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Phytoestrogen references

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  • Appt SE, 2003.Usefulness of the monkey model to investigate the role of soy in postmenopausal women’s health. 
    ILAR 45:200-211.
  • Barnes S, Kim H. 2010. Cautions and research needs identified at the Equol, Soy and Menopause Research Conference.
    J Nutr 140:1390S-1394S.
  • Barnes S. 2004.  Soy Isoflavones-Phytoestrogens and what else?  
    J Nutr 134:1225S-1228S.
  • Branham WS, Dial, SL, Moland CL, Hass BS, Blair RM, Fang H, Shi L, Tong W, Perkins RG, Sheehan DM. 2002. Phytoestrogens and mycoestrogens bind to the rat uterine estrogen receptor.
    J Nutr 132:658-664.
  • Casanova M, You L, Gaido KW, Archibeque-Engle S, Janszen DB, Heck HA. 1999. Developmental effects of dietary phytoestrogens in Sprague-Dawley rats and interactions of genistein and daidzein with rat estrogen receptors alpha and beta in vitro.
    Toxicol Sc 51:236-244.
  • Cederroth CR, Nef S. 2009. Soy, phytoestrogens and metabolism: A review.
    Mol Cell Endocrinol 304:30-42.
  • Cooke PS, Naaz A. 2004. Role of estrogens in adipocyte development and function.
    Exp Biol Med (Maywood) 229:1127-1135.
  • Dia VP, Berhow MA, De Mejia EG. 2008. Bowman-Birk inhibitor and genestein among soy compounds that synergistically inhibit nitric oxide and prostaglandin E2 pathways in lipopolysaccharide-induced macrophages.
    J Agric Food Chem 56:11707-11717
  • Dixon RA. 2004. Phytoestrogens.
    Annu Rev Plant Biol 55:225-261.
  • Erdman Jr.  JW, Badger TM, Lampe JW, Setchell KDR, Messina M. 2004. Not all soy products are created equal: caution needed in interpretation of research results.
    J Nutr 134:1229S-1233S.
  • Fukutake, M., Takahashi, M., Ishida, K., Kawamura, H., Sugimura, T. & Wakabayashi, K. 1996. Quantification of genistein and genistin in soybeans and soybean products.
    Food Chem Toxicol 34:457-461.
  • Imamov O, Shim GJ, Warner M, Gustafsson JA. 2005. Estrogen receptor beta in health and disease.
    Biol Reprod 73:866-871.
  • Jefremov V, Zilmer M, Zilmer K, Bogdanovic N, Karelson E. 2007. Antioxidative effects of plant polyphenols.
    Ann NY Acad Sci 1095:449-457.
  • Jensen MN, Ritskes-Hoitinga M. 2007. How isoflavone levels in common rodent diets can interfere with the value of animal models and with experimental results.
    Lab Anim 41:1-18.
  • Kim, H., Peterson, T.G. & Barnes, S. 1998. Mechanisms of action of the soy isoflavone genistein: emerging role for its effects via transforming growth factor beta signaling pathways.
    Am J Clin Nutr 68:1418S-1425S.
  • Kinjo J, Tsuchihashi R, Morito K, Hirose T, Aomori T, Nagao T, Okabe H, Nohara T, Masamune Y. 2004. Interactions of phytoestrogens with receptors α and β (III).  Estrogenic activities of soy isoflavone aglycones and their metabolites isolated from human urine.
    Biol Pharm Bull 27:185-188.
  • Klump SP, Allred MC, MacDonald JL, Ballam JM. 2001. Determination of isoflavones in soy and selected foods containing soy by extraction, saponification, and liquid chromatography: collaborative study.
    J AOAC Int 84:1865-1883.
  • Makela SI, Pylkkanen LH, Santti RS, Adlercreutz H. 1995. Dietary soybean may be antiestrogenic in male mice.
    J Nutr 125:437-445.
  • Messina M. 2010. A brief historical overview of the past two decades of soy and isoflavone research.
    J Nutr140:1350S-1354S.
  • Messina M, Watanabe S, Setchell KD. 2009. Report on the 8th International Symposium on the Role of Soy in Health Promotion and Chronic Disease Prevention and Treatment.
    J Nutr139:796S-802S.
  • Moiseeva EP, Manson MM. 2009. Dietary chemopreventive phytochemicals:Too Little or Too Much?
    Cancer Prev Res 2:611-616.
  • Moutsatsou P. 2007. The spectrum of phytoestrogens in nature: our knowledge is expanding.
    Hormones 6:173-193.
  • Murphy PA, Song T, Buseman G, Barua K, Beecher GR, 1999.  Isoflavones in retail and institutional soy foods. 
    J Agr Food Chem 47:2697-2704.
  • Pastuszewska B, Taciak M, Ochtabinska A, Tusnio A, Misztal T, Romanowicz K, Morawski A. 2008.  Nutritional value and physiological effects of soya-free diets fed to rats during growth and reproduction.
    J Anim Physiol An N 92:63-74.
  • Rafii F, Hotchkiss C, Heinze TM, Park M. 2004. Metabolism of daidzein by intestinal bacteria from Rhesus monkeys.
    Comparative Med 54:165-169.
  • Spearow JL, Doemeny P, Sera R, Leffler R,  Barkley M. 1999. Genetic variation in susceptibility to endocrine disruption by estrogen in mice.
    Science 285:259-261.
  • Setchell KD. 1998. Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones.
    Am J Clin Nutr 68:1333S-1346S.
  • Thigpen JE, Setchell KD, Saunders HE, Haseman JK, Grant MG, Forsythe DB . 2004. Selecting the appropriate rodent diet for endocrine disruptor research and testing studies.
    ILAR J 45:401-416.
  • Whitten PL, Patisaul HB. 2001. Cross-species and interassay comparisons of phytoestrogen action.
    Environ Health Perspect 109 Suppl 1:5-20.
  • Anthony MS, Clarkson TB, Williams JK. 1998. Effects of soy isoflavones on atherosclerosis: potential mechanisms.
    Am J Clin Nutr 68:1390S-1393S.
  • Anthony MS, Clarkson TB, Hughes, Jr. CL, Morgan TM, Burke GL. 1996. Soybean isoflavones improve cardiovascular risk factors without affecting the reproductive system of peripubertal Rhesus monkeys.
    J Nutr 126:43-50.
  • Bian Z, Nilsson S, Gustafsson JA. 2001. Selective estrogen receptor modulators and coronary heart disease.
    Trends Cardiovasc Med11:196-202.
  • Blair RM, Appt SE, Bennetau-Pelissero C, Clarkson TB, Anthony MS, Lamothe V, Potter SM. 2002. Dietary soy and soy isoflavones have gender-specific effects on plasma lipids and isoflavones in golden Syrian f1b hybrid hamsters.
    J Nutr 132:3585-3591.
  • Carroll KK, Kurowska EM. 1995. Soy consumption and cholesterol reduction: review of animal and human studies.
    J Nutr 125:594S-597S.
  • Cho TM, Peng N, Clark JT, Novak L, Roysommuti S, Prasain J, Wyss JM. 2007. Genistein attenuates the hypertensive effects of dietary NaCl in hypertensive male rats.
    Endocrinology 148:5396-5402.
  • Clarkson TB. 2002. Soy, soy phytoestrogens and cardiovascular disease.
    J Nutr 132:566S-569S.
  • Douglas G, Armitage JA, Taylor PD, Lawson JR, Mann GE, Poston L. 2006. Cardiovascular consequences of life-long exposure to dietary isoflavones in the rat.
    J Physiol571:477-487.
  • Droke EA, Hager, KA, Lerner MR, Lightfoot SA, Stoecker BJ, Brackett DJ, Smith BJ. 2007. Soy isoflavones avert chronic inflammation-induced bone loss and vascular disease.
    Journal of Inflamm 4:17
  • Kaspers SK, Kok L, Bots ML, Grobbee DE, van der Schouw YT. 2005. Dietary phytoestrogens and plasma lipids in Dutch postmenopausal women; a cross sectional study.
    Atherosclerosis 178:95-100.
  • Lee CS, Kwon SJ, Na SY, Lim SP, Lee JH. 2004. Genistein supplementation inhibits atherosclerosis with stabilization of the lesions in hypercholesterolemic rabbits.
    J Korean Med Sci19:656-661.
  • Lichtenstein AH. 1998. Soy protein, isoflavones and cardiovascular disease risk.
    J Nutr  128:1589-1592.
  • Nagarajan S, Burris RL, Stewart BW, Wilkerson JE, Badger TM. 2008. Dietary soy protein isolate ameliorates atherosclerotic lesions in apolipoprotein E-deficient mice potentially by inhibiting monocyte chemoattractant protein-1 expression.
    J Nutr 138:332-337.
  • Potter SM, Pertile J, Berber-Jimenez MD. 1996.Soy protein concentrate and isolated soy protein similarly lower blood serum cholesterol but differently affect thyroid hormones in hamsters.
    J Nutr 126:2007-2011.
  • Rivas M, Garay RP, Escanero JF, Cia P, Jr., Cia P. 2002.  Soy milk lowers blood pressure in men and women with mild to moderate essential hypertension. 
    J Nutr 132:1900-1902.
  • Ronis MJ, Chen Y, Badeaux J, Badger TM. 2009. Dietary soy protein isolate attenuates metabolic syndrome in rats via effects on PPAR, LXR, and SREBP signaling.
    J Nutr139:1431-1438.
  • Souzeau E, Belanger S, Picard S, Deschepper C F. 2005. Dietary isoflavones during pregnancy and lactation provide cardioprotection to offspring rats in adulthood.
    Am J Physiol-Heart C 289:715-21.
  • Tovar AR, Murguia F, Cruz C, Hernandez-Pando R, Aguilar-Salinas CA, Pedraza-Chaverri, J, Correa-Rotter R, Torres N. 2002.  A soy protein diet alters hepatic lipid metabolism gene expression and reduces serum lipids and renal fibrogenic cytokines in rats with chronic nephrotic syndrome.
    J Nutr 132:2562-2569.
  • Anderson JJ, Garner SC. 1998. Phytoestrogens and bone.
    Baillieres Clin Endocrinol Metab 12: 543-557.
  • Arjmandi BH, Birnbaum R, Goyal NV, Getlinger MJ, Juma S, Alekel L, Hasler CM, Drum ML, Hollis BW, Kukreja SC. 1998. Bone-sparing effect of soy protein in ovarian hormone-deficient rats is related to its isoflavone content.
    Am J Clin Nutr 68:1364S-1368S.
  • Arjmandi BH, Alekel L, Hollis BW, Amin D, Stacewicz-Sapuntzakis M, Guo P, Kukreja SC. 1996. Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis.
    J Nutr126:161-167.
  • Coxam V. 2003. Prevention of osteopaenia by phyto-oestrogens: animal studies.
    Br J Nutr 89 Suppl 1:S75-85.
  • Droke EA, Hager, KA, Lerner MR, Lightfoot SA, Stoecker BJ, Brackett DJ, Smith BJ. 2007. Soy isoflavones avert chronic inflammation-induced bone loss and vascular disease.
    Journal of Inflamm 4:17
  • Fanti P, Monier-Faugere MC, Geng Z, Schmidt J, Morris PE, Cohen D, Malluche HH. 1998. The phytoestrogen genistein reduces bone loss in short-term ovariectomized rats.
    Osteoporos Int 8:274-281.
  • Ishimi Y. 2010. Dietary equol and bone metabolism in postmenopausal Japanese women and osteoporotic mice.
    J Nutr 140:1373S-1376S.
  • Ishimi Y, Yoshida M, Wakimoto S, Wu J, Chiba H, Wang X, Takeda K, Miyaura C. 2002. Genistein, a soybean isoflavone, affects bone marrow lymphopoiesis and prevents bone loss in castrated male mice.
    Bone 31:180-185.
  • Ishimi Y, Arai N, Wang X, Wu J, Umegaki K, Miyaura C, Takeda A, Ikegami S. 2000. Difference in effective dosage of genistein on bone and uterus in ovariectomized mice.
    Biochem Biophys Res Commu, 274:697-701.
  • Jefferson WN, Padilla-Banks E, Newbold RR. 2005. Adverse effects on female development and reproduction in CD-1 mice following neonatal exposure to the phytoestrogen genistein at environmentally relevant doses.
    Biol Reprod73:798-806.
  • Kaludjerovic J, Ward WE. 2009. Neonatal exposure to daidzein, genistein, or the combination modulates bone development in female CD-1 mice.
    J Nutr 139:467-473.
  • Khalil DA. 2002.  Soy protein supplementation increases serum insulin-like growth factor-I in young and old men but does not affect markers of bone metabolism. 
    J. Nutr132:2605-2608.
  • Lee YB, Lee HJ, Kim KS, Lee JY, Nam SY, Cheon SH, Sohn HS. 2004. Evaluation of the preventive effect of isoflavone extract on bone loss in ovariectomized rats.
    Biosci Biotechnol Biochem 68:1040-1045.
  • Ohta A, Uehara M, Sakai K, Takasaki M, Adlercreutz H, Morohashi T,  Ishimi Y. 2002. A combination of dietary fructooligosaccharides and isoflavone conjugates increases femoral bone mineral density and equol production in ovariectomized mice.
    J Nutr 132:2048-2054.
  • Picherit C, Horcajada MN, Mathey J, Chanteranne B, Puel C, Lebecque P, Davicco MJ, Coxam V, Barlet JP. 2003. Isoflavone consumption does not increase the bone mass in osteopenic obese female zucker rats.
    Ann Nutr Metab 47:70-77.
  • Picherit C, Chanteranne B, Bennetau-Pelissero, C, Davicco, MJ, Lebecque, P, Barlet JP, Coxam V. 2001. Dose-dependent bone-sparing effects of dietary isoflavones in the ovariectomised rat.
    Br J Nutr  85:307-316.
  • Picherit C, Coxam V, Bennetau-Pelissero C, Kati-Coulibaly S, Davicco MJ, Lebecque P, Barlet JP. 2000. Daidzein is more efficient than genistein in preventing ovariectomy-induced bone loss in rats.
    J Nutr130:1675-1681.
  • Setchell KD, Lydeking-Olsen E. 2003. Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies.
    Am J Clin Nutr 78: 593S-609S.
  • Adlercreutz H, Mazur W, Bartels P, Elomaa V-V, Watanabe S, Wahala K, Landstrom M, Lundin E, Bergh A, Damber J-E, Aman P, Widmark A, Johansson A, Zhang J-X, Hallmans G. 2000. Phytoestrogens and prostate disease.
    J. Nutr. 130:658S-659S.
  • Allred CD, Allred KF, Ju YH, Clausen LM, Doerge DR, Schantz SL, Korol DL, Wallig MA, Helferich WG. 2004. Dietary genistein results in larger MNU-induced, estrogen-dependent mammary tumors following ovariectomy of Sprague-Dawley rats.
    Carcinogenesis 25:211-218.
  • Allred CD, Allred KF, Ju YH, Goeppinger TS, Doerge DR, Helferich WG. 2004.  Soy processing influences growth of estrogen-dependent tumors.
    Carcinogenesis 25:1649-1657.
  • Allred CD, Allred KF, Ju YH, Virant SM, Helferich WG. 2001. Soy diets containing varying amounts of genistein stimulate growth of estrogen-dependent (MCF-7) tumors in a dose-dependent manner.
    Cancer Res 61:5045-5050.
  • Allred CD, Ju YH, Allred KF, Chang J,  Helferich WG. 2001. Dietary genistin stimulates growth of estrogen-dependent breast cancer tumors similar to that observed with genistein.
    Carcinogenesis 22:1667-1673.
  • Barnes S. 1995. Effect of genistein on in vitro and in vivo models of cancer.
    J Nutr 125: 777S-783S.
  • Bises G, Bajna E, Manhardt T, Gerdenitsch W, Kallay E, Cross HS. 2007. Gender-specific modulation of markers for premalignancy by nutritional soy and calcium in mouse colon.
    J Nutr 137:211S-215S.
  • Chau MN, El Touny LH, Jagadeesh S, Banerjee PP. 2007. Physiologically achievable concentrations of genistein enhance telomerase activity in prostate cancer cells via the activation of STAT3.
    Carcinogenesis 28:2282-2290.
  • Chen J, Saggar JK, Corey P, Thompson LU. 2009. Flaxseed and pure secoisolariciresinol diglucoside, but not flaxseed hull, reduce human breast cancer growth (MCF-7) in athymic mice.
    J Nutr 139:2061-2066.
  • Chiesa G, Rigamonti E, Lovati MR, Disconzi E, Soldati S, Sacco MG, Cato EM, Patton V, Scanziani E, Vezzoni P, Arnoldi A, Locati D, Sirtori CR. 2008. Reduced mammary tumor progression in a transgenic mouse model fed an isoflavone-poor soy protein concentrate.
    Mol Nutr Food Res52:1121-1129.
  • Cho NL, Javid SH, Carothers AM, Redston M, Bertagnolli MM. 2007. Estrogen receptors α and β are inhibitory modifiers of Apc-dependent tumorigenesis in the proximal colon of Min/+ mice.
    Cancer Res 67:2366-2372.
  • Cross HS, Kallay E, Lechner D, Gerdenitsch W, Adlercreutz H, Armbrecht HJ. 2004. Phytoestrogens and vitamin D metabolism: A new concept for the prevention and therapy of colorectal, prostate, and mammary carcinomas.
    J Nutr 134:1207S-1212S.
  • Day JK, Bauer AM, DesBordes C, Zhuang Y, Kim BE, Newton LG, Nehra V, Forsee KM, MacDonald RS, Besch-Williford C, Huang TH, Lubahn DB. 2002. Genistein alters methylation patterns in mice.
    J Nutr132:2419S-2423S.
  • Diel P, Smolnikar K, Schulz T, Laudenbach-Leschowski U, Michna H,  Vollmer G. 2001.Phytoestrogens and carcinogenesis-differential effects of genistein in experimental models of normal and malignant rat endometrium.
    Hum Reprod 16:997-1006.
  • Dijsselbloem N, Berghe WV, Naeyer AD, Haegeman G. 2004. Soy isoflavone phyto-pharmaceuticals in interleukin-6 affections: Multi-purpose nutraceuticals at the crossroad of hormone replacement, anti-cancer and anti-inflammatory therapy.
    Biochem Pharmacol 68:1171-1185.
  • Gallo D, Zannoni GF, Stefano ID, Mosca M, Ferlina C, Mantuano E, Scambia Giovanni. 2008. Soy phytochemicals decrease nonsmall cell lung cancer growth in female athymic mice.
    J Nutr 138:1360-1364.
  • Gilad LA, Tirosh O, Schwartz B. 2006. Phytoestrogens regulate transcription and translation of vitamin D receptor in colon cancer cells.
    J Endocrinol 191: 387-398 .
  • Guo TL, Chi RP, Hernandez DM, Auttachoat W, Zheng JF. 2007. Decreased 7,12-dimethylbenz[a]anthracene-induced carcinogenesis coincides with the induction of antitumor immunities in adult female B6C3F1 mice pretreated with genistein.
    Carcinogenesis 28:2560-2566.
  • Guo JM, Kang GZ, Xiao BX, Liu DH, Zhang S. 2004. Effect of daidzein on cell growth, cell cycle, and telomerase activity of human cervical cancer in vitro. 
    Int J Gynecol Cancer 14:882-888.
  • Guo JM, Xiao BX, Liu DH, Grant M, Zhang S, Lai YF, Guo YB, Liu Q. 2004. Biphasic effect of daidzein on cell growth of human colon cancer cells.
    Food Chem Toxicol 42:1641-1646.
  • Guo JY, Li X, Browning JD, Jr., Rottinghaus GE, Lubahn DB, Constantinou A, Bennink M,  MacDonald RS. 2004. Dietary soy isoflavones and estrone protect ovariectomized ERalphaKO and wild-type mice from carcinogen-induced colon cancer.
    J Nutr 134:179-182.
  • Guo TL, McCay JA, Zhang LX, Brown RD, You L, Karrow NA, Germolec DR, Jr., White KL, 2001. Genistein modulates immune responses and increases host resistance to B16F10 tumor in adult female B6C3F1 mice.
    J Nutr 131: 3251-3258.
  • Handayani R, Rice L, Cui Y, Mendrano TA, Samedi VG, Baker HV, Szabo NJ, Shiverick KT. 2006. Soy isoflavones alter expression of genes associated with cancer progression, including interleukin-8, in androgen-independent PC-3 human prostate cancer cells.
    J Nutr 136:75-82.
  • Hawrylewicz EJ, Zapata JJ, Blair WH. 1995. Soy and experimental cancer: animal studies.
    J Nutr 125:698S-708S.
  • Hilakivi-Clarke L, Cho E, deAssis S, Olivo S, Ealley E, Bouker KB, Welch JN, Khan G, Clarke R, Cabanes A. 2001. Maternal and prepubertal diet, mammary development and breast cancer risk.
    J Nutr131:154S-157S.
  • Hsieh CY, Santell RC, Haslam SZ, Helferich WG. 1998. Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo.
    Cancer Res58:3833-3838.
  • Imamura F, Shinkai K, Mukai M, Yoshioka, K, Komagome R, Iwasaki T,  Akedo H. 1996. rho-Mediated protein tyrosine phosphorylation in lysophosphatidic-acid-induced tumor-cell invasion.
    Int J Cancer 65:627-632.
  • Javid SH, Moran AE, Carothers AM, Redston M, Bertagnolli MN. 2005. Modulation of tumor formation and intestinal cell migration by estrogens in the ApcMin/+ mouse model of colorectal cancer.
    Carcinogenesis 26:587-595.
  • Jeng Y, Kochukov M, Nauduri D, Kaphalia B, Watson CS. 2010. Subchronic exposure to phytoestrogens alone and in combination with diethylstilbestrol-pituitary tumor induction in Fischer 344 rats.
    Nutrition and Metabolism 7:40-53
  • Jiang X, Patterson NM, Ling Y, Xie J, Helferich WG, Shapiro DJ. 2008. Low concentrations of the soy phytoestrogen genistein induce proteinase inhibitor 9 and block killing of breast cancer cells by immune cells.
    Endocrinology 149:5366-5373.
  • Ju YH, Doerge DR, Woodling KA, Hartman JA, Kwak J, Helferich WG . 2008. Dietary genistein negates the inhibitory effect of letrozole on the growth of aromatase-expressing estrogen-dependent human breast cancer cells (MCF-7Ca) in vivo.
    Carcinogenesis 29:2162-2168.
  • Ju YH, Fultz J, Allred KF, Doerge DR, Helferich WG. 2006. Effects of dietary daidzein and its metabolite, equol, at physiological concentrations on the growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in ovariectomized athymic mice.
    Carcinogenesis 27:856-863.
  • Ju YH, Doerge DR, Allred KF, Allred CD, Helferich WG. 2002. Dietary genistein negates the inhibitory effect of tamoxifen on growth of estrogen-dependent human breast cancer (MCF-7) cells implanted in athymic mice.
    Cancer Res 62:2474-2477.
  • Ju YH, Allred CD, Allred KF, Karko KL, Doerge DR, Helferich WG, 2001. Physiological concentrations of dietary genistein dose-dependently stimulate growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in athymic nude mice.
    J Nutr 131:2957-2962.
  • Kijkuokool P, Parhar IS, Malaivijitnond S. 2006. Genistein enhances N-nitrosomethylurea-induced rat mammary tumorigenesis.
    Cancer Lett 242:53-59.
  • Kim HA, Jeong KS, Kim YK. 2008. Soy extract is more potent than genistein on tumor growth inhibition.
    Anticancer Res 28:2837-2842.
  • Lamartiniere CA, Cotroneo MS, Fritz WA, Wang J, Mentor-Marcel R, Elgavish A . 2002. Genistein chemoprevention: timing and mechanisms of action in murine mammary and prostate.
    J Nutr132:552S-558S.
  • Lamartiniere CA, Moore JB, Brown NM, Thompson R, Hardin MJ, Barnes S. 1995. Genistein suppresses mammary cancer in rats.
    Carcinogenesis 16:2833-2840.
  • Lampe JW. 2010. Emerging research on equol and cancer.
    J Nutr 140:1369S-1372S.
  • Li D, Yee JA, McGuire MH, Murphy PA,  Yan L. 1999. Soybean isoflavones reduce experimental metastasis in mice.
    J Nutr  129:1075-1078.
  • Liu B, Edgerton S, Xiaohe Y, Kim A, Ordonez-Ercan D, Mason T, Alvarez K, McKimmey C, Naxin L, and Thor A. 2005.  Low-dose dietary phytoestrogen abrogates tamoxifen-associated mammary tumor prevention.
    Cancer Research 65:879-886.
  • Lund TD, Munson DJ, Adlercreutz H, Handa RJ, Lephart ED. 2004. Androgen receptor expression in the rat prostate is down-regulated by dietary phytoestrogens.
    Reprod Biol Endocrin 2:5
  • MacDonald RS, Guo J, Copeland J, Browning JD, Jr., Sleper D, Rottinghaus GE, Berhow MA. 2005. Environmental influences on isoflavones and saponins in soybeans and their role in colon cancer.
    J Nutr135:1239-1242.
  • Magee PJ,  Rowland IR. 2004.  Phyto-oestrogens, their mechanism of action: current evidence for a role in breast and prostate cancer.
    Brit J Nutr 91:513-531.
  • Mai Z, Blackburn GL, Zhou JR. 2007. Soy phytochemicals synergistically enhance the preventative effect of tamoxifen on the growth of estrogen-dependent human carcinoma in mice.
    Carcinogenesis 28:1217-1223.
  • Manjanatha MG, Shelton S, Bishop ME, Lyn-Cook LE, Aidoo A. 2006. Dietary effects of soy isoflavones daidzein and genistein on 7,12-dimethylbenz[a]anthracene-induced mammary mutagenesis and carcinogenesis in ovariectomized BIG BLUE® transgenic rats.
    Carcinogenesis 27:2555-2564.
  • Martinez-Montemayor MM, Otero-Franqui E. 2010. Individual and combined soy isoflavones exert differential effects on metastatic cancer progression.
    Clin Exp Metastasis 27:465-480.
  • Menon LG, Kuttan R, Nair MG, Chang YC Kuttan G.  1998. Effect of isoflavone genistein and daidzein in the inhibition of lung metastasis in mice induced by B16F-10 melanoma cells. 
    Nutr Cancer 30:74-77.
  • Mentor-Marcel R, Lamartiniere CA, Eltoum IE, Greenberg NM, Elgavish A. 2001. Genistein in the diet reduces the incidence of poorly differentiated prostatic adenocarcinoma in transgenic mice (TRAMP).
    Cancer Res61:6777-6782.
  • Messina MJ, Wood CE. 2008. Soy isoflavones, estrogen therapy, and breast cancer risk: analysis and commentary.
    Nutr J 7:17.
  • Moiseeva EP, Manson MM. 2009. Dietary chemopreventive phytochemicals:Too Little or Too Much?
    Cancer Prev Res 2:611-616.
  • Pugazhendhi D, Watson KA, Mills S, Botting N, Pope GS, Darbre PD. 2008. Effect of sulphation on the oestrogen agonist activity of the phytoestrogens genistein and daidzein in MCF-7 human breast cancer cells.
    Endocrinology 197:503-515.
  • Raju J, Bielecki A, Caldwell D, Lok E, Taylor M, Kapal K, Curran I, Cooke GM, Bird RP, Mehta R. 2008. Soy isoflavones modulate azoxymethane-induced rat colon carcinogenesis exposed pre- and postnatally and inhibit growth of DLD-1 human adenocarcinoma cells by increasing the expression of estrogen receptor-β1-3.
    J Nutr 139:474-481.
  • Rohrdanz E, Ohler S, Tran-Thi, QH, Kahl R. 2002. The phytoestrogen daidzein affects the antioxidant enzyme system of rat hepatoma H4IIE cells.
    J Nutr 132: 370-375.
  • Santell RC, Kieu N, Helferich WG. 2000. Genistein inhibits growth of estrogen-independent human breast cancer cells in culture but not in athymic mice.
    J Nutr 130:1665-1669.
  • Thiagarajan DG, Bennink MR, Bourquin LD, Kavas FA. 1998. Prevention of precancerous colonic lesions in rats by soy flakes, soy flour, genistein, and calcium.
    Am J Clin Nutr 68:1394S-1399S.
  • Thigpen JE, Locklear J, Haseman JK, Saunders H, Grant MF, Forsythe DB. 2001. Effects of the dietary phytoestrogens daidzein and genistein on the incidence of vulvar carcinomas in 129/J mice.
    Cancer Detect Prev 25:527-532.
  • Touny LHE, Banerjee PP. 2009. Identification of a biphasic role for genistein in the regulation of prostate cancer growth and metastasis.
    Cancer Res 69:3695-3703.
  • Verdeal K, Brown RR, Richardson T, Ryan DS. 1980. Affinity of phytoestrogens for estradiol-binding proteins and effect of coumestrol on growth of 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors.
    J Natl Cancer Inst 64:285-290.
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[Case study] Metabolic model