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In-vitro Metabolism

To ensure the relevance of animal toxicological results, it is important to ensure that animals used in safety assessment are exposed to the same major metabolites as humans are.

In vitro studies are ideal for investigating drug metabolism pathways quickly. Envigo DMPK scientists are highly experienced at conducting and interpreting comparative metabolism studies supported by a dedicated metabolite identification team to help assess potential MIST issues (human-specific metabolites) early.

  • Comparative metabolism: metabolite profiling and identification using recombinant enzymes, liver microsomes and hepatocytes (including human)
  • Expert HPLC analyses with on-line or off-line radio-detection
  • Metabolite generation using in vitro systems

Avista and Envigo press release

The future of inhaled medications and inhalation technology

[Webinar] De-risking drug development: in vitro strategies that add value to your molecule