-2 [doi]
Hamilton NJI, Lee DDH, Gowers KHC, Butler CR, Maughan EF, Jevans B, Orr JC, McCann CJ, Burns AJ, MacNeil S, Birchall MA, O'Callaghan C, Hynds RE, Janes SM., Bioengineered airway epithelial grafts with mucociliary function based on collagen IV- and laminin-containing extracellular matrix scaffolds, Eur Respir J. 2020 Jun 18;55(6):1901200. doi: 10.1183/13993003.01200-2019. Print 2020 Jun.
Magrassi L, Nato G, Delia D, Buffo A., Cell-Autonomous Processes That Impair Xenograft Survival into the Cerebellum, Cerebellum. 2022 Oct;21(5):821-825. doi: 10.1007/s12311-022-01414-3. Epub 2022 May 16.
Milazzo, L., Vulcano, F., Barca, A., Macioce, G., Paldino, E., Rossi, S., . . . Giampaolo, A. (2014)., Cord blood CD34+ cells expanded on wharton's jelly multipotent mesenchymal stromal cells improve the hematopoietic engraftment in NOD/SCID mice, European Journal of Haematology, 93(5), 384-391. doi:10.1111/ejh.12363 [doi]
Westenfelder, C., Gooch, A., Hu, Z., Ahlstrom, J., & Zhang, P. (2017)., Durable control of autoimmune diabetes in mice achieved by intraperitoneal transplantation of "neo-islets," three-dimensional aggregates of allogeneic islet and "mesenchymal stem cells", Stem Cells Translational Medicine, 6(7), 1631-1643. doi:10.1002/sctm.17-0005 [doi]
Argyros, O., Wong, S. P., Gowers, K., & Harbottle, R. P. (2012)., Genetic modification of cancer cells using non-viral, episomal S/MAR vectors for in vivo tumour modelling., PloS One, 7(10), e47920. doi:10.1371/journal.pone.0047920 [doi]
Nato G, Corti A, Parmigiani E, Jachetti E, Lecis D, Colombo MP, Delia D, Buffo A, Magrassi L., Immune-tolerance to human iPS-derived neural progenitors xenografted into the immature cerebellum is overridden by species-specific differences in differentiation timing, Sci Rep. 2021 Jan 12;11(1):651. doi: 10.1038/s41598-020-79502-9.
Glaeser JD, Bao X, Kaneda G, Avalos P, Behrens P, Salehi K, Da X, Chen A, Castaneda C, Nakielski P, Jiang W, Tawackoli W, Sheyn D., iPSC-neural crest derived cells embedded in 3D printable bio-ink promote cranial bone defect repair, Sci Rep. 2022 Nov 4;12(1):18701. doi: 10.1038/s41598-022-22502-8.
Govaere, O., Wouters, J., Petz, M., Vandewynckel, Y. P., Van den Eynde, K., Van den Broeck, A., . . . Roskams, T. (2016)., Laminin-332 sustains chemoresistance and quiescence as part of the human hepatic cancer stem cell niche., Journal of Hepatology, 64(3), 609-617. doi:10.1016/j.jhep.2015.11.011 [doi]
Cristóbal, Lara; de Los Reyes, Nerea; Ortega, Miguel A; Álvarez-Mon, Melchor; García-Honduvilla, Natalio; BujĂĄn, Julia; Maldonado, AndrĂŠs A;, Local Growth Hormone Therapy for Pressure Ulcer Healing on a Human Skin Mouse Model, International journal of molecular sciences Vol.20, 2019
Loebinger, M. R., Kyrtatos, P. G., Turmaine, M., Price, A. N., Pankhurst, Q., Lythgoe, M. F., & Janes, S. M. (2009)., Magnetic resonance imaging of mesenchymal stem cells homing to pulmonary metastases using biocompatible magnetic nanoparticles., Cancer Research, 69(23), 8862-8867. doi:10.1158/0008-5472.CAN-09-1912 [doi]
Elovic, Edan; Etzion, Sharon; Cohen, Smadar;, MiR-499 Responsive Lethal Construct for Removal of Human Embryonic Stem Cells after Cardiac Differentiation, Scientific reports Vol.9, 2019
Marin-Ramos, N. I., Thein, T. Z., Cho, H. Y., Swenson, S. D., Wang, W., Schonthal, A. H., . . . Hofman, F. M. (2018), NEO212 inhibits migration and invasion of glioma stem cells., Molecular Cancer Therapeutics, 17(3), 625-637. doi:10.1158/1535-7163.MCT-17-0591 [doi]
Glaeser JD, Behrens P, Stefanovic T, Salehi K, Papalamprou A, Tawackoli W, Metzger MF, Eberlein S, Nelson T, Arabi Y, Kim K, Baloh RH, Ben-David S, Cohn-Schwartz D, Ryu R, Bae HW, Gazit Z, Sheyn D., Neural crest-derived mesenchymal progenitor cells enhance cranial allograft integration, Stem Cells Transl Med. 2021 May;10(5):797-809. doi: 10.1002/sctm.20-0364. Epub 2021 Jan 29.
Peled, T., Shoham, H., Aschengrau, D., Yackoubov, D., Frei, G., Rosenheimer, G. N., . . . Peled, A. (2012), Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and engraftment, Experimental Hematology, 40(4), 342-55.e1. doi:10.1016/j.exphem.2011.12.005 [doi]
Hargus, G., Ehrlich, M., Arauzo-Bravo, M. J., Hemmer, K., Hallmann, A. L., Reinhardt, P., . . . Zaehres, H. (2014)., Origin-dependent neural cell identities in differentiated human iPSCs in vitro and after transplantation into the mouse brain, Cell Reports, 8(6), 1697-1703. doi:10.1016/j.celrep.2014.08.014 [doi]
Owonikoko, T. K., Zhang, G., Kim, H. S., Stinson, R. M., Bechara, R., Zhang, C., . . . Khuri, F. R. (2016)., Patient-derived xenografts faithfully replicated clinical outcome in a phase II co-clinical trial of arsenic trioxide in relapsed small cell lung cancer, Journal of Translational Medicine, 14(1), 111-016-0861-5. doi:10.1186/s12967-016-0861-5 [doi]
Calles, A., Rubio-Viqueira, B., & Hidalgo, M. (2013)., Primary human non-small cell lung and pancreatic tumorgraft models--utility and applications in drug discovery and tumor biology., Current Protocols in Pharmacology / Editorial Board, S.J.Enna (Editor-in-Chief) ...[Et Al.], Chapter 14, Unit 14.26. doi:10.1002/0471141755.ph1426s61 [doi]
Feys, L., Descamps, B., Vanhove, C., Vermeulen, S., Vandesompele, J. O., Vanderheyden, K., . . . De Wever, O. (2016), Quantitative and functional requirements for bioluminescent cancer models., In Vivo (Athens, Greece), 30(1), 1-11. doi:30/1/1 [pii]
Buzhor, E., Omer, D., Harari-Steinberg, O., Dotan, Z., Vax, E., Pri-Chen, S., . . . Dekel, B. (2013)., Reactivation of NCAM1 defines a subpopulation of human adult kidney epithelial cells with clonogenic and stem/progenitor properties, The American Journal of Pathology, 183(5), 1621-1633. doi:10.1016/j.ajpath.2013.07.034 [doi]
Thomson, A. J., Pierart, H., Meek, S., Bogerman, A., Sutherland, L., Murray, H., . . . Burdon, T. (2012)., Reprogramming pig fetal fibroblasts reveals a functional LIF signaling pathway, Cellular Reprogramming, 14(2), 112-122. doi:10.1089/cell.2011.0078 [doi]
Gudlevičienė Z, Žilinskas K,Kundrotas G, Grubliauskaitė M, Baltriukienė D, Bukelskienė V., Slow-Freezing Cryopreservation Ensures High Ovarian Tissue Quality Followed by In Vivo and In Vitro Methods and Is Safe for Fertility Preservation, Medicina (Kaunas). 2020 Oct 19;56(10):547. doi: 10.3390/medicina56100547.
Yuan, X., Wei, Y., Villasante, A., Ng, J. J. D., Arkonac, D. E., Chao, P. G., & Vunjak-Novakovic, G. (2017)., Stem cell delivery in tissue-specific hydrogel enabled meniscal repair in an orthotopic rat model, Biomaterials, 132, 59-71. doi:S0142-9612(17)30213-2 [pii]
Lima, M. J., Muir, K. R., Docherty, H. M., Drummond, R., McGowan, N. W., Forbes, S., . . . Docherty, K. (2013), Suppression of epithelial-to-mesenchymal transitioning enhances ex vivo reprogramming of human exocrine pancreatic tissue toward functional insulin-producing beta-like cells., Diabetes, 62(8), 2821-2833. doi:10.2337/db12-1256 [doi]
Banerjee, K., Pru, C., Pru, J. K., & Resat, H. (2018)., TAT3 knockdown induces tumor formation by MDA-MB-231 cells, Clinical Oncology and Research, 1(1) doi:10.31487/j.COR.2018.10.002 [doi]
Chartier, C., Raval, J., Axelrod, F., Bond, C., Cain, J., Dee-Hoskins, C., . . . Gurney, A. (2016), Therapeutic targeting of tumor-derived R-spondin attenuates beta-catenin signaling and tumorigenesis in multiple cancer types, Cancer Research, 76(3), 713-723. doi:10.1158/0008-5472.CAN-15-0561 [doi]
Vulcano, F., Milazzo, L., Ciccarelli, C., Barca, A., Agostini, F., Altieri, I., . . . Hassan, H. J. (2012)., Valproic acid affects the engraftment of TPO-expanded cord blood cells in NOD/SCID mice., Experimental Cell Research, 318(4), 400-407. doi:10.1016/j.yexcr.2011.11.012 [doi]
Rauner, G., & Barash, I. (2014), Xanthosine administration does not affect the proportion of epithelial stem cells in bovine mammary tissue, but has a latent negative effect on cell proliferation., Experimental Cell Research, 328(1), 186-196. doi:10.1016/j.yexcr.2014.06.017 [doi]
Petrillo, L. A., Wolf, D. M., Kapoun, A. M., Wang, N. J., Barczak, A., Xiao, Y., . . . Esserman, L. J. (2012)., Xenografts faithfully recapitulate breast cancer-specific gene expression patterns of parent primary breast tumors, Breast Cancer Research and Treatment, 135(3), 913-922. doi:10.1007/s10549-012-2226-y [doi]

Tumor cell growth

Friese-Hamim M, Clark A, Perrin D, Crowley L, Reusch C, Bogatyrova O, Zhang H, Crandall T, Lin J, Ma J, Bachner D, Schmidt J, Schaefer M, Stroh C., Brain penetration and efficacy of tepotinib in orthotopic patient-derived xenograft models of MET-driven non-small cell lung cancer brain metastases, Lung Cancer. 2022 Jan;163:77-86. doi: 10.1016/j.lungcan.2021.11.020. Epub 2021 Dec 11.
Kim M, Vu NT, Wang X, Bulut GB, Wang MH, Uram-Tuculescu C, Pillappa R, Kim S, Chalfant CE., Caspase 9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis, Mol Cancer Res. 2022 Aug 5;20(8):1284-1294. doi: 10.1158/1541-7786.MCR-21-0905.
Zhang B, Chen Y, Bao L, Luo W., GPT2 Is Induced by Hypoxia-Inducible Factor (HIF)-2 and Promotes Glioblastoma Growth, Cells. 2022 Aug 20;11(16):2597. doi: 10.3390/cells11162597.
Peuhu E, Jacquemet G, Scheele CLGJ, Isomursu A, Laisne MC, Koskinen LM, Paatero I, Thol K, Georgiadou M, Guzmán C, Koskinen S, Laiho A, Elo LL, Boström P, Hartiala P, van Rheenen J, Ivaska J., MYO10-filopodia support basement membranes at pre-invasive tumor boundaries, Dev Cell. 2022 Oct 24;57(20):2350-2364.e7. doi: 10.1016/j.devcel.2022.09.016.
Domingo-Ortí I, Ferrer-Torres P, Armiñán A, Vicent MJ, Pineda-Lucena A, Palomino-Schätzlein M., NMR-Based Mitochondria Metabolomic Profiling: A New Approach To Reveal Cancer-Associated Alterations, Anal Chem. 2023 Nov 14;95(45):16539-16548. doi: 10.1021/acs.analchem.3c02432. Epub 2023 Oct 31.
Ghosh M, Saha S, Li J, Montrose DC, Martinez LA., p53 engages the cGAS/STING cytosolic DNA sensing pathway for tumor suppression., Mol Cell. 2023 Jan 19;83(2):266-280.e6. doi: 10.1016/j.molcel.2022.12.023. Epub 2023 Jan 12.
Aschero R, Castillo-Ecija H, Baulenas-Farres M, Resa-Pares C, Jimenez-Cabaco A, Rodriguez E, Monterrubio C, Perez-Jaume S, Suñol M, Chantada GL, Lavarino C, Mora J, Carcaboso AM., Prognostic value of xenograft engraftment in patients with metastatic high-risk neuroblastoma., Pediatr Blood Cancer. 2023 Jun;70(6):e30318. doi: 10.1002/pbc.30318. Epub 2023 Mar 27.
Hidmi S, Nechushtan H, Razin E, Tshori S., Role of Nudt2 in Anchorage-Independent Growth and Cell Migration of Human Melanoma., Int J Mol Sci. 2023 Jun 22;24(13). pii: 10513. doi: 10.3390/ijms241310513.
Quinn CH, Beierle AM, Hutchins SC, Marayati R, Bownes LV, Stewart JE, Markert HR, Erwin MH, Aye JM, Yoon KJ, Friedman GK, Willey CD, Markert JM, Beierle EA., Targeting High-Risk Neuroblastoma Patient-Derived Xenografts with Oncolytic Virotherapy, Cancers (Basel). 2022 Feb 1;14(3):762. doi: 10.3390/cancers14030762.
Howley BV, Mohanty B, Dalton A, Grelet S, Karam J, Dincman T, Howe PH., The ubiquitin E3 ligase ARIH1 regulates hnRNP E1 protein stability, EMT and breast cancer progression, Oncogene. 2022 Mar;41(12):1679-1690. doi: 10.1038/s41388-022-02199-9. Epub 2022 Jan 31.

Tumor growth

Onion, D., Argent, R. H., Reece-Smith, A. M., Craze, M. L., Pineda, R. G., Clarke, P. A., . . . Grabowska, A. M. (2016), 3-dimensional patient-derived lung cancer assays reveal resistance to standards-of-care promoted by stromal cells but sensitivity to histone deacetylase inhibitors., Molecular Cancer Therapeutics, 15(4), 753-763. doi:10.1158/1535-7163.MCT-15-0598 [doi]
Barilani M, Cherubini A, Peli V, Polveraccio F, Bollati V, Guffanti F, Del Gobbo A, Lavazza C, Giovanelli S, Elvassore N, Lazzari L., A circular RNA map for human induced pluripotent stem cells of foetal origin, EBioMedicine. 2020 Jul;57:102848. doi: 10.1016/j.ebiom.2020.102848. Epub 2020 Jun 20.
Howley, B. V., Link, L. A., Grelet, S., El-Sabban, M., & Howe, P. H. (2018)., A CREB3-regulated ER-golgi trafficking signature promotes metastatic progression in breast cancer, Oncogene, 37(10), 1308-1325. doi:10.1038/s41388-017-0023-0 [doi]
Marlow, R., Honeth, G., Lombardi, S., Cariati, M., Hessey, S., Pipili, A., . . . Dontu, G. (2013), A novel model of dormancy for bone metastatic breast cancer cells, Cancer Research, 73(23), 6886-6899. doi:10.1158/0008-5472.CAN-13-0991 [doi]
Dvorkina, M., Nieddu, V., Chakelam, S., Pezzolo, A., Cantilena, S., Leite, A. P., . . . Salomoni, P. (2016), A promyelocytic leukemia protein-thrombospondin-2 axis and the risk of relapse in neuroblastoma, Clinical Cancer Research : An Official Journal of the American Association for Cancer Research, 22(13), 3398-3409. doi:10.1158/1078-0432.CCR-15-2081 [doi]
Kalli, Maria; Mpekris, Fotios; Wong, Chen K; Panagi, Myrofora; Ozturk, Sait; Thiagalingam, Sam; Stylianopoulos, Triantafyllos; Papageorgis, Panagiotis;, Activin A Signaling Regulates IL13R??2 Expression to Promote Breast Cancer Metastasis, Frontiers in oncology Vol.9, 2019
Houben, R., Adam, C., Baeurle, A., Hesbacher, S., Grimm, J., Angermeyer, S., . . . Schrama, D. (2012), An intact retinoblastoma protein-binding site in merkel cell polyomavirus large T antigen is required for promoting growth of merkel cell carcinoma cells, International Journal of Cancer.Journal International Du Cancer, 130(4), 847-856. doi:10.1002/ijc.26076 [doi]
Okada, Seiji; Vaeteewoottacharn, Kulthida; Kariya, Ryusho;, Application of Highly Immunocompromised Mice for the Establishment of Patient-Derived Xenograft (PDX) Models., Cells Vol.8, 2019
Krelin, Y., Berkovich, L., Amit, M., & Gil, Z. (2013)., Association between tumorigenic potential and the fate of cancer cells in a syngeneic melanoma model, PloS One, 8(4), e62124. doi:10.1371/journal.pone.0062124 [doi]
Wang, L., Park, P., La Marca, F., Than, K. D., & Lin, C. Y. (2015), BMP-2 inhibits tumor-initiating ability in human renal cancer stem cells and induces bone formation, Journal of Cancer Research and Clinical Oncology, 141(6), 1013-1024. doi:10.1007/s00432-014-1883-0 [doi]
Frassanito, M. A., Rao, L., Moschetta, M., Ria, R., Di Marzo, L., De Luisi, A., . . . Vacca, A. (2014), Bone marrow fibroblasts parallel multiple myeloma progression in patients and mice: In vitro and in vivo studies, Leukemia, 28(4), 904-916. doi:10.1038/leu.2013.254 [doi]
Codenotti, Silvia; Faggi, Fiorella; Ronca, Roberto; Chiodelli, Paola; Grillo, Elisabetta; Guescini, Michele; Megiorni, Francesca; Marampon, Francesco; Fanzani, Alessandro;, Caveolin-1 enhances metastasis formation in a human model of embryonal rhabdomyosarcoma through Erk signaling cooperation, Cancer letters Vol.449, 2019
Ceresa, Davide; Alessandrini, Francesco; Bosio, Lorenzo; Marubbi, Daniela; Reverberi, Daniele; Malatesta, Paolo; Appolloni, Irene;, Cdh4 Down-Regulation Impairs in Vivo Infiltration and Malignancy in Patients Derived Glioblastoma Cells, International journal of molecular sciences Vol.20, 2019
Fareh, M., Almairac, F., Turchi, L., Burel-Vandenbos, F., Paquis, P., Fontaine, D., . . . Virolle, T. (2017)., Cell-based therapy using miR-302-367 expressing cells represses glioblastoma growth, Cell Death & Disease, 8(3), e2713. doi:10.1038/cddis.2017.117 [doi]
Salvatori, L., Caporuscio, F., Verdina, A., Starace, G., Crispi, S., Nicotra, M. R., . . . Petrangeli, E. (2012)., Cell-to-cell signaling influences the fate of prostate cancer stem cells and their potential to generate more aggressive tumors., PloS One, 7(2), e31467. doi:10.1371/journal.pone.0031467 [doi]
James, M. I., Howells, L. M., Karmokar, A., Higgins, J. A., Greaves, P., Cai, H., . . . Brown, K. (2015)., Characterization and propagation of tumor initiating cells derived from colorectal liver metastases: Trials, tribulations and a cautionary note, PloS One, 10(2), e0117776. doi:10.1371/journal.pone.0117776 [doi]
Schrama, David; Sarosi, Eva-Maria; Adam, Christian; Ritter, Cathrin; Kaemmerer, Ulrike; Klopocki, Eva; KĂśnig, Eva-Maria; Utikal, Jochen; Becker, JĂźrgen C; Houben, Roland;, Characterization of six Merkel cell polyomavirus-positive Merkel cell carcinoma cell lines: Integration pattern suggest that large T antigen truncating events occur before or during integration., International journal of cancer Vol.145, 2019
Arroyo-Crespo JJ, Armiñán A, Charbonnier D, Deladriere C, alomino-Schätzlein M, Lamas-Domingo R, Forteza J, Pineda-Lucena A, Vicent MJ., Characterization of triple-negative breast cancer preclinical models provides functional evidence of metastatic progression, Int J Cancer. 2019 Oct 15;145(8):2267-2281
Achyut, B. R., Shankar, A., Iskander, A. S., Ara, R., Knight, R. A., Scicli, A. G., & Arbab, A. S. (2016)., Chimeric mouse model to track the migration of bone marrow derived cells in glioblastoma following anti-angiogenic treatments, Cancer Biology & Therapy, 17(3), 280-290. doi:10.1080/15384047.2016.1139243 [doi]
Valta M, Ylä-Pelto J, Lan Y, Kähkönen T, Taimen P, Boström PJ, Ettala O, Khan S, Paulin N, Elo LL, Koskinen PJ, Härkönen P, Tuomela J., Critical evaluation of the subcutaneous engraftments of hormone naĂŻve primary prostate cancer, Transl Androl Urol. 2020 Jun;9(3):1120-1134. doi: 10.21037/tau.2020.03.38.
Zhu, L., Cheng, X., Shi, J., Jiacheng, L., Chen, G., Jin, H., . . . Tu, S. P. (2016)., Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis., Oncogene, 35(41), 5388-5399. doi:10.1038/onc.2016.76 [doi]
Zhi, X., Zhao, D., Wang, Z., Zhou, Z., Wang, C., Chen, W., . . . Chen, C. (2013)., E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by targeting the tumor suppressor p21 for ubiquitin-mediated degradation., Cancer Research, 73(1), 385-394. doi:10.1158/0008-5472.CAN-12-0562 [doi]
Kar, A., & Gutierrez-Hartmann, A. (2017)., ESE-1/ELF3 mRNA expression associates with poor survival outcomes in HER2(+) breast cancer patients and is critical for tumorigenesis in HER2(+) breast cancer cells., Oncotarget, 8(41), 69622-69640. doi:10.18632/oncotarget.18710 [doi]
Frosina, G., Ravetti, J. L., Corvo, R., Fella, M., Garre, M. L., Levrero, F., . . . Daga, A. (2018)., Faithful animal modelling of human glioma by using primary initiating cells and its implications for radiosensitization therapy, [ARRIVE 1. Scientific Reports, 8(1), 14191-018-32578-w. doi:10.1038/s41598-018-32578-w [doi]
Tancioni, I., Miller, N. L., Uryu, S., Lawson, C., Jean, C., Chen, X. L., . . . Schlaepfer, D. D. (2015), FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth., Breast Cancer Research : BCR, 17, 47-015-0551-x. doi:10.1186/s13058-015-0551-x [doi]
Tancioni, I., Miller, N. L., Uryu, S., Lawson, C., Jean, C., Chen, X. L., . . . Schlaepfer, D. D. (2015)., FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth., Breast Cancer Research : BCR, 17, 47-015-0551-x. doi:10.1186/s13058-015-0551-x [doi]
Anastasopoulou, Maria; Gorpas, Dimitris; Koch, Maximilian; Liapis, Evangelos; Glasl, Sarah; Klemm, Uwe; Karlas, Angelos; Lasser, Tobias; Ntziachristos, Vasilis, Fluorescence imaging reversion using spatially variant deconvolution., Scientific reports Vol.9, 2019
Stafman, Laura L; Williams, Adele P; Marayati, Raoud; Aye, Jamie M; Markert, Hooper R; Garner, Evan F; Quinn, Colin H; Lallani, Shoeb B; Stewart, Jerry E; Yoon, Karina J; Whelan, Kimberly; Beierle, Elizabeth A;, Focal Adhesion Kinase Inhibition Contributes to Tumor Cell Survival and Motility in Neuroblastoma Patient-Derived Xenografts., Scientific reports Vol.9, 2019
Wardwell-Ozgo, J., Dogruluk, T., Gifford, A., Zhang, Y., Heffernan, T. P., van Doorn, R., . . . Scott, K. L. (2014)., HOXA1 drives melanoma tumor growth and metastasis and elicits an invasion gene expression signature that prognosticates clinical outcome., Oncogene, 33(8), 1017-1026. doi:10.1038/onc.2013.30 [doi]
Gatta, Luisa Benerini; Melocchi, Laura; Bugatti, Mattia; Missale, Francesco; Lonardi, Silvia; Zanetti, Benedetta; Cristinelli, Luca; Belotti, Sandra; Simeone, Claudio; Ronca, Roberto; Grillo, Elisabetta; Licini, Sara; Bresciani, Debora; Tardanico, Regina; Chan, Szeman Ruby; Giurisato, Emanuele; Calza, Stefano; Vermi, William;, Hyper-Activation of STAT3 Sustains Progression of Non-Papillary Basal-Type Bladder Cancer via FOSL1 Regulome., Cancers Vol.11, 2019
Kan T, Feldman E, Timaner M, Raviv Z, Shen-Orr S, Aronheim A, Shaked Y., IL-31 induces antitumor immunity in breast carcinoma, J Immunother Cancer. 2020 Aug;8(2):e001010. doi: 10.1136/jitc-2020-001010.
Desiderio, V., Papagerakis, P., Tirino, V., Zheng, L., Matossian, M., Prince, M. E., . . . Papagerakis, S. (2015)., Increased fucosylation has a pivotal role in invasive and metastatic properties of head and neck cancer stem cells., Oncotarget, 6(1), 71-84. doi:2698 [pii]
Desiderio, V., Papagerakis, P., Tirino, V., Zheng, L., Matossian, M., Prince, M. E., . . . Papagerakis, S. (2015)., Increased fucosylation has a pivotal role in invasive and metastatic properties of head and neck cancer stem cells., Oncotarget, 6(1), 71-84. doi:2698 [pii]
Wu J, Minikes AM, Gao M, Bian H, Li Y, Stockwell BR, Chen ZN, Jiang X, Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling., Nature. 2019 Aug;572(7769):402-406.
Bellavia, D., Raimondo, S., Calabrese, G., Forte, S., Cristaldi, M., Patinella, A., . . . Alessandro, R. (2017)., Interleukin 3- receptor targeted exosomes inhibit in vitro and in vivo chronic myelogenous leukemia cell growth, Theranostics, 7(5), 1333-1345. doi:10.7150/thno.17092 [doi]
Andretta, E., Carton-Garcia, F., Martinez-Barriocanal, A., de Marcondes, P. G., Jimenez-Flores, L. M., Macaya, I., . . . Arango, D. (2017)., Investigation of the role of tyrosine kinase receptor EPHA3 in colorectal cancer., Scientific Reports, 7, 41576. doi:10.1038/srep41576 [doi]
James, M. I., Howells, L. M., Karmokar, A., Higgins, J. A., Greaves, P., Cai, H., . . . Brown, K. (2015)., James, M. I., Howells, L. M., Karmokar, A., Higgins, J. A., Greaves, P., Cai, H., . . . Brown, K. (2015). Characterization and propagation of tumor initiating cells derived from colorectal liver metastases: Trials, tribulations and a cautionary note., PloS One, 10(2), e0117776. doi:10.1371/journal.pone.0117776 [doi]
Escobar-Hoyos, L. F., Shah, R., Roa-Pena, L., Vanner, E. A., Najafian, N., Banach, A., . . . Shroyer, K. R. (2015), Keratin-17 promotes p27KIP1 nuclear export and degradation and offers potential prognostic utility., Cancer Research, 75(17), 3650-3662. doi:10.1158/0008-5472.CAN-15-0293 [doi]
Escobar-Hoyos, L. F., Shah, R., Roa-Pena, L., Vanner, E. A., Najafian, N., Banach, A., . . . Shroyer, K. R. (2015), Keratin-17 promotes p27KIP1 nuclear export and degradation and offers potential prognostic utility., Cancer Research, 75(17), 3650-3662. doi:10.1158/0008-5472.CAN-15-0293 [doi]
Lourenco, S., Teixeira, V. H., Kalber, T., Jose, R. J., Floto, R. A., & Janes, S. M. (2015)., Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors., Journal of Immunology (Baltimore, Md.: 1950), 194(7), 3463-3474. doi:10.4049/jimmunol.1402097 [doi]
Chen, Yu-Chih; Gonzalez, Maria E; Burman, Boris; Zhao, Xintao; Anwar, Talha; Tran, Mai; Medhora, Natasha; Hiziroglu, Ayse B; Lee, Woncheol; Cheng, Yu-Heng; Choi, Yehyun; Yoon, Euisik; Kleer, Celina G;, Mesenchymal Stem/Stromal Cell Engulfment Reveals Metastatic Advantage in Breast Cancer, Cell reports Vol.27, 2019
Carrascosa, C., Obula, R. G., Missiaglia, E., Lehr, H. A., Delorenzi, M., Frattini, M., . . . Mariotti, A. (2012)., MFG-E8/lactadherin regulates cyclins D1/D3 expression and enhances the tumorigenic potential of mammary epithelial cells., Oncogene, 31(12), 1521-1532. doi:10.1038/onc.2011.356 [doi]
Mei, J., Bachoo, R., & Zhang, C. L. (2011), MicroRNA-146a inhibits glioma development by targeting Notch1., Molecular and Cellular Biology, 31(17), 3584-3592. doi:10.1128/MCB.05821-11 [doi]
Zorniak, M., Clark, P. A., & Kuo, J. S. (2015), Myelin-forming cell-specific cadherin-19 is a marker for minimally infiltrative glioblastoma stem-like cells., Journal of Neurosurgery, 122(1), 69-77. doi:10.3171/2014.9.JNS132373 [doi]
Louie, E., Chen, X. F., Coomes, A., Ji, K., Tsirka, S., & Chen, E. I. (2013)., Neurotrophin-3 modulates breast cancer cells and the microenvironment to promote the growth of breast cancer brain metastasis, Oncogene, 32(35), 4064-4077. doi:10.1038/onc.2012.417 [doi]
Shoshani, O., Massalha, H., Shani, N., Kagan, S., Ravid, O., Madar, S., . . . Zipori, D. (2012)., Polyploidization of murine mesenchymal cells is associated with suppression of the long noncoding RNA H19 and reduced tumorigenicity., Cancer Research, 72(24), 6403-6413. doi:10.1158/0008-5472.CAN-12-1155 [doi]
Talarico, C., D'Antona, L., Scumaci, D., Barone, A., Gigliotti, F., Fiumara, C. V., . . . Amato, R. (2015)., Preclinical model in HCC: The SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy, Oncotarget, 6(35), 37511-37525. doi:10.18632/oncotarget.5527 [doi]
Stamatakis, K., Jimenez-Martinez, M., Jimenez-Segovia, A., Chico-Calero, I., Conde, E., Galan-Martinez, J., . . . Fresno, M. (2015)., Prostaglandins induce early growth response 1 transcription factor mediated microsomal prostaglandin E2 synthase up-regulation for colorectal cancer progression., Oncotarget, 6(37), 39941-39959. doi:10.18632/oncotarget.5402 [doi]
Quesada, Mari Paz; García-Bernal, David; Pastor, Diego; Estirado, Alicia; Blanquer, Miguel; García-Hernández, Ana M; Moraleda, José M, Martínez, Salvador;, Safety and Biodistribution of Human Bone Marrow-Derived Mesenchymal Stromal Cells Injected Intrathecally in Non-Obese Diabetic Severe Combined Immunodeficiency Mice: Preclinical Study., Tissue engineering and regenerative medicine Vol.16, 2019
Dattilo, V., D'Antona, L., Talarico, C., Capula, M., Catalogna, G., Iuliano, R., . . . Amato, R. (2017)., SGK1 affects RAN/RANBP1/RANGAP1 via SP1 to play a critical role in pre-miRNA nuclear export: A new route of epigenomic regulation, Scientific Reports, 7, 45361. doi:10.1038/srep45361 [doi]
Gudlevičienė Z, Žilinskas K, Kundrotas G, Grubliauskaitė M, Baltriukienė D, Bukelskienė V., Slow-Freezing Cryopreservation Ensures High Ovarian Tissue Quality Followed by In Vivo and In Vitro Methods and Is Safe for Fertility Preservation, Medicina (Kaunas). 2020 Oct 19;56(10):547. doi: 10.3390/medicina56100547.
Terrasi, Andrea; Bertolini, Irene; Martelli, Cristina; Gaudioso, Gabriella; Di Cristofori, Andrea; Storaci, Alessandra Maria; Formica, Miriam; Bosari, Silvano; Caroli, Manuela; Ottobrini, Luisa; Vaccari, Thomas; Vaira, Valentina;, Specific V-ATPase expression sub-classifies IDHwt lower-grade gliomas and impacts glioma growth in vivo., EBioMedicine Vol.41, 2019
Levy, L., Mishalian, I., Bayuch, R., Zolotarov, L., Michaeli, J., & Fridlender, Z. G. (2015)., Splenectomy inhibits non-small cell lung cancer growth by modulating anti-tumor adaptive and innate immune response., Oncoimmunology, 4(4), e998469. doi:10.1080/2162402X.2014.998469 [doi]
Sage, E. K., Kolluri, K. K., McNulty, K., Lourenco Sda, S., Kalber, T. L., Ordidge, K. L., . . . Janes, S. M. (2014)., Systemic but not topical TRAIL-expressing mesenchymal stem cells reduce tumour growth in malignant mesothelioma., Thorax, 69(7), 638-647. doi:10.1136/thoraxjnl-2013-204110 [doi]
Song, W., Hwang, Y., Youngblood, V. M., Cook, R. S., Balko, J. M., Chen, J., & Brantley-Sieders, D. M. (2017), Targeting EphA2 impairs cell cycle progression and growth of basal-like/triple-negative breast cancers., Oncogene, 36(40), 5620-5630. doi:10.1038/onc.2017.170 [doi]
Stivarou, T., Stellas, D., Vartzi, G., Thomaidou, D., & Patsavoudi, E. (2016)., Targeting highly expressed extracellular HSP90 in breast cancer stem cells inhibits tumor growth in vitro and in vivo, Cancer Biology & Therapy, 17(8), 799-812. doi:10.1080/15384047.2016.1195041 [doi]
Woosley, Alec N; Dalton, Annamarie C; Hussey, George S; Howley, Breege V; Mohanty, Bidyut K; Grelet, Simon; Dincman, Toros; Bloos, Sean; Olsen, Shaun K; Howe, Philip H;, TGFβ promotes breast cancer stem cell self-renewal through an ILEI/LIFR signaling axis, Oncogene Vol.38, 2019
Sukowati, C. H., Anfuso, B., Torre, G., Francalanci, P., Croce, L. S., & Tiribelli, C. (2013), The expression of CD90/Thy-1 in hepatocellular carcinoma: An in vivo and in vitro study, PloS One, 8(10), e76830. doi:10.1371/journal.pone.0076830 [doi]
Mathieu, M. G., Miles, A. K., Ahmad, M., Buczek, M. E., Pockley, A. G., Rees, R. C., & Regad, T. (2014), The helicase HAGE prevents interferon-alpha-induced PML expression in ABCB5+ malignant melanoma-initiating cells by promoting the expression of SOCS1, Cell Death & Disease, 5, e1061. doi:10.1038/cddis.2014.29 [doi]
Fareh, M., Turchi, L., Virolle, V., Debruyne, D., Almairac, F., de-la-Forest Divonne, S., . . . Virolle, T. (2012)., The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network, Cell Death and Differentiation, 19(2), 232-244. doi:10.1038/cdd.2011.89 [doi]
Shetzer, Y., Kagan, S., Koifman, G., Sarig, R., Kogan-Sakin, I., Charni, M., . . . Aloni-Grinstein, R. (2014)., The onset of p53 loss of heterozygosity is differentially induced in various stem cell types and may involve the loss of either allele., Cell Death and Differentiation, 21(9), 1419-1431. doi:10.1038/cdd.2014.57 [doi]
Sukowati, C. H., Anfuso, B., Croce, L. S., & Tiribelli, C. (2015)., The role of multipotent cancer associated fibroblasts in hepatocarcinogenesis, BMC Cancer, 15, 188-015-1196-y. doi:10.1186/s12885-015-1196-y [doi]
Boesch, M., Zeimet, A. G., Reimer, D., Schmidt, S., Gastl, G., Parson, W., . . . Sopper, S. (2014)., The side population of ovarian cancer cells defines a heterogeneous compartment exhibiting stem cell characteristics., Oncotarget, 5(16), 7027-7039. doi:2053 [pii]
Ghosh, Susmita; Prasad, Manu; Kundu, Kiran; Cohen, Limor; Yegodayev, Ksenia M; Zorea, Jonathan; Joshua, Ben-Zion; Lasry, Batel; Dimitstein, Orr; Bahat-Dinur, Anat; Mizrachi, Aviram; Lazar, Vladimir; Elkabets, Moshe; Porgador, Angel;, Tumor Tissue Explant Culture of Patient-Derived Xenograft as Potential Prioritization Tool for Targeted Therapy, Frontiers in oncology Vol.9, 2019
Turchi, L., Debruyne, D. N., Almairac, F., Virolle, V., Fareh, M., Neirijnck, Y., . . . Virolle, T. (2013), Tumorigenic potential of miR-18A* in glioma initiating cells requires NOTCH-1 signaling, Stem Cells (Dayton, Ohio), 31(7), 1252-1265. doi:10.1002/stem.1373 [doi]
Ron, Avihai; Deán-Ben,Xosé Luís; Gottschalk, Sven; Razansky, Daniel;, Volumetric Optoacoustic Imaging Unveils High-Resolution Patterns of Acute and Cyclic Hypoxia in a Murine Model of Breast Cancer., Cancer research Vol.79, 2019
Qureshi-Baig, K., Ullmann, P., Rodriguez, F., Frasquilho, S., Nazarov, P. V., Haan, S., & Letellier, E. (2016)., What do we learn from spheroid culture systems? insights from tumorspheres derived from primary colon cancer tissue., PloS One, 11(1), e0146052. doi:10.1371/journal.pone.0146052 [doi]

Subscribe to updates from Inotiv

Sign up and you’ll receive the latest updates that matter to you, delivered straight to your inbox.

Subscribe now