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Rodent models for oncology research

Envigo provides a breadth of quality oncology rodent models to customers around the world. Regardless of your location, you can explore our extensive and current database of peer-reviewed publications across major cancer cell lines to help you identify the right model for your tissue of interest and cell line. Click here to use Envigo’s new cell line reference tool.

Do you need more information? Download our brochure on Envigo’s rodent models for oncology below or contact us to get a quick and personal response from a customer service representative.

 

Oncology portfolio (US)

Confidence in selecting your immunodeficient rodent models

You can trust that Envigo’s broad rodent model portfolio will give you the precision and flexibility to achieve the potential of your research program. Envigo offers an extensive line of nude mice, SCID mice, and nude rats. We have decades of history behind our immunodeficient rodent models so you can be confident that they have proven performance in tumor uptake and growth.

Each rodent model has been characterized in the comparative table below to help your select the most appropriate model.

Expand All Tabs
Model Nomenclature Hair T Cells B Cells NK Cells
Nude mice
Athymic nude Hsd:Athymic Nude-Foxn1nu No Nonfunctional Functional Functional
BALB/c nude (EU) BALB/cOlaHsd-Foxn1nu No Nonfunctional Functional Functional
NMRI nude (EU) HsdCpb:NMRI-Foxn1nu No Nonfunctional Functional Functional
SCID mice
C.B-17 SCID C.B-17/IcrHsd-Prkdcscid Yes Nonfunctional Nonfunctional Functional
C.B-17 SCID (EU) C.B-17/IcrHan®Hsd-Prkdcscid Yes Nonfunctional Nonfunctional Functional
SCID/beige C.B-17/IcrHsd-PrkdcscidLystbg-J Yes Nonfunctional Nonfunctional Impaired
NOD.SCID NOD.CB17-Prkdcscid/NCrHsd Yes Nonfunctional Nonfunctional Impaired
SHrN® (EU) NOD.Cg-PrkdcscidHrhr/NCrHsd No Nonfunctional Nonfunctional Impaired
Rag mouse
R2G2TM B6;129-Rag2tm1FwaII2rgtm1Rsky
/DwlHsd
Yes Non-functional Non-functional Non-functional
Nude rat
Athymic nude Hsd:RH-Foxn1rnu No Nonfunctional Functional Functional

Model Immune Characteristics
  T Cells B Cells NK Cells APC cells, complement Additional notes on immuno-phenotype SCID Leakiness
SHrN®* Non-
functional
Non-
functional
Impaired function Differentiation and functional defects in APCs; absence of circulating complement   Very low
References: Characterization in Progress
NOD.SCID Non-
functional
Non-
functional
Impaired function Differentiation and functional defects in APCs; absence of circulating complement Radiosensitive (<400Gy); high incidence of lymphoma Low
References: Shultz, L.D. et al. (1995). J Immunol, 154:180-91.

Prochazka et al. (1992). Proc Natl Acad SciU.S.A., 89:3290-4.

Greiner, D.L. and Shultz, L.D. (1998). The use of NOD/LtSz-scid/scid mice in biomedical research. In: NOD Mice and Related Strains: Research Applications in Diabetes, AIDS, Cancer andOther Diseases. (Leiter E and Atkinson M, eds). Austin: RG Landes Company, pp 173-203.
SCID-beige Non-
functional
Non-
functional
Impaired function Functional deficits Lytic activity of NK cells impaired without reduced cell population or cytokine production Low
References: Mosier, D.E. et al. (1993). J Exp Med, 177:191-4.

Thomsen, M. et al. (2008). Toxicol, 246:18-23.
SCID Non-
functional
Non-
functional
Functional Normal Leaky phenotype dependent on genetic background; Radiosensitive (<400Gy) High (BALB/c); Moderate (C3H, ICR)
References: Bosma et al. (1983). Nature, 301:527-30.

Gibson, D.M. et al. (1989). Limited clonal diversity of serum immunoglobulin in leaky scid mice, pp 125-36. In: Current topics in microbiology and immunology: The scid mouse (Eds.): Bosma, M.J., Phillips, R.A., and; Schuler, M.). New York: Springer-Verlag,

Bosma, G. et al. (1988). J Exp Med,167:1016-33.

Poole, T.W. (1996). Lab Animal, 25:29-32.

Nonoyama, S. et al. (1993).J. Immunol., 150(9):3817-24.

Bosma, M.J. (1992). Immunodeficiency Reviews, 3:261-76.
Beige-nude-XID* Non-
functional
Impaired function Impaired function Partially defective Reduction in LAK activity; defect in lysosomal trafficking; Radiosensitive (<400Gy) N/A
References: Jicha (1992). J Immunother, 11:19-29.

Waggie, K.S. et al. (1992). Lab Anim Sci, 42:375-7.
Nude mouse* Non-
functional
Functional Functional Normal function T cell precursors unaffected by mutation; some extrathymic functional T cells with age N/A
References: Flanagan, S.P. (1966). Genet Res, 8:295-309.

Teicher, B.A. (Ed.). (2002). Tumor models in cancer research. Totowa, New Jersey: Humana Press Inc.

Croy, B.A. et al. (2001). Comp Med, 51(4):300-13.

Gullino, P.M. et al. (1976). Inst Lab Animal Resources News, 19:5-19.

Fogh, J. and Giovanella, B. (Eds.). (1978). The Nude Mouse in Experimental and Clinical Research. New York: Academic Press.
Nude rat* Non-
functional
Functional Functional Normal function   N/A
References: National Research Council. (Eds.). (1989). Immunodeficient Rodents: A Guide to Their Immunobiology, Husbandry, and Use. Washington, D.C.: National Academy Press.

Vos, J.G. et al. (1980). Clin immunol and Immunopathol, 15:229-37.

Schuurman, H. et al. (1992). ILAR, 34:1-12.

Taubman, M.A. et al.(1983). Immunol,49: 295-300.
*Hairless/nude-animal does not produce full pelage.
All models highly susceptible to opportunistic viral and bacterial infection.


Immunocompetent rodent models

Perhaps your project requires spontaneous and inducible tumor models. In addition to our extensive library of traditional rodent models, Envigo can provide you with a full line of spontaneous and inducible tumor models, as shown below.

Expand All Tabs
Model Nomenclature Research use
Mice
A/J A/JOlaHsd Spontaneous lung tumors
B6D2F1 B6D2F1/Hsd
B6D2F1/JRccHsd
B6D2F1/OlaHsd
Chemical induction of bladder tumors
C3H C3H/HeNHsd Spontaneous hepatocellular and mammary tumors
CBA CBA/CaOlaHsd
CBA/JCrHsd
Susceptible to chemical induction of myeloid leukemia; hepatoma in males; mammary tumors in females
C57BL/6 C57BL/6JOlaHsd
C57BL/6JRccHsd
C57BL/6NHsd
Accepts murine B16F10 melanoma grafts
SJL SJL/JCrHsd High incidence of reticulum cell sarcoma (comparable to Hodgkin’s), leukemia
Rats
ACI (NA) ACI/SegHsd Spontaneous testicular and prostate cancer in aged males; females highly susceptible to estrogen-induced mammary tumors; spontaneous pituitary tumors in both sexes
Brown norway BN/RijHsd Spontaneous bladder tumors; susceptible to chemical induction of myeloid leukemia
Wistar furth (NA) WF/NHsd High incidence of spontaneous leukemia and pituitary tumors
Model Nomenclature Research use
Mice
BALB/c BALB/cAnNHsd
BALB/cOlaHsd
Mammary tumors in aged mice; capable of monoclonal antibody production with injection of pristane and hybridoma cell line
Rats
Sprague Dawley® Hsd:Sprague Dawley® SD® Chemical tumor induction; carcinogenicity, toxicology; spontaneous tumors
Fisher 344 (NA) F344/NHsd Various spontaneous tumors in aged rats; carcinogenicity

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