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Customer supplied ingredients

When your experiments require the addition or application of certain compounds to your animal research subject, you can consider adding your medications or compounds to your animal’s diet. Envigo has experience customizing diets for all types of research needs, and that includes introducing additives as a convenient way to medicate lab animals. Simply turn to one of our expert staff nutritionists to determine whether it is a viable option.

Medications or compounds supplied by your investigator are referred to as “customer supplied ingredients” or “customer reserves,” and they can be added to most diets. Generally, if the stability or activity of the compound is not compromised during manufacture or further processing such as irradiation, adding an ingredient can be a smart option for simplifying your feeding and medicating schedules. Also, the inclusion rate of any given compound is adjusted to suit your needs, and can be determined in consultation with our expert nutritional staff.

Some common customer supplied compounds include:

  • Cuprizone (also now stocked)
  • Tamoxifen (also now stocked - US, EU)
  • Purified fatty acids (DHA, EPA)
  • Curcumin
  • Rosiglitazone
  • Statins
  • Antibiotics
  • Valproate
  • Piroxicam
  • Berry powders
  • Bisphenol A (BPA, in diluted form)

When adding a compound to a diet, we will work with you to be sure that it is appropriate for our diet formulation procedures and can be done safely.

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  • We require a safety data sheet or other relevant safety and usage information
  • We have an obligation to maintain a safe work environment. This typically applies to drugs, experimental compounds and chemicals
  • Food products generally will not require safety information, although information about nutrient content, reason for use, etc. is helpful in the design of diets
  • Water is added as a pelleting aid. Pellets are formed under pressure but no external heat is applied
  • Sometimes the drying process can be modified if heat stability is questioned
  • It is your responsibility to determine the suitability of the compound for inclusion into a pelleted diet
  • If you require irradiation, we can customize most diets to be suitable for this sterilization process
  • Once your diet has been produced, we can send it for irradiation. The dose ranges from 20-50 kGy. Diets that are to be irradiated require an additional two weeks for shipment (four weeks total)
  • For diets that are to be irradiated, vacuum packaging may be beneficial. Both irradiation and vacuum packaging must be requested when ordering
  • We defer to you to determine the suitability of the compound for irradiation
  • Inform us on a g/kg diet or percentage basis, how much of the compound you want in the diet
  • If you need to calculate a dose based on animal body weight, we can help convert that to g/kg diet
  • Depending on the choice of base diet and the nature of the added ingredient(s), more than a ten percent dilution is generally not advisable
  • To limit differences between the control and experimental diets you may want to consider using a control diet that uses similar ingredients and has gone through the same production process
  • Send extra compound (approximately enough for one more kg than you have ordered) so that we can yield the desired amount of diet
  • If we have not received enough compound, we will use the entire amount and make as much diet as possible, unless special arrangements can be made
  • If you plan to use the compound more than once and stability with storage is not an issue, we can maintain an inventory for you and store it appropriately, per your instructions
  • Unless otherwise instructed, we will return any remaining compound with your shipment, but we do not dispose of the compound
  • If you would like your compound retained for future use, please supply us with a retention document

[Case study] Metabolic model