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    Cellular therapies

    Nowak-Imialek M, Wunderlich S, Herrmann D, Breitschuh-Leibling S, Gohring G, Petersen B, Klein S, Baulain U, Lucas-Hahn A, Martin U, Niemann H., In Vitro and In Vivo Interspecies Chimera Assay Using Early Pig Embryos, Cell Reprogram. 2020 Jun;22(3):118-133. doi: 10.1089/cell.2019.0107. Epub 2020 May 19.

    COVID-19

    Finch CL, Crozier I, Lee JH, Byrum R, Cooper TK, Liang J, Sharer K, Solomon J, Sayre PJ, Kocher G, Bartos C, Aiosa NM, Castro M, Larson PA, Adams R, Beitzel B, Di Paola N, Kugelman JR, Kurtz JR, Burdette T, Nason MC, Feuerstein IM, Palacios G, St Claire MC, Lackemeyer MG, Johnson RF, Braun KM, Ramuta MD, Wada J, Schmaljohn CS, Friedrich TC, O'Connor DH, Kuhn JH., Characteristic and quantifiable COVID-19-like abnormalities in CT- and PET/CT-imaged lungs of SARS-CoV-2-infected crab-eating macaques (Macaca fascicularis), bioRxiv. 2020 May 14:2020.05.14.096727. doi: 10.1101/2020.05.14.096727. Preprint.
    Baisa G, Rancour D, Mansfield K, Burns M, Martin L, Cunha D, Fischer J, Muecksch F, Hatziioannou T, Bieniasz P, Schomburg F, Luke K., A recombinant protein SARS-CoV-2 candidate vaccine elicits high-titer neutralizing antibodies in macaques, bioRxiv. 2020 Dec 21:2020.12.20.422693. doi: 10.1101/2020.12.20.422693. Preprint.

    Diabetes

    Vahle, John L; Byrd, Richard A; Blackbourne, Jamie L; Martin, Jennifer A; Sorden, Steven D; Ryan, Thomas; Pienkowski, Thomas; Rosol, Thomas J; Snyder, Paul W; Klöppel, Günter;, Effects of the GLP-1 Receptor Agonist Dulaglutide on the Structure of the Exocrine Pancreas of Cynomolgus Monkeys., Toxicologic pathology Vol.43, 2015
    Levy, Odile E; Jodka, Carolyn M; Ren, Shijun Steven; Mamedova, Lala; Sharma, Abhinandini; Samant, Manoj; DSouza, Lawrence J; Soares, Christopher J; Yuskin, Diane R; Jin, Li Jenny; Parkes, David G; Tatarkiewicz, Krystyna; Ghosh, Soumitra S, Novel exenatide analogs with peptidic albumin binding domains: potent anti-diabetic agents with extended duration of action., PloS one Vol.9, 2014
    Kolumam, Ganesh; Chen, Mark Z; Tong, Raymond; Zavala-Solorio, Jose; Kates, Lance; van Bruggen, Nicholas; Ross, Jed; Wyatt, Shelby K; Gandham, Vineela D; Carano, Richard A D; Dunshee, Diana Ronai; Wu, Ai-Luen; Haley, Benjamin; Anderson, Keith; Warming, Søren; Rairdan, Xin Y; Lewin-Koh, Nicholas; Zhang, Yingnan; Gutierrez, Johnny; Baruch, Amos; Gelzleichter, Thomas R; Stevens, Dale; Rajan, Sharmila; Bainbridge, Travis W; Vernes, Jean-Michel; Meng, Y Gloria; Ziai, James; Soriano, Robert H; Brauer, Matthew J; Chen, Yongmei; Stawicki, Scott; Kim, Hok Seon; Comps-Agrar, Laëtitia; Luis, Elizabeth; Spiess, Christoph; Wu, Yan; Ernst, James A; McGuinness, Owen P; Peterson, Andrew S; Sonoda, Junichiro;, Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/?Klotho Complex, EBioMedicine Vol.2, 2015

    General studies

    Le, Kha N; Gibiansky, Leonid; Good, Jeremy; Davancaze, Teresa; van Lookeren Campagne, Menno; Loyet, Kelly M; Morimoto, Alyssa; Jin, Jin; Damico-Beyer, Lisa A; Hanley, William D;, A mechanistic pharmacokinetic/pharmacodynamic model of factor D inhibition in cynomolgus monkeys by lampalizumab for the treatment of geographic atrophy., The Journal of pharmacology and experimental therapeutics Vol.355, 2015
    Datta-Mannan, Amita; Croy, Johnny E; Schirtzinger, Linda; Torgerson, Stacy; Breyer, Matthew; Wroblewski, Victor J;, Aberrant bispecific antibody pharmacokinetics linked to liver sinusoidal endothelium clearance mechanism in cynomolgus monkeys, mAbs Vol.8, 2016
    Heyen, Jonathan R; Rojko, Jennifer; Evans, Mark; Brown, Tom P; Bobrowski, Walter F; Vitsky, Allison; Dalton, Shana; Tripathi, Niraj; Bollini, Sangeetha Subbarao; Johnson, Theodore; Lin, John C; Khan, Nasir; Han, Bora;, Characterization, biomarkers, and reversibility of a monoclonal antibody-induced immune complex disease in cynomolgus monkeys (Macaca fascicularis)., Toxicologic pathology Vol.42, 2014
    Cirimotich, Chris M; Vela, Eric M; Garver, Jennifer; Barnewall, Roy E; Miller, Brian D; Meister, Gabriel T; Rogers, James V;, Chikungunya virus infection in Cynomolgus macaques following Intradermal and aerosol exposure., Virology journal Vol.14, 2017
    Grant-Klein, Rebecca J; Altamura, Louis A; Badger, Catherine V; Bounds, Callie E; Van Deusen, Nicole M; Kwilas, Steven A; Vu, Hong A; Warfield, Kelly L; Hooper, Jay W; Hannaman, Drew; Dupuy, Lesley C; Schmaljohn, Connie S;, Codon-optimized filovirus DNA vaccines delivered by intramuscular electroporation protect cynomolgus macaques from lethal Ebola and Marburg virus challenges., Human vaccines & immunotherapeutics Vol.11, 2015
    Bantseev, Vladimir; Miller, Paul E; Nork, T Michael; Rasmussen, Carol A; McKenzie, Aija; Christian, Brian J; Booler, Helen; Thackaberry, Evan A;, Determination of a No Observable Effect Level for Endotoxin Following a Single Intravitreal Administration to Cynomolgus Monkeys., Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics Vol.35, 2019
    Phuah, Jiayao; Wong, Eileen A; Gideon, Hannah P; Maiello, Pauline; Coleman, M Teresa; Hendricks, Matthew R; Ruden, Rachel; Cirrincione, Lauren R; Chan, John; Lin, Philana Ling; Flynn, JoAnne L;, Effects of B Cell Depletion on Early Mycobacterium tuberculosis Infection in Cynomolgus Macaques., Infection and immunity Vol.84, 2016
    Malkevich, Nina V; Hopkins, Robert J; Bernton, Edward; Meister, Gabriel T; Vela, Eric M; Atiee, George; Johnson, Virginia; Nabors, Gary S; Aimes, Ronald T; Ionin, Boris; Skiadopoulos, Mario H;, Efficacy and safety of AVP-21D9, an anthrax monoclonal antibody, in animal models and humans., . Antimicrobial agents and chemotherapy Vol.58, 2014
    Dunshee, Diana Ronai; Bainbridge, Travis W; Kljavin, Noelyn M; Zavala-Solorio, Jose; Schroeder, Amy C; Chan, Ruby; Corpuz, Racquel; Wong, Manda; Zhou, Wei; Deshmukh, Gauri; Ly, Justin; Sutherlin, Daniel P; Ernst, James A; Sonoda, Junichiro;, Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21., The Journal of biological chemistry Vol.291, 2016
    Husar, Elisabeth; Solonets, Maria; Kuhlmann, Olaf; Schick, Eginhard; Piper-Lepoutre, Hanna; Singer, Thomas; Tyagi, Gaurav;, Hypersensitivity Reactions to Obinutuzumab in Cynomolgus Monkeys and Relevance to Humans., Toxicologic pathology Vol.45, 2017
    Hutt, Julie A; Lovchik, Julie A; Drysdale, Melissa; Sherwood, Robert L; Brasel, Trevor; Lipscomb, Mary F; Lyons, C Rick;, Lethal factor, but not edema factor, is required to cause fatal anthrax in cynomolgus macaques after pulmonary spore challenge., The American journal of pathology Vol.184, 2014
    Quinet, Elaine M; Basso, Michael D; Halpern, Anita R; Yates, David W; Steffan, Robert J; Clerin, Valerie; Resmini, Christine; Keith, James C; Berrodin, Thomas J; Feingold, Irene; Zhong, Wenyan; Hartman, Helen B; Evans, Mark J; Gardell, Stephen J; DiBlasio-Smith, Elizabeth; Mounts, William M; LaVallie, Edward R; Wrobel, Jay; Nambi, Ponnal; Vlasuk, George P, LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse., Journal of lipid research Vol.50, 2009
    Alfson, Kendra J; Avena, Laura E; Beadles, Michael W; Staples, Hilary; Nunneley, Jerritt W; Ticer, Anysha; Dick, Edward J; Owston, Michael A; Reed, Christopher; Patterson, Jean L; Carrion, Ricardo; Griffiths, Anthony;, Particle-to-PFU ratio of Ebola virus influences disease course and survival in cynomolgus macaques, Journal of virology Vol.89, 2015
    Mitchell, Andrea Z; McMahon, Carrie; Beck, Tom W; Sarazan, R Dustan, Sensitivity of two noninvasive blood pressure measurement techniques compared to telemetry in cynomolgus monkeys and beagle dogs, Journal of pharmacological and toxicological methods Vol.62,
    Buse, Eberhard; Häeger, Jan-Dirk; Svensson-Arvelund, Judit; Markert, Udo R; Faas, Marijke M; Ernerudh, Jan; Dixon, Darlene; Cline, J Mark; Pfarrer, Christiane;, The placenta in toxicology. Part I: Animal models in toxicology: placental morphology and tolerance molecules in the cynomolgus monkey (Macaca fascicularis)., Toxicologic pathology Vol.42, 2014
    Hoffmann, Peter; Bentley, Phil; Sahota, Pritam; Schoenfeld, Heidi; Martin, Lori; Longo, Linda; Spaet, Robert; Moulin, Pierre; Pantano, Serafino; Dubost, Valerie; Lapadula, Dan; Burkey, Bryan; Kaushik, Virendar; Zhou, Wei; Hayes, Michael; Flavahan, Nick; Chibout, Salah-Dine; Busch, Steve;, Vascular origin of vildagliptin-induced skin effects in Cynomolgus monkeys: pathomechanistic role of peripheral sympathetic system and neuropeptide Y, Toxicologic pathology Vol.42, 2014

    Immunology

    Vitale LA, He LZ, Thomas LJ, Wasiuk A, O'Neill T, Widger J, Crocker A, Mills-Chen L, Forsberg E, Weidlick J, Patterson C, Hammond RA, Boyer J, Sisson C, Alvarado D, Goldstein J, Marsh HC Jr, Keler T., Development of CDX-527: a bispecific antibody combining PD-1 blockade and CD27 costimulation for cancer immunotherapy, Cancer Immunol Immunother. 2020 Oct;69(10):2125-2137. doi: 10.1007/s00262-020-02610-y. Epub 2020 May 25.
    Sivko, G S; Stark, G V; Tordoff, K P; Taylor, K L; Glaze, E; VanRaden, M; Schiffer, J M; Hewitt, J A; Quinn, C P; Nuzum, E O;, Evaluation of early immune response-survival relationship in cynomolgus macaques after Anthrax Vaccine Adsorbed vaccination and Bacillus anthracis spore challenge, Vaccine Vol.34, 2016
    Latuszek A, Liu Y, Olsen O, Foster R, Cao M, Lovric I, Yuan M, Liu N, Chen H, Zhang Q, Xiao H, Springer C, Ehrlich G, Kamat V, Rafique A, Hu Y, Krueger P, Huang T, Poueymirou W, Babb R, Rosconi MP, Retter MW, Chen G, Morton L, Zambrowicz B, Cao J, Romano C, Olson WC., Inhibition of complement pathway activation with Pozelimab, a fully human antibody to complement component C5, PLoS One. 2020 May 8;15(5):e0231892. doi: 10.1371/journal.pone.0231892. eCollection 2020.
    Gideon, Hannah P; Phuah, Jiayao; Junecko, Beth A; Mattila, Joshua T;, Neutrophils express pro- and anti-inflammatory cytokines in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques., Mucosal immunology Vol.12, 2019
    Dheilly, Elie; Moine, Valéry; Broyer, Lucile; Salgado-Pires, Susana; Johnson, Zoë; Papaioannou, Anne; Cons, Laura; Calloud, Sébastien; Majocchi, Stefano; Nelson, Robert; Rousseau, François; Ferlin, Walter; Kosco-Vilbois, Marie; Fischer, Nicolas; Masternak, Krzysztof;, Selective Blockade of the Ubiquitous Checkpoint Receptor CD47 Is Enabled by Dual-Targeting Bispecific Antibodies., Molecular therapy : the journal of the American Society of Gene Therapy Vol.25, 2017

    Infectious disease

    Baisa G, Rancour D, Mansfield K, Burns M, Martin L, Cunha D, Fischer J, Muecksch F, Hatziioannou T, Bieniasz P, Schomburg F, Luke K., A recombinant protein SARS-CoV-2 candidate vaccine elicits high-titer neutralizing antibodies in macaques, bioRxiv. 2020 Dec 21:2020.12.20.422693. doi: 10.1101/2020.12.20.422693. Preprint.
    Finch CL, Crozier I, Lee JH, Byrum R, Cooper TK, Liang J, Sharer K, Solomon J, Sayre PJ, Kocher G, Bartos C, Aiosa NM, Castro M, Larson PA, Adams R, Beitzel B, Di Paola N, Kugelman JR, Kurtz JR, Burdette T, Nason MC, Feuerstein IM, Palacios G, St Claire MC, Lackemeyer MG, Johnson RF, Braun KM, Ramuta MD, Wada J, Schmaljohn CS, Friedrich TC, O'Connor DH, Kuhn JH., Characteristic and quantifiable COVID-19-like abnormalities in CT- and PET/CT-imaged lungs of SARS-CoV-2-infected crab-eating macaques (Macaca fascicularis), bioRxiv. 2020 May 14:2020.05.14.096727. doi: 10.1101/2020.05.14.096727. Preprint.

    Neuroscience

    Takemura H, Palomero-Gallagher N, Axer M, Gräßel D, Jorgensen MJ, Woods R, Zilles K., Anatomy of nerve fiber bundles at micrometer-resolution in the vervet monkey visual system, Elife. 2020 Aug 26;9:e55444. doi: 10.7554/eLife.55444.
    Niu M, Impieri D, Rapan L, Funck T, Palomero-Gallagher N, Zilles K., Receptor-driven, multimodal mapping of cortical areas in the macaque monkey intraparietal sulcus, Elife. 2020 Jul 2;9:e55979. doi: 10.7554/eLife.55979.

    Obesity

    Yang, Linda; Chang, Chih-Chuan; Sun, Zhe; Madsen, Dennis; Zhu, Haisun; Padkjær, Søren B; Wu, Xiaoai; Huang, Tao; Hultman, Karin; Paulsen, Sarah J; Wang, Jishu; Bugge, Anne; Frantzen, Jane Boesen; Nørgaard, Per; Jeppesen, Jacob Fuglsbjerg; Yang, Zhiru; Secher, Anna; Chen, Haibin; Li, Xun; John, Linu Mary; Shan, Bing; He, Zhenhua; Gao, Xiang; Su, Jing; Hansen, Kristian T; Yang, Wei; Jørgensen, Sebastian Beck;, GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand., Nature medicine Vol.23, 2017

    Pharmacology

    St Andre, Michael; Johnson, Mark; Bansal, Prashant N; Wellen, Jeremy; Robertson, Andrew; Opsahl, Alan; Burch, Peter M; Bialek, Peter; Morris, Carl;, A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys, Skeletal muscle Vol.7, 2017
    Barfield RM, Kim YC, Chuprakov S, Zhang F, Bauzon M, Ogunkoya AO, Yeo D, Hickle C, Pegram MD, Rabuka D, Drake PM., A Novel HER2-targeted Antibody-drug Conjugate Offers the Possibility of Clinical Dosing at Trastuzumab-equivalent Exposure Levels, Mol Cancer Ther. 2020 Sep;19(9):1866-1874. doi: 10.1158/1535-7163.MCT-20-0190. Epub 2020 Jul 10.
    Smith, Eric J; Olson, Kara; Haber, Lauric J; Varghese, Bindu; Duramad, Paurene; Tustian, Andrew D; Oyejide, Adelekan; Kirshner, Jessica R; Canova, Lauren; Menon, Jayanthi; Principio, Jennifer; MacDonald, Douglas; Kantrowitz, Joel; Papadopoulos, Nicholas; Stahl, Neil; Yancopoulos, George D; Thurston, Gavin; Davis, Samuel;, A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys., Scientific reports Vol.5, 2015
    Elliott AG, Huang JX, Neve S, Zuegg J, Edwards IA, Cain AK, Boinett CJ, Barquist L, Lundberg CV, Steen J, Butler MS, Mobli M, Porter KM, Blaskovich MAT, Lociuro S, Strandh M, Cooper MA., An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria, Nat Commun. 2020 Jun 23;11(1):3184. doi: 10.1038/s41467-020-16950-x.
    Sainson RCA, Thotakura AK, Kosmac M, Borhis G, Parveen N, Kimber R, Carvalho J, Henderson SJ, Pryke KL, Okell T, O'Leary S, Ball S, Van Krinks C, Gamand L, Taggart E, Pring EJ, Ali H, Craig H, Wong VWY, Liang Q, Rowlands RJ, Lecointre M, Campbell J, Kirby I, Melvin D, Germaschewski V, Oelmann E, Quaratino S, McCourt M., An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression, Cancer Immunol Res. 2020 Dec;8(12):1568-1582. doi: 10.1158/2326-6066.CIR-20-0034. Epub 2020 Sep 30.
    Nagy CF, Mondick J, Serbina N, Casey LS, Carpenter SE, French J, Guttendorf R., Animal-to-Human Dose Translation of Obiltoxaximab for Treatment of Inhalational Anthrax Under the US FDA Animal Rule., Clin Transl Sci. 2017 Jan;10(1):12-19.
    Carter QL, Siegel RW, Qian Y, Konrad RJ., Application of a novel drug-tolerant target assay for measuring target engagement when only one epitope remains after therapeutic antibodies bind their targets, J Immunol Methods. 2021 Feb;489:112916. doi: 10.1016/j.jim.2020.112916. Epub 2020 Nov 23.
    Lin, Cheng-Wen; Sherman, Bryan; Moore, Lori A; Laethem, Carmen L; Lu, Da-Wen; Pattabiraman, Padmanabhan P; Rao, Ponugoti Vasantha; deLong, Mitchell A; Kopczynski, Casey C;, Discovery and Preclinical Development of Netarsudil, a Novel Ocular Hypotensive Agent for the Treatment of Glaucoma., Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics Vol.34,
    Shen J, Moats RA, Pollack HA, Robinson MR, Attar M., Distribution of (14)C-Latanoprost Following a Single Intracameral Administration Versus Repeated Topical Administration, Ophthalmol Ther. 2020 Dec;9(4):929-940. doi: 10.1007/s40123-020-00285-3. Epub 2020 Aug 1.
    Vahle, John L; Byrd, Richard A; Blackbourne, Jamie L; Martin, Jennifer A; Sorden, Steven D; Ryan, Thomas; Pienkowski, Thomas; Wijsman, John A; Smith, Holly W; Rosol, Thomas J;, Effects of Dulaglutide on Thyroid C Cells and Serum Calcitonin in Male Monkeys, Endocrinology Vol.156, 2015
    Russo, Andrew T; Grosenbach, Douglas W; Brasel, Trevor L; Baker, Robert O; Cawthon, Andrew G; Reynolds, Erin; Bailey, Tara; Kuehl, Philip J; Sugita, Victoria; Agans, Krystle; Hruby, Dennis E;, Effects of Treatment Delay on Efficacy of Tecovirimat Following Lethal Aerosol Monkeypox Virus Challenge in Cynomolgus Macaques., The Journal of infectious diseases Vol.218, 2018
    Shearer JD, Henning L, Sanford DC, Li N, Skiadopoulos MH, Reece JJ, Ionin B, Savransky V., Efficacy of the AV7909 anthrax vaccine candidate in guinea pigs and nonhuman primates following two immunizations two weeks apart, Vaccine. 2021 Jan 3;39(1):1-5. doi: 10.1016/j.vaccine.2020.10.095. Epub 2020 Nov 13.
    Yamamoto BJ, Shadiack AM, Carpenter S, Sanford D, Henning LN, O'Connor E, Gonzales N, Mondick J, French J, Stark GV, Fisher AC, Casey LS, Serbina NV., Efficacy Projection of Obiltoxaximab for Treatment of Inhalational Anthrax across a Range of Disease Severity. Antimicrob Agents Chemother., 2016 Sep 23;60(10):5787-95.
    Frederick A, Sullivan J, Liu L, Adamowicz M, Lukason M, Raymer J, Luo Z, Jin X, Rao KN, O'Riordan C., Engineered Capsids for Efficient Gene Delivery to the Retina and Cornea, Hum Gene Ther. 2020 Jul;31(13-14):756-774. doi: 10.1089/hum.2020.070.
    Almholt K, Wang J, Pass J, Røder G, Padkjær SB, Hebsgaard JB, Xia W, Yang L, Forsell J, Breinholt VM, Thygesen P, Agersø H, Loftager M, Usher PA., Identification and preclinical development of an anti-proteolytic uPA antibody for rheumatoid arthritis, J Mol Med (Berl). 2020 Apr;98(4):585-593. doi: 10.1007/s00109-020-01889-9. Epub 2020 Feb 27.
    Laffan SB, Thomson AS, Mai S, Fishman C, Kambara T, Nistala K, Raymond JT, Chen S, Ramani T, Pageon L, Polsky R, Watkins M, Ottolangui G, White JR, Maier C, Herdman M, Bouma G., Immune complex disease in a chronic monkey study with a humanised, therapeutic antibody against CCL20 is associated with complement-containing drug aggregates, PLoS One. 2020 Apr 23;15(4):e0231655. doi: 10.1371/journal.pone.0231655. eCollection 2020.
    Damann N, Bahrenberg G, Stockhausen H, Habermann CJ, Lesch B, Frank-Foltyn R, Lee J, Ann J, Christoph T., In vitro characterization of the thermoneutral transient receptor potential vanilloid-1 (TRPV1) inhibitor GRTE16523, Eur J Pharmacol. 2020 Mar 15;871:172934. doi: 10.1016/j.ejphar.2020.172934. Epub 2020 Jan 16.
    Lawrence SA, Blankenship R, Brown R, Estwick S, Ellis B, Thangaraju A, Datta-Mannan A., Influence of FcRn binding properties on the gastrointestinal absorption and exposure profile of Fc molecules, Bioorg Med Chem. 2020 Dec 21;32:115942. doi: 10.1016/j.bmc.2020.115942. Online ahead of print.
    Datta-Mannan A, Estwick S, Zhou C, Choi H, Douglass NE, Witcher DR, Lu J, Beidler C, Millican R., Influence of physiochemical properties on the subcutaneous absorption and bioavailability of monoclonal antibodies, MAbs. 2020 Jan 1;12(1):1770028. doi: 10.1080/19420862.2020.1770028.
    Bennett G, Brown A, Mudd G, Huxley P, Van Rietschoten K, Pavan S, Chen L, Watcham S, Lahdenranta J, Keen N., MMAE Delivery Using the Bicycle Toxin Conjugate BT5528, Mol Cancer Ther. 2020 Jul;19(7):1385-1394. doi: 10.1158/1535-7163.MCT-19-1092. Epub 2020 May 12.
    Del Balzo U, Signore PE, Walkinshaw G, Seeley TW, Brenner MC, Wang Q, Guo G, Arend MP, Flippin LA, Chow FA, Gervasi DC, Kjaergaard CH, Langsetmo I, Guenzler V, Liu DY, Klaus SJ, Lin A, Neff TB., Nonclinical Characterization of the Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat, a Novel Treatment of Anemia of Chronic Kidney Disease, J Pharmacol Exp Ther. 2020 Aug;374(2):342-353. doi: 10.1124/jpet.120.265181. Epub 2020 Jun 2.
    Yamamoto BJ, Shadiack AM, Carpenter S, Sanford D, Henning LN, Gonzales N, O'Connor E, Casey LS, Serbina NV, Obiltoxaximab Prevents Disseminated Bacillus anthracis Infection and Improves Survival during Pre- and Postexposure Prophylaxis in Animal Models of Inhalational Anthrax., Antimicrob Agents Chemother. 2016 Sep 23;60(10):5796-805.
    Tess DA, Eng H, Kalgutkar AS, Litchfield J, Edmonds DJ, Griffith DA, Varma MVS., Predicting the Human Hepatic Clearance of Acidic and Zwitterionic Drugs, J Med Chem. 2020 Oct 22;63(20):11831-11844. doi: 10.1021/acs.jmedchem.0c01033. Epub 2020 Oct 9.
    Randolph JT, Voight EA, Greszler SN, Uno BE, Newton JN, Gleason KM, Stolarik D, Van Handel C, Bow DAJ, DeGoey DA., Prodrug Strategies to Improve the Solubility of the HCV NS5A Inhibitor Pibrentasvir (ABT-530), J Med Chem. 2020 Oct 8;63(19):11034-11044. doi: 10.1021/acs.jmedchem.0c00956. Epub 2020 Sep 17.
    Liu J, Xavy S, Mihardja S, Chen S, Sompalli K, Feng D, Choi T, Agoram B, Majeti R, Weissman IL, Volkmer JP., Targeting macrophage checkpoint inhibitor SIRPα for anticancer therapy, JCI Insight. 2020 Jun 18;5(12):e134728. doi: 10.1172/jci.insight.134728.
    Kovalova N, Boyles J, Wen Y, Witcher DR, Brown-Augsburger PL, Wroblewski VJ, Chlewicki LK., Validation of a de-immunization strategy for monoclonal antibodies using cynomolgus macaque as a surrogate for human, Biopharm Drug Dispos. 2020 Mar;41(3):111-125. doi: 10.1002/bdd.2222. Epub 2020 Mar 10.
    Walgren, Jennie L; Carfagna, Mark A; Koger, Deanna; Sgro, Mario; Kallman, Mary Jeanne;, Withdrawal assessment following subchronic oral ketamine administration in Cynomolgus macaques., Drug development research Vol.75, 2014

    Toxicology

    Hordeaux J, Buza EL, Dyer C, Goode T, Mitchell TW, Richman L, Denton N, Hinderer C, Katz N, Schmid R, Miller R, Choudhury GR, Horiuchi M, Nambiar K, Yan H, Li M, Wilson JM., Adeno-Associated Virus-Induced Dorsal Root Ganglion Pathology, Hum Gene Ther. 2020 Aug;31(15-16):808-818. doi: 10.1089/hum.2020.167. Epub 2020 Jul 31.
    Obert LA, Suttie A, Abdi M, Gales T, Dwyer D, Fritz W, Robertson N, Weir L, Frazier K., Congenital Unilateral Renal Aplasia in a Cynomolgus Monkey (Macaca fascicularis) With Investigation Into Potential Pathogenesis, Toxicol Pathol. 2020 Aug;48(6):766-783. doi: 10.1177/0192623320941834. Epub 2020 Aug 20.
    Grossmann H, Weinbauer GF, Baker A, Fuchs A, Luetjens CM., Enhanced normograms and pregnancy outcome analysis in nonhuman primate developmental toxicity studies, Reprod Toxicol. 2020 Aug;95:29-36. doi: 10.1016/j.reprotox.2020.04.074. Epub 2020 May 13.
    Luetjens CM, Fuchs A, Baker A, Weinbauer GF., Group size experiences with enhanced pre- and postnatal development studies in the long-tailed macaque (Macaca fascicularis), Primate Biol. 2020 Mar 11;7(1):1-4. doi: 10.5194/pb-7-1-2020. eCollection 2020.
    Zinn, Kurt R; Korb, Melissa; Samuel, Sharon; Warram, Jason M; Dion, David; Killingsworth, Cheryl; Fan, Jinda; Schoeb, Trenton; Strong, Theresa V; Rosenthal, Eben L;, IND-directed safety and biodistribution study of intravenously injected cetuximab-IRDye800 in cynomolgus macaques., Molecular imaging and biology Vol.17, 2015
    Laing ST, Bockenstedt MM, Booler HS., Inflammation of a Posterior Ciliary Artery in a Naive Cynomolgus Macaque, Toxicol Pathol. 2020 Aug 28:192623320952337. doi: 10.1177/0192623320952337. Online ahead of print.
    Andaya R, Booler H, Nagata DA, Lawson C, Vogt J, Schuetz C, Chang DP, Bantseev V., Intravitreal Administration of Acetyl Triethyl Citrate and Benzyl Benzoate Is Retinotoxic in Rabbits but Not in Cynomolgus Monkeys, Toxicol Pathol. 2020 Nov 28:192623320971571. doi: 10.1177/0192623320971571. Online ahead of print.
    Schultze, Albert Eric; Anderson, Jason M; Kern, Tom G; Justus, Ryan W; Lee, Hsiu-Yung Cindy; Zieske, Lynn R; Goodson, Robert James; Florey, Sara Hudson;, Longitudinal studies of cardiac troponin I concentrations in serum from male cynomolgus monkeys: resting values and effects of oral and intravenous dosing on biologic variability., Veterinary clinical pathology Vol.44, 2015
    Baptista MAS, Merchant K, Barrett T, Bhargava S, Bryce DK, Ellis JM, Estrada AA, Fell MJ, Fiske BK, Fuji RN, Galatsis P, Henry AG, Hill S, Hirst W, Houle C, Kennedy ME, Liu X, Maddess ML, Markgraf C, Mei H, Meier WA, Needle E, Ploch S, Royer C, Rudolph K, Sharma AK, Stepan A, Steyn S, Trost C, Yin Z, Yu H, Wang X, Sherer TB., LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits, Sci Transl Med. 2020 Apr 22;12(540):eaav0820. doi: 10.1126/scitranslmed.aav0820.
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