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Envigo Horizon infographic

The announced transaction between Envigo and Horizon is complete.

Envigo RMS LLC (“Envigo”), a leading global supplier of research models and associated services has acquired the assets of the research models business unit of Horizon Discovery Group plc (“Horizon”, LSE:HZD).

Horizon’s research models business unit, which provides genetically engineered models from its premises in Boyertown, Pennsylvania and St Louis, Missouri, USA, has been transferred to Envigo ownership, including assets and employees. The business unit uses Horizon’s gene editing expertise to produce customized models with clinically relevant gene deletions, insertions and other modifications, which are then used as pre-clinical models for human disease during drug discovery and development. The two companies will collaborate to ensure continuity and enable all customers to access CRISPR-edited research models for screening and other applications.

Envigo, which is headquartered in the US, has more than 1,200 employees in more than 20 locations across North America and Europe, and is a market-leading provider of a broad range of standard research models to the pharmaceutical and biotechnology industries, government, academia and other life science organizations.

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Relevant translational animal models to advance disease research and drug development

Existing research models
5Ht3a-Cre Rat
AHR Knockout Rat
Alpha-Synuclein A53T SNCA Knock-in Rat
Alpha-Synuclein SNCA Knockout Rat
ApoE Knockout Rabbit
ApoE Knockout Rat
App Knockout Rat
Bcrp Knockout Rat
BDNF Knockout Rat
BSEP Knockout Rat
Cacna1c Knockout Rat
CamKIIa-Cre Rat
CAR Knockout Rat
CFTR Knockout Rat
Channelrhodopsin Rat
CHD8 Knockout Rat
Cntnap2 Knockout Rat
Chrna7 Knockout Rat
Cox1 Knockout Rat
Cox2 Knockout Rat
Disc1 Knockout Rat
Faah Knockout Rat
Fmr1 Knockout Rat
Gabrb3 Knockout Rat
Halorhodopsin Rat
hApoE4 Knock-In Rat
Ldlr Knockout Rat
Leptin Knockout Rat — KiloRat

Lgals1 (Gal1) Knockout Rat
Lrrk1 Knockout Rat
Lrrk1-Lrrk2 Knockout Rat
Lrrk2 Knockout Rat
Mdr1a - Bcrp Knockout Rat
Mdr1a Knockout Rat
Mdr1a/1b Knockout Rat
MeCP2 Knockout Rat
Met Knockout Rat
mGluR5 Knockout Rat
Mrp1 Knockout Rat
Mrp2 Knockout Rat
Neurexin1 - Nrxn1 Knockout Rat
Neuroligin 3 (Nlgn3) Knockout Rat
Oat1 Knockout Rat
Oat3 Knockout Rat
Oct1 Knockout Rat
Oct2 Knockout Rat
Oprm1 Knockout Rat
p53 Knockout Rat
p75NTR Knockout Rat
Park2 Parkin Knockout Rat
Park7 DJ-1 Knockout Rat
Parvalbumin-Cre Rat
Pde4b Knockout Rat
Pink1 Knockout Rat - Park6
Ppara Knockout Rat
Prkdc Knockout Rat
Pten Knockout Rat

PXR Knockout Rat
PXR/CAR Knockout Rat
PXR/CAR/AHR Knockout Rat
Rbfox1 Knockout Rat
Rag1 Knockout Rat (Fischer 344)
Rag1 Knockout Rat | Sprague-Dawley
Rag2 Knockout Rat (Fischer 344)
Rag2 Knockout Rat | Sprague-Dawley
Sst-Cre
Tbx21 (T-beta) Knockout Rat
tdTomato Reporter Rat
Tph2-Cre Rat
Trpv1 Knockout Rat
Tyrosine Hydroxylase TH-Cre Rat
Vgat-Cre Rat
VIP-Cre Rat

Inbred model application
Balb/c Mice, Inbred Mouse
C57Bl/6 Inbred Mouse

Outbred model application
Sprague-Dawley Outbred Rat

Get the most out of your animal models

  • Custom breeding and transgenic services
  • Reproductive services
  • Blood and tissue sampling
  • Molecular characterization
  • Phenotypic characterization

Oncology models to mirror cancer

  • Patient derived xenografts (PDX)
  • Cell derived xenografts (CDX)
  • Syngeneic
  • In vivo CRISPR screening

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